Naga Pradeep Rayana

My research aims to elucidate the pathogenic mechanisms underlying monogenic retinal diseases with a focus on pathways that impact the homeostasis of retina and its supporting retinal pigment epithelium and glial cell. Initially, I will examine the genetic and molecular changes underlying the disease pathology in Mfrp^rd6, Prss56^glcr4 and Adipor1^-/- mouse models. The disrupted genes found in these models have been shown to genetically interact and homologs of each all are known to cause human retinal diseases.