Research/Areas of Interest
The anatomy and physiology of thyrotropin-releasing hormone (TRH) synthesizing neurons in the hypothalamic paraventricular nucleus (PVN): 1) the choroid plexis and cerebral spinal fluid in the transport of T4 into the brain; 2) type 2 deiodinase in ependymal cells (tanycytes) on feedback inhibition of thyroid hormone on hypophysiotropic TRH neurons in the PVN; 3) leptin-mediated paradoxic reduction in the biosynthesis of TRH in the PVN during fasting; and 4) the anatomical characterization, nuclear/cytoplasmic distribution, and potential interaction of thyroid hormone receptors in thyroid hormone responsive and unresponsive TRH neurons in the brain and their response to hormonal manipulation.
Education
- PhD, Tufts University, United States, 1984
- MD, University of Vermont, United States, 1976
- BA, Brandeis University, United States, 1972