Huizhong Tan

Research/Areas of Interest

Astrocytes are one of the most prevalent cell types in the central nervous system (CNS) and are a key type of glial cell. They play an essential role for protecting neurons and maintaining nervous system homeostasis. Overactivation of astrocytes is closely related to neuroinflammation, while these cells are important for neurotransmitter clearance, as well as the regulation of cognitive and motor functions. Studying astrocytes in neurodegenerative diseases helps to reveal the mechanisms behind these conditions.

CD63 is a membrane protein present in many cell types, involved in forming and transporting endosomes, and serves as a marker for exosomes. It plays a role in how cells communicate and exchange materials. In some neurodegenerative diseases, CD63 might contribute to the disease process.

My thesis project is still in the early stages. We aim to explore how CD63 affects the endosomal system in astrocytes and how it influences exosome secretion. I have noticed notable differences between the control and experimental groups so far. Our ongoing research hopes to shed light on CD63’s role in neurodegenerative diseases and offer new perspectives for treatment and intervention.