Mammalian Genetics at JAX Student Publications

Publication in peer-reviewed journals is a very important part of graduate training. Publications by students in the Mammalian Genetics at JAX track in the past five years are listed below. Note that the track admitted its first students in 2011. The names of student authors are in bold font.

2024

Hartig EI, Day M, Jarysta A, Tarchini B. 2024. Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life. Proc Natl Acad Sci USA Oct;121(40):e2405455121. doi: 10.1073/pnas.2405455121. Abstract

Heuer SE, Bloss EB, Howell GR.. 2024. Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease. Neuropharmacology. May 3:109987. doi: 10.1016/j.neuropharm.2024.109987. Abstract

Diemler CA, MacLean M, Heuer SE, Hewes AA, Marola OJ, Libby RT, Howell GR. 2024. Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma. Front Aging Neurosci. Jul 2;16:1396443. doi: 10.3389/fnagi.2024.1396443. Abstract

O'Connor C, Keele GR, Martin W, Stodola T, Gatti D, Hoffman BR, Korstanje R, Churchill GA, Reinholdt LG. 2024. Unraveling the genetics of arsenic toxicity with cellular morphology QTL. PLoS Genet. Apr 25;20(4):e1011248. doi: 10.1371/journal.pgen.1011248. Abstract

Wells AE, Wilson JJ, Heuer SE, Sears JD, Wei J, Pandey R, Costa MW, Kaczorowski CC, Roopenian DC, Chang CH, Carter GW. 2024. Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice. PLoS One. Mar 7;19(3):e0299595. doi: 10.1371/journal.pone.0299595. Abstract

2023

Arora UP, Sullivan BA, Dumont BL. 2023. Variation in the CENP-A sequence association landscape across diverse inbred mouse strains.Cell Rep. Sep 23;42(10):113178. doi: 10.1016/j.celrep.2023.113178. Abstract

Gambogi CW, Pandey N, Dawicki-McKenna JM, Arora UP, Liskovykh MA, Ma J, Lamelza P, Larionov V, Lampson MA, Logsdon GA, Dumont BL, Black BE. 2023. Centromere innovations within a mouse species. Sci Adv. Nov 17;9(46):eadi5764. doi: 10.1126/sciadv.adi5764. Abstract

Garretson A, Dumont BL, Handel MA. 2023. Reproductive genomics of the mouse: implications for human fertility and infertility. Development. Feb 15;150(4):dev201313. doi: 10.1242/dev.201313. Abstract

Heuer SE, Keezer KJ, Hewes AA, Onos KD, Graham KC, Howell GR, Bloss EB. 2023. Control of hippocampal synaptic plasticity by microglia-dendrite interactions depends on genetic context in mouse models of Alzheimer's disease. Alzheimers Dement. Sep 27. doi: 10.1002/alz.13440. Abstract

Schwartz LS, Young KA, Stearns TM, Boyer N, Mujica KD, Trowbridge JJ. 2023. Transcriptional and functional consequences of oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells. Exp Hematol. Nov 22:S0301-472X(23)01768-X. doi: 10.1016/j.exphem.2023.11.005. Abstract

Tyler AL, Spruce C, Kursawe R, Haber A, Ball RL, Pitman WA, Fine AD, Raghupathy N, Walker M, Philip VM, Baker CL, Mahoney JM, Churchill GA, Trowbridge JJ, Stitzel ML, Paigen K, Petkov PM, Carter GW. 2023. Variation in histone configurations correlates with gene expression across nine inbred strains of mice. Genome Res. Jun;33(6):857-871. doi: 10.1101/gr.277467.122. Abstract

2022

Arora UP, Dumont BL. 2022. Meiotic drive in house mice: mechanisms, consequences, and insights for human biology. Chromosome Res. Jul 13. doi: 10.1007/s10577-022-09697-2. Abstract

Byers C, Spruce C, Fortin HJ, Hartig EI, Czechanski A, Munger SC, Reinholdt LG, Skelly DA, Baker CL. 2022. Genetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cells. EMBO J. Dec 21:e109445. doi: 10.15252/embj.2021109445. Abstract

Foley KE, Hewes AA, Garceau DT, Kotredes KP, Carter GW, Sasner M, Howell GR. 2022. The APOEε3/ε4 genotype drives distinct gene signatures in the cortex of young mice. Front Aging Neurosci. Mar 16;14:838436. doi: 10.3389/fnagi.2022.838436. Abstract

Foley KE, Diemler CA, Hewes AA, Garceau DT, Sasner M, Howell GR. 2022. APOE ε4 and exercise interact in a sex-specific manner to modulate dementia risk factors. Alzheimers Dement. Jun 29;8(1):e12308. doi: 10.1002/trc2.12308. Abstract

Lawal RA, Mathis VL, Barter ME, Charette JR, Garretson A, Dumont BL.. 2022. Taxonomic assessment of two wild house mouse subspecies using whole-genome sequencing. Sci Rep. Dec 2;12(1):20866. doi: 10.1038/s41598-022-25420-x. Abstract

Parker CC, Philip VM, Gatti DM, Kasparek S, Kreuzman AM, Kuffler L, Mansky B, Masneuf S, Sharif K, Sluys E, Taterra D, Taylor WM, Thomas M, Polesskaya O, Palmer AA, Holmes A, Chesler EJ. 2022. Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. Alcohol Clin Exp Res. Jun;46(6):941-960. doi: 10.1111/acer.14825. Abstract

Reagan AM, Onos KD, Heuer SE, Sasner M, Howell GR. 2022. Improving mouse models for the study of Alzheimer's disease. Curr Top Dev Biol. 2022;148:79-113. doi: 10.1016/bs.ctdb.2021.12.005. Abstract

SanMiguel JM, Eudy E, Loberg MA, Young KA, Mistry JJ, Mujica KD, Schwartz LS, Stearns TM, Challen GA, Trowbridge JJ.. 2022. Distinct tumor necrosis factor alpha receptors dictate stem cell fitness versus lineage output in Dnmt3a-mutant clonal hematopoiesis. Cancer Discov. Dec 2;12(12):2763-2773. doi: 10.1158/2159-8290.CD-22-0086. Abstract

2021

Arora UP, Charlebois C, Lawal RA, Dumont BL. 2021. Population and subspecies diversity at mouse centromere satellites. BMC Genomics. 22(1):279. doi: 10.1186/s12864-021-07591-5. Abstract

Forte E, McLellan MA, Skelly DA, Rosenthal NA. 2021. Ex uno, plures - From one tissue to many cells: A review of single-cell transcriptomics in cardiovascular biology. Int J Mol Sci. 22: 2071. Abstract

Kingsmore KM, Bachali P, Catalina MD, Daamen AR, Heuer SE, Robl RD, Grammer AC, Lipsky PE. 2021. Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus. Sci Rep. Jul 20;11(1):14789. doi: 10.1038/s41598-021-93034-w. Abstract

Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR. Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H. Front Aging Neurosci. Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524. Abstract

Lawal RA, Arora UP, Dumont BL. 2021. Selection shapes the landscape of functional variation in wild house mice. BMC Biol. Nov 19;19(1):239. doi: 10.1186/s12915-021-01165-3. Abstract

Swanzey E, O'Connor C, Reinholdt LG. 2021. Mouse genetic reference populations: Cellular platforms for integrative systems genetics. Trends Genet. 2021 Mar;37(3):251-265. Abstract

Tolman NG, Balasubramanian R, Macalinao DG, Kearney AL, MacNicoll KH, Montgomery CL, de Vries WN, Jackson IJ, Cross SH, Kizhatil K, Nair KS, John SWM. 2021. Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice. Dis Model Mech. Feb 19;14(2):dmm046953. doi: 10.1242/dmm.046953. Abstract

2020

Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA; MODEL-AD Consortium, Carter GW. 2020. A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease. Mol Neurodegener. Nov 10;15(1):67.doi: 10.1186/s13024-020-00412-5. Abstract

Heuer SE, Neuner SM, Hadad N, O'Connell KMS, Williams RW, Philip VM, Gaiteri C, Kaczorowski CC. 2020. Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice. Learn Mem. Aug 17;27(9):355-371. doi: 10.1101/lm.051839.120. Abstract

Jackson HM, Foley KE, O'Rourke R, Stearns TM, Fathalla D, Morgan BP, Howell GR. 2020. A novel mouse model expressing human forms for complement receptors CR1 and CR2. BMC Genet. 21: 101. doi: 10.1186/s12863-020-00893-9. Abstract

Labelle-Dumais C, Pyatla G, Paylakhi S, Tolman NG, Hameed S, Seymens Y, Dang E, Mandal AK, Senthil S, Khanna RC, Kabra M, Kaur I, John SWM, Chakrabarti S, Nair KS. 2020. Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure. Dis Model Mech. May 29;13(5):dmm042853. doi: 10.1242/dmm.042853. Abstract

Skelly DA, Czechanski A, Byers C, Aydin S, Spruce C, Olivier C, Choi K, Gatti DM, Raghupathy N, Keele GR, Stanton A, Vincent M, Dion S, Greenstein I, Pankratz M, Porter DK, Martin W, O'Connor C, Qin W, Harrill AH, Choi T, Churchill GA, Munger SC, Baker CL, Reinholdt LG. 2020. Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State Pluripotency. Cell Stem Cell. Sep 3;27(3):459-469.e8. Abstract

Young K, Loberg MA, Eudy E, Schwartz LS, Mujica KD, Trowbridge JJ. 202. Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias. Exp Hematol. Sep;89:61-67.e3. doi: 10.1016/j.exphem.2020.07.012. Abstract

2019

Bhattacharyya T, Walker M, Powers NR, Brunton C, Fine AD, Petkov PM, Handel MA. 2019. Prdm9 and meiotic cohesin proteins cooperatively promote DNA double-strand break formation in mammalian spermatocytes. Curr Biol. 29: 1002-1018. Abstract

Buchanan RA, Foley KE, Pepper KW, Reagan AM, Keezer KJ, Hewes AA, Diemler CA, Preuss C, Soto I, John SWM, Howell GR. 2019. Meox2 haploinsufficiency accelerates axonal degeneration in DBA/2J glaucoma. Invest Ophthalmol Vis Sci. 60: 3238-3296. Abstract

Fine AD, Ball RL, Fujiwara Y, Handel MA, Carter GW. 2019. Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis. Mol Biol Cell. 30: 717-728. Abstract

Foley KE, Yang HS, Graham LC, Howell GR. 2019. Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice. BMC Genomics. Nov 14;20(1):860. doi: 10.1186/s12864-019-6230-z. Abstract

Graham LC, Grabowska WA, Chun Y, Risacher SL, Philip VM, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative (ADNI), Sukoff Rizzo SJ, Howell GR. 2019. Exercise prevents obesity-induced cognitive decline and white matter damage in mice. Neurobiol Aging. 80: 154-172. Abstract

Neuner SM, Heuer SE, Zhang JG, Philip VM, Kaczorowski CC. 2019. dentification of pre-symptomatic gene signatures that predict resilience to cognitive decline in the genetically diverse AD-BXD model. Front Genet. 10:35. Abstract

Neuner SM, Heuer SE, Huentelman MJ, O'Connell KMS, Kaczorowski CC. 2019. Harnessing genetic complexity to enhance translatability of Alzheimer's disease mouse models: A path toward precision medicine. Neuron 101:399-411. Abstract

Williams PA, Braine CE, Kizhatil K, Foxworth NE, Tolman NG, Harder JM, Scott RA, Sousa GL, Panitch A, Howell GR, John SWM. 2019. Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma. Mol Neurodegener. 14: 6. Abstract