Miaofen Hu

Research/Areas of Interest

My laboratory studies the role of cyclin dependent kinase 6 (CDK6) in development and cancer, with the aim of determining and identifying the novel therapeutic target genes regulated by CDK6 in these processes. CDK6, a cell cycle regulator, is predominantly expressed in hematopoietic cells and adipocytes and overexpressed or activated in human cancers such as T cell acute lymphoblastic leukemia (T-ALL), breast cancer, lung cancer, and obesity. We use mouse models with targeted mutations in Cdk6 in our studies.