Ewelina Bolcun-Filas

Research/Areas of Interest

Germ cells are unique in that they must withstand extensive DNA damage in the form of programmed meiotic double-strand breaks (DSBs) during their normal development. Paradoxically, the absence of DSBs during meiosis, as well as persistent unrepaired breaks, can be detrimental and often result in meiotic arrest and infertility. Our research focuses on unraveling the molecular mechanisms that control the development of healthy gametes and understanding how misregulation of these mechanisms can lead to reproductive disorders. Additionally, we investigate how chemotherapy and radiation-induced damage impact immature eggs, increasing the risk of premature ovarian failure and infertility in female cancer survivors. Our ultimate goal is to develop treatments that protect ovaries and prevent reproductive problems in female cancer patients.