Sherrea Brown

Congenital anomalies, also commonly known as birth defects, are structural or functional anomalies that occur during fetal development. Mouse models are frequently used to study the underlying genetic causes of congenital anomalies and studies into these disorders often involve the use of transgenic mouse lines. While transgenic mice are effective and prove useful in studying various congenital anomalies, they can sometimes take long periods of time to be developed. My work aims to utilize CRISPR technology to generate embryonic mouse models of congenital anomalies quickly and efficiently. In doing so, we hope to be able to generate more precise genetic mutations that model the mutations associated with various congenital anomalies in a more time efficient manner.