Daniel Jay, Ph.D.

I remain active in teaching but no longer accept thesis students.

My laboratory developed Chromophore-Assisted Laser Inactivation (CALI) to inactivate specific proteins in living cells at precise times and location. We used CALI with antibody libraries in a high throughput and automated fashion to discover new proteins that act in cancer cell invasiveness identified an extracellular form of Heat Shock Protein 90 (Hsp90) that acts to activate pro-invasive proteins in the tumor microenvironment to increase invasion, the first step in metastasis. We studied how this activation occurs and whether inhibition of extracellular Hsp90 could be a novel treatment to reduce metastasis of breast cancer.