Rachel Covitz

Receptor Interacting Protein Kinases (RIPKs) are a family of kinases involved in a variety of signaling cascades involved in inflammatory response and cell death. Necroptosis is a regulated form of necrotic cell death mediated by RIPK1/3 activation that has been implicated in ischemic injury, autoimmune, and neurodegenerative disease. My research centers on studying the necroptotic pathway, with specific focus on understanding the molecular mechanisms behind altered cellular response to necroptotic stimulation. Additionally, I am collaborating on projects studying the role of RIPK2 in inflammatory disease and understanding how catalytic-dependent and independent activity affects drug response and pathway induction.