Research/Areas of Interest: We use the power of genetic engineering with high resolution microscopy to untangle the brain's neural circuitry. Our work is focused on how such wiring supports the flexible use of behaviors, and how these wiring patterns relate to susceptibility or resilience in genetic models of neurodegenerative diseases. We test our hypotheses using a variety of experimental approaches including array tomography, electron microscopy, rabies circuit tracing, calcium imaging, and chemogenetic perturbations in awake, behaving mice.