Immunology Student Publications

Publication in peer-reviewed journals is a very important part of graduate training. Publications by Immunology students over the past five years are listed below. The names of student authors are in bold font.

2024

Bayer AL, Padilla-Rolon D, Smolgovsky S, Hinds P, Alcaide P. 2024. Deletion of MyD88 in T-cells improves anti-tumor activity in melanoma. Am J Pathol. Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Abstract

Jetton D, Muendlein HI, Connolly WM, Magri Z, Smirnova I, Batorsky R, Mecsas J, Degterev A, Poltorak A. 2024. Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection. Cell Rep. Aug 27;43(8):114641. doi: 10.1016/j.celrep.2024.114641. Abstract

Magri Z, Jetton D, Muendlein HI, Connolly WM, Russell H, Smirnova I, Sharma S, Bunnell S, Poltorak A. 2024. CD14 is a decision-maker between Fas-mediated death and inflammation. CD14 is a decision-maker between Fas-mediated death and inflammation. Cell Rep. Aug 29;43(9):114685. doi: 10.1016/j.celrep.2024.114685. Abstract

Parthasarathy S, Moreno de Lara L, Carrillo-Salinas FJ, Werner A, Borchers A, Iyer V, Vogell A, Fortier JM, Wira CR, Rodriguez-Garcia M. 2024. Human genital dendritic cell heterogeneity confers differential rapid response to HIV-1 exposure. Front Immunol. Oct 25;15:1472656. doi: 10.3389/fimmu.2024.1472656. Abstract

Xu S, Tan S, Romanos P, Reedy JL, Zhang Y, Mansour MK, Vyas JM, Mecsas J, Mou H, Leong JM. 2024. Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia. mBio. Aug 9:e0185624. doi: 10.1128/mbio.01856-24. Abstract

2023

Bayer AL, Smolgovsky S, Ngwenyama N, Hernández-Martínez A, Kaur K, Sulka K, Amrute J, Aronovitz M, Lavine K, Sharma S, Alcaide P. 2023. T-cell MyD88 is a novel regulator of cardiac fibrosis through modulation of T-Cell activation. Circ Res. Jul 26. doi: 10.1161/CIRCRESAHA.123.323030. Abstract

Fletcher EK, Ngwenyama N, Nguyen N, Turner SE, Covic L, Alcaide P, Kuliopulos A. 2023. Suppression of heart failure with PAR1 pepducin technology in a pressure overload model in mice. Circ Heart Fail. Jul 21:e010621. doi: 10.1161/CIRCHEARTFAILURE.123.010621. Abstract

Greenstein T, Aldridge BB. 2023. Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis. Front Cell Infect Microbiol. Jan 6;12:1085946. doi: 10.3389/fcimb.2022.1085946. Abstract

Janakiraman S, Engels S, Nanda P, Budak M, Greenstein T, Moraes MP, Aldridge BB, Kirschner DE. 2023. Semi-automated colony-forming unit counting for biosafety level 3 laboratories. STAR Protoc. Aug 6;4(3):102442. doi: 10.1016/j.xpro.2023.102442. Abstract

Magri Z, Poltorak A. 2023. You had me at PELO: a "Ribosome Rescuer" induces NLR inflammasome assembly. Cell Mol Immunol. Jun 27. doi: 10.1038/s41423-023-01059-0. Abstract

Moreno de Lara L, Werner A, Borchers A, Carrillo-Salinas FJ, Marmol W, Parthasarathy S, Iyer V, Vogell A, Illanes D, Abadía-Molina AC, Ochsenbauer C, Wira CR, Rodriguez-Garcia M. 2023. Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues. Front Immunol. Nov 15;14:1256182. doi: 10.3389/fimmu.2023.1256182. Abstract

Parthasarathy S, Shen Z, Carrillo-Salinas FJ, Iyer V, Vogell A, Illanes D, Wira CR, Rodriguez-Garcia M. 2023. Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa. Immun Ageing. Jul 14;20(1):34. doi: 10.1186/s12979-023-00360-w. Abstract

Petnicki-Ocwieja T, McCarthy JE, Powale U, Langston PK, Helble JD, Hu LT. 2023. Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation. PLoS Pathog. Dec 29;19(12):e1011886. doi: 10.1371/journal.ppat.1011886. Abstract

Smolgovsky S, Bayer AL, Kaur K, Sanders E, Aronovitz M, Filipp ME, Thorp EB, Schiattarella GG, Hill JA, Blanton RM, Cubillos-Ruiz JR, Alcaide P. 2023. Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction. J Clin Invest. Oct 24:e171874. doi: 10.1172/JCI171874. Abstract

Smolgovsky S, Theall B, Wagner N, Alcaide P. 2023. Fibroblasts and immune cells: At the cross-road of organ inflammation and fibrosis. Am J Physiol Heart Circ Physiol. Dec 1. doi: 10.1152/ajpheart.00545.2023. Abstract

Zambrano MA, Alcaide P. 2023. Immune cells in cardiac injury repair and remodeling. Curr Cardiol Rep. Mar 24. doi: 10.1007/s11886-023-01854-1. Abstract

2022

Bayer AL, Pietruska J, Farrell J, McRee S, Alcaide P, Hinds PW. 2022. AKT1 is required for a complete palbociclib-induced senescence phenotype in BRAF-V600E-driven human melanoma. Cancers. Jan 23;14(3):572. doi: 10.3390/cancers14030572. Abstract

Carrillo-Salinas FJ, Parthasarathy S, Moreno de Lara L, Borchers A, Ochsenbauer C, Panda A, Rodriguez-Garcia M. 2022. Short-chain fatty acids impair neutrophil antiviral function in an age-dependent manner. Cells. 11(16):2515. doi: 10.3390/cells11162515. Abstract

Helble JD, McCarthy JE, Sawden M, Starnbach MN, Hu LT. 2022. The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance. PLoS Pathog. Oct 20;18(10):e1010903. doi: 10.1371/journal.ppat.1010903. Abstract

Lamisere H, Bhalchandra S, Kane AV, Zeng XL, Mo D, Adams W, Estes MK, Ward HD. 2022. Differential response to the course of Cryptosporidium parvum infection and its impact on epithelial integrity in differentiated versus undifferentiated human intestinal enteroids. Infect Immun. Oct 26:e0039722. doi: 10.1128/iai.00397-22. Abstract

Muendlein HI, Connolly WM, Magri Z, Jetton D, Smirnova I, Degterev A, Balachandran S, Poltorak A. 2022. ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF. Proc Natl Acad Sci U S A. Jun 14;119(24):e2113872119. doi: 10.1073/pnas.2113872119. Abstract

Ngwenyama N, Kaur K, Bugg D, Theall B, Aronovitz M, Berland R, Panagiotidou S, Genco C, Perrin MA, Davis J, Alcaide P. 2022. Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction. Nat Cardiovasc Res. Aug;1(8):761-774. doi: 10.1038/s44161-022-00116-7. Abstract

Petnicki-Ocwieja T, Sharma B, Powale U, Pathak D, Tan S, Hu LT. 2022. An AP-3 dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling. Traffic. Oct 12. doi: 10.1111/tra.12870. Abstract

Tabtieng T, Lent RC, Kaku M, Monago Sanchez A, Gaglia MM. 2022. Caspase-mediated regulation and cellular heterogeneity of the cGAS/STING pathway in Kaposi's sarcoma-associated herpesvirus infection. mBio. Oct 18:e0244622. doi: 10.1128/mbio.02446-22. Abstract

Theall B, Alcaide P. 2022. The heart under pressure: immune cells in fibrotic remodeling. Curr Opin Physiol. Feb;25:100484. doi: 10.1016/j.cophys.2022.100484. Abstract

2021

Anastasiou M, Newton GA, Kaur K, Carrillo-Salinas FJ, Smolgovsky SA, Bayer AL, Ilyukha V, Sharma S, Poltorak A, Luscinskas FW, Alcaide P. 2021. Endothelial STING controls T-cell transmigration in an IFN-I dependent manner. JCI Insight. 22:149346. doi: 10.1172/jci.insight.149346. Abstract

Bayer AL, Alcaide P. 2021. MyD88: At the heart of inflammatory signaling and cardiovascular disease. J Mol Cell Cardiol. Aug 6:S0022-2828(21)00154-1. doi: 10.1016/j.yjmcc.2021.08.001. Abstract

Davis K, Greenstein T, Viau Colindres R, Aldridge BB. 2021. Leveraging laboratory and clinical studies to design effective antibiotic combination therapy. Curr Opin Microbiol. 64:68-75. doi: 10.1016/j.mib.2021.09.006. Abstract

Eidell KP, Lovy A, Sylvain NR, Scangarello FA, Muendlein HI, ,Ophir MJ, Nguyen K, Seminario MC, Bunnell SC. 2021. LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors. J Cell Sci. 19:jcs.258602. doi: 10.1242/jcs.258602. Abstract

Fasciano AC, Dasanayake GS, Estes MK, Zachos NC, Breault DT, Isberg RR, Tan S, Mecsas J. 2021. Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers. Gut Microbes. 13(1):1988390. doi: 10.1080/19490976.2021.1988390. Abstract

Kaur K, Velázquez FE, Anastasiou M, Ngwenyama N, Smolgovsky S, Aronovitz M, Alcaide P. 2021. Sialomucin CD43 plays a deleterious role in the development of experimental heart failure induced by pressure overload by modulating cardiac inflammation and fibrosis. Front Physiol. 12:780854. doi: 10.3389/fphys.2021.780854. Abstract

Larkins-Ford J, Greenstein T, Van N, Degefu YN, Olson MC, Sokolov A, Aldridge BB. 2021. Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis. Cell Syst. Aug 21:S2405-4712(21)00292-1. doi: 10.1016/j.cels.2021.08.004. Abstract

Joma BH, Siwapornchai N, Vanguri VK, Shrestha A, Roggensack SE, Davidson BA, Tai AK, Hakansson AP, Meydani SN, Leong JM, Bou Ghanem EN. 2021. A murine model for enhancement of Streptococcus pneumoniae pathogenicity upon viral infection and advanced age. Infect Immun. 24:IAI.00471-20. doi: 10.1128/IAI.00471-20. Abstract

Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. 2021. ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nat Commun. 12(1):86. doi: 10.1038/s41467-020-20357-z. Abstract

Ngwenyama N, Kirabo A, Aronovitz M, Velázquez F, Carrillo-Salinas F, Salvador AM, Nevers T, Amarnath V, Tai A, Blanton RM, Harrison DG, Alcaide P. 2021. Isolevuglandin-modified cardiac proteins drive CD4+ T cell activation in the heart and promote cardiac dysfunction. Circulation. doi: 10.1161/CIRCULATIONAHA.120.051889. Abstract

Setaro AC, Gaglia MM. 2021. All hands on deck: SARS-CoV-2 proteins that block early anti-viral interferon responses. Curr Res Virol Sci. Nov 12:100015. doi: 10.1016/j.crviro.2021.100015. Abstract

Smolgovsky S, Ibeh U, Tamayo TP, Alcaide P. 2021. Adding insult to injury - Inflammation at the heart of cardiac fibrosis. Cell Signal.6:109828. doi: 10.1016/j.cellsig.2020.109828. Abstract

Williams L, Bagley J, Iacomini J. 2021. The role of IL-6 in hyperlipidemia induced accelerated rejection. Am J Transplant. Sep 22. doi: 10.1111/ajt.16852. Abstract

2020

Bhalchandra S, Lamisere H, Ward H. 2020. Intestinal organoid/enteroid-based models for Cryptosporidium. Curr Opin Microbiol. 58: 124-129. Abstract

Cameron J, Martino P, Nguyen L, Li X. 2020. Cutting Edge: CRISPR-based transcriptional regulators reveal transcription-dependent establishment of epigenetic memory of Foxp3 in regulatory T cells. J Immunol. 2:ji2000537. doi: 10.4049/jimmunol.2000537. Abstract

Cardenas D, Bhalchandra S, Lamisere H, Chen Y, Zeng XL, Ramani S, Karandikar UC, Kaplan DL, Estes MK, Ward HD. 2020. Two- and three-dimensional bioengineered human intestinal tissue models for Cryptosporidium. Methods Mol Biol. 2052:373-402. Abstract

Carrillo-Salinas FJ, Anastasiou M, Ngwenyama N, Kaur K, Tai A, Smolgovsky SA, Jetton D, Aronovitz M, Alcaide P. 2020. Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner. Gut Microbes 12: 1-20. Abstract

de Lara LM, Parthasarathy RS, Rodriguez-Garcia M. 2021. Mucosal immunity and HIV acquisition in women. Curr Opin Physiol. 19: 32-38. Abstract

Fasciano AC, Mecsas J. 2020. Eat your Vitamin A: A role for retinoic acid in the development of M cells. Gastroenterology pii: S0016-5085(20)30652-1. doi: 10.1053/j.gastro.2020.05.029. Abstract

Fray MA, Charpentier JC, Sylvain NR, Seminario MC, Bunnell SC. 2020. Vav2 lacks calcium entry-promoting scaffolding functions unique to Vav1 and inhibits T cell activation via Cdc42. J Cell Sci. pii: jcs.238337. doi: 10.1242/jcs.238337. Abstract

Jamali A, Kenyon B, Ortiz G, Abou-Slaybi A, Sendra VG, Harris DL, Hamrah P. 2020. Plasmacytoid dendritic cells in the eye. Prog Retin Eye Res. 24:100877. doi: 10.1016/j.preteyeres.2020.100877. Abstract

Moir DT, Bowlin NO, Berube BJ, Yabut J, Mills DM, Nguyen GT, Aron ZD, Williams JD, Mecsas J, Hauser AR, Bowlin TL. 2020. A structure-function-inhibition analysis of the P. aeruginosa Type III secretion needle protein PscF. J Bacteriol. pii: JB.00055-20. doi: 10.1128/JB.00055-20. Abstract

Muendlein HI*, Sarhan J*, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, Sonenberg N, Degterev A, Poltorak A. 2020. Constitutive interferon attenuates RIPK1/3-mediated cytokine translation. Cell Rep. 30: 699-713. * Equal contribution. Abstract

Muendlein HI, Jetton D, Connolly WM, Eidell KP, Magri Z, Smirnova I, Poltorak A. 2020. cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation. Science 367: 1379-1384. Abstract

Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J. 2020. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. Elife pii: e56656. doi: 10.7554/eLife.56656. Abstract

Paczosa MK, Silver RJ, McCabe AL, Tai AK, McLeish CH, Lazinski DW, Mecsas J. 2020. Transposon mutagenesis screen of Klebsiella pneumoniae identifies multiple genes important for resisting antimicrobial activities of neutrophils in mice. Infect Immun. pii: IAI.00034-20. doi: 10.1128/IAI.00034-20. Abstract

Shaban L, Nguyen GT, Mecsas-Faxon BD, Swanson KD, Tan S, Mecsas J. 2020. Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection. PLoS Pathog. 16: e1008576. Abstract

Yoon JK, Holloway JR, Wells DW, Kaku M, Jetton D, Brown R, Coffin JM. 2020. HIV proviral DNA integration can drive T cell growth ex vivo. Proc Natl Acad Sci USA 117: 32880-32882. Abstract

2019

Bagley J, Williams L, Hyde M, Birriel CP, Iacomini J. 2019. Hyperlipidemia and allograft rejection. Curr Transpl Rep. 6: 90–98. 6: 90. https://doi.org/10.1007/s40472-019-0232-2.

Carrillo-Salinas FJ, Ngwenyama N, Anastasiou M, Kaur K, Alcaide P. 2019. Heart inflammation: immune cells roles and roads to the heart. Am J Pathol. 198: 1482-1494. Abstract

Fasciano AC, Mecsas J, Isberg RR. 2019. New age strategies to reconstruct mucosal tissue colonization and growth in cell culture systems. Microbiol Spectr. 7. doi: 10.1128/microbiolspec.BAI-0013-2019. Abstract

Fasciano AC, Blutt SE, Estes MK, Mecsas J. 2019. Induced differentiation of M cell-like cells in human stem cell-derived ileal enteroid monolayers. J Vis Exp.(149). doi: 10.3791/59894. Abstract

Nguyen GT, McCabe AL, Fasciano AC, Mecsas J. 2019. Detection of cells translocated with Yersinia Yops in infected tissues using β-lactamase fusions. Methods Mol Biol. 2010: 117-139. Abstract

Ledoux T, Aridgides D, Salvador R, Ngwenyama N, Panagiotidou S, Alcaide P, Blanton R, Perrin MA. 2019. Trypanosoma cruzi neurotrophic factor facilitates cardiac repair in a mouse model of chronic Chagas disease. J Pharmacol Exp Ther. 368: 11-20. Abstract

Ngwenyama N, Salvador AM, Velázquez F, Nevers T, Levy A, Aronovitz MJ, Luster AD, Huggins GS, Alcaide P. 2019. CXCR3 regulates CD4+ T cell cardiotropism in pressure overload induced cardiac dysfunction. JCI Insight 4 (7) pii: 125527. doi: 10.1172/jci.insight.125527. Abstract

Sarhan J, Liu BC, Muendlein HI, Weindel CG, Smirnova I, Tang AY, Ilyukha V, Sorokin M, Buzdin A, Fitzgerald KA, Poltorak A. 2019. Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ. 26: 332-347 Abstract

Silver RJ, Paczosa MK, McCabe AL, Balada-Llasat JM, Baleja JD, Mecsas J. 2019. Amino acid biosynthetic pathways are required for Klebsiella pneumoniae growth in immunocompromised lungs and are druggable targets during infection. Antimicrob Agents Chemother. 63(8):e02674-18. doi: 10.1128/AAC.02674-18.. Abstract

Velázquez FE, Anastasiou M, Carrillo-Salinas FJ, Ngwenyama N, Salvador AM, Nevers T, Alcaide P. 2019. Sialomucin CD43 regulates Th17 cell ICAM-1 dependent adhesion, apical migration and transendothelial migration. Immunology 157: 52-69. Abstract

2018

DeCicco RePass MA, Bhat N, Molinaro JH, Bunnell S, Cummings RD, Ward HD. 2018. Molecular cloning, expression, and characterization of UDP N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum. Mol Biochem Parasitol. 221: 56-65. Abstract

Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE, Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC, Stadecker MJ. 2018. CD209a synergizes with Dectin-2 and mincle to drive severe Th17 cell-mediated schistosome egg-induced immunopathology. Cell Rep. 22: 1288-1300. Abstract

Lewis JB, Scangarello FA, Murphy JM, Eidell KP, Sodipo MO, Ophir MJ, Sargeant R, Seminario MC, Bunnell SC. 2018. ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters. J Cell Sci. 13(21) pii: jcs215517. doi: 10.1242/jcs.21551. Abstract

Liu BC, Sarhan J, Poltorak A. 2018. Host-intrinsic interferon status in infection and immunity. Trends Mol Med. 24: 658-668. Abstract

Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A. 2018. Constitutive interferon maintains GBP expression required for release of bacterial components upstream of pyroptosis and anti-DNA responses. Cell Rep. 24: 155-168. Abstract

Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A. 2018. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci USA. 115: E10888-108987. Abstract

Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J. 2018. A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe 50: 85-92. Abstract