Beverly Rubin

Research/Areas of Interest

Gonadotropin releasing hormone (GnRH) is the primary hypothalamic signal regulating pituitary gonadotropin secretion, and as such it is essential for reproductive fertility. Patterns of GnRH release are sexually dimorphic, established perinatally, and altered with age. We are interested in further deciphering the exquisitely orchestrated events involved in the regulation of GnRH secretion required to support reproductive cyclicity and ovulation in female mammals and in delineating age-related changes that contribute to reproductive decline. We are also examining how the development, function, and aging of the reproductive axis are influenced by early exposure to endocrine disruptors and studying how perinatal exposure to endocrine disruptors can exert long term effects on body weight regulation.