Iris Jaffe

Research/Areas of Interest

Dr. Jaffe's research combines her background in molecular and vascular biology with her interest as a clinical Cardiologist to explore molecular mechanisms that contribute to common cardiovascular diseases with a goal of identifying novel treatments. Her lab has specifically focused on the role of the aldosterone-responsive mineralocorticoid receptor (MR) in blood vessels and demonstrated a direct contribution to hypertension, atherosclerosis, vascular remodeling, vein graft failure, and vascular aging with an emphasis on understanding sex differences. More recently, part of her lab is also focused on cardiooncology.

Her group focuses on molecular mechanisms of vascular disease including:
1. The role of the steroid hormone aldosterone and the mineralocorticoid receptor in hypertension, vascular injury, and atherosclerosis.
2. Molecular mechanisms of steroid-regulated gene expression in the vasculature.
3. Mechanisms for sex differences in cardiovascular disease.
4. Mechanisms of cardiovascular aging.
5. Mechanisms of post-preeclampsia cardiovascular disease
6. Vascular complications of targeted cancer therapies