Charlotte Kuperwasser, Ph.D.

Our lab focuses on exploring molecular mechanisms, cellular interactions, and microenvironmental influences in breast development and cancer. We develop advanced organoid technologies for detailed studies of organogenesis and stromal interactions and investigate regulatory networks and epigenetic mechanisms affecting cell lineage and plasticity, particularly under the influence of transcription factors and BRCA1 mutations. Our research also delves into the breast microenvironment, examining how cellular and extracellular components, including fibroblasts and adipose stromal cells, contribute to cancer development through effects on collagen deposition, cytokine release, and lipid metabolism and hormones. This comprehensive approach offers new insights into breast tissue regeneration, cancer progression, and potential therapeutic targets.