Genetics, Molecular & Cellular Biology Student Publications

Publication in peer-reviewed journals is a very important part of graduate training.

The Genetics, Molecular & Cell Biology program was created in 2023 when the Genetics and Cell, Molecular & Developmental Biology programs merged. Publications by students enrolled in these two programs over the past several years are listed below. The names of student authors are in bold font.

2025

Bloomer H, Dame HB, Parker SR, Oudin MJ. 2025. Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer. Cancer Metastasis Rev. 2025 Feb 11;44(1):31. doi: 10.1007/s10555-025-10249-3. Abstract

Brown RE, Coxon M, Larsen B, Allison M, Chadha A, Mittelstadt I, Mertz TM, Roberts SA, Freudenreich CH. 2025. APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2408179122. doi: 10.1073/pnas.2408179122. Abstract

Camarda ND, Lu Q, Tesfu AF, Liu RR, Ibarrola J, Jaffe IZ. Mineralocorticoid receptor in endothelial cells contributes to VEGF receptor inhibitor-induced vascular and kidney damage. Am J Hypertens. 2025 Jan 16;38(2):104-110. doi: 10.1093/ajh/hpae140. PMID: 39514632; PMCID: PMC11735467. Abstract

Dai B, Sperl AW, Polack L, Mejia I, Dame H, Huynh T, Deveney C, Lavoie N, Lee C, Doench JG, Daugherty MD, Heldwein EE. ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes. Nat Commun. 2025 Nov 21;16(1):10256. doi: 10.1038/s41467-025-65115-1. PMID: 41271665; PMCID: PMC12639132. Abstract

Dinsmore TC, Cortigiano JE, Xiang S, Spenciner MV, Dobbins AR, Zhao RL, Waldman BM, Beinborn M, Kumar K. 2025. Molecular Design of Unimolecular Tetra-Receptor Agonists. J Am Chem Soc. 2025 Jun 18;147(24):20819-20832. doi: 10.1021/jacs.5c04095. Epub 2025 Jun 3. PMID: 40461942; PMCID: PMC12560177. Abstract

Gao S, Weng B, Wich D, Power L, Chen M, Guan H, Ye Z, Xu C, Xu Q. Improving adenine base editing precision by enlarging the recognition domain of CRISPR-Cas9. Nat Commun. 2025 Feb 28;16(1):2081. doi: 10.1038/s41467-025-57154-5. PMID: 40021632; PMCID: PMC11871365. Abstract

Garcia JP, Armbruster M, Sommer M, Nunez-Beringer A, Dulla CG. 2025. Glutamate uptake is transiently compromised in the perilesional cortex following controlled cortical impact. Cereb Cortex. 2025 Feb 5;35(2):bhaf031. doi: 10.1093/cercor/bhaf031. Abstract

Gelbard MK, Grace M, von Schoeler-Ames A, Gnanou I, Munger K. The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7. Tumour Virus Res. 2025 Jun;19:200300. doi: 10.1016/j.tvr.2024.200300. Epub 2024 Dec 5. PMID: 39643241; PMCID: PMC11714379. Abstract

Hisey JA, Mahowald GK, Tolan NV, Kang P, Elshaboury RH, Dighe AS, Lewandrowski KB, Demetriou CA, Melanson SEF, Letourneau AR. Electronic tools to improve procalcitonin utilization. Antimicrob Steward Healthc Epidemiol. 2025 Feb 11;5(1):e33. doi: 10.1017/ash.2024.501. PMID: 39949997; PMCID: PMC11822617. Abstract

Khirallah J, Bloomer H, Wich D, Huang C, Workman JN, Li Y, Newby GA, Liu DR, Xu Q. 2025. In vivo base editing of Angptl3 via lipid nanoparticles to treat cardiovascular disease. Mol Ther Nucleic Acids. 2025 Feb 15;36(2):102486. doi: 10.1016/j.omtn.2025.102486. Abstract

Lopez KE, Meola DM, Camarda ND, Upshaw JN, Jaffe IZ, London CA, Yang VK. 2025. Effect of the Vascular Endothelial Growth Factor Inhibitor Toceranib on Cardiac Function and Endothelial Dysfunction Biomarkers in Dogs With Cancer. J Vet Intern Med. 2025 May-Jun;39(3):e70115. doi: 10.1111/jvim.70115. PMID: 40375566; PMCID: PMC12081826. Abstract

Martino N, Sanders EK, Bossardi Ramos R, Di John Portela I, Awadalla F, Lu S, Chuy D, Poddar N, Zuo MXG, Balasubramanian U, Vincent PA, Alcaide P, Adam AP. Endothelial STING and STAT1 mediate IFN-independent effects of IL-6 in an endotoxemia-induced model of shock. J Clin Invest. 2025 Sep 16;135(21):e189570. doi: 10.1172/JCI189570. PMID: 40956626; PMCID: PMC12578408. Abstract

Mills J, Tessari A, Anastas V, Sunilkumar D, Samadi Rad N, Lamba S, Cosentini I, Reers A, Zhu Z, Miles WO, Coppola V, Cocucci E, Magliery TJ, Shive H, Davies AE, Rizzotto L, Croce CM, Palmieri D. Acute degradation of nucleolin reveals its novel functions in cell cycle progression and cell division in triple negative breast cancer. J Exp Clin Cancer Res. 2025 Jul 14;44(1):204. doi: 10.1186/s13046-025-03401-y. PMID: 40653460; PMCID: PMC12257848. Abstract

Montes ID, Amirthagunanathan S, Ganji R, Paulo JA, Ahlstedt BA, Nguyen L, Joshi AS, Raman M. 2025. The p97 ATPase and its adaptor UBXD8 maintain peroxisome pools by preventing pexophagy. J Cell Biol. 2025 Sep 1;224(9):e202409024. doi: 10.1083/jcb.202409024. Abstract

Murimi-Worstell DA, Murimi-Worstell IB, Roy FM, Burn A, Freeman M, Puchalski RB, Coffin JM. 2025. In-depth analysis of endogenous retrovirus expression in glioblastoma. Mob DNA. 2025 Jul 16;16(1):29. doi: 10.1186/s13100-025-00365-w. Abstract

Parrish M, Traugh N, Seraj M, Kuperwasser C. Field cancerization, accelerated aging, and immunosuppression: the rapid rise of hormone-sensitive and early-onset breast cancer. NPJ Breast Cancer. 2025 Nov 18;11(1):128. doi: 10.1038/s41523-025-00840-w. PMID: 41253840; PMCID: PMC12627641. Abstract

Power L, Shuhmaher R, Houtz P, Chen J, Rudolph S, Yuen J, Machour M, Levy E, Wu L, Levenberg S, Whalen M, Chen Y, Kaplan DL. 3D Neurovascular Unit Tissue Model to Assess Responses to Traumatic Brain Injury. J Biomed Mater Res A. 2025 Jan;113(1):e37816. doi: 10.1002/jbm.a.37816. Epub 2024 Oct 23. PMID: 39440483. Abstract

Rauner G, Traugh NC, Trepicchio CJ, Parrish ME, Mushayandebvu K, Kuperwasser C. 2025. Single-cell organogenesis captures complex breast tissue formation in 3D. Development. 2025 Aug 6:dev.204813. doi: 10.1242/dev.204813. Abstract

Rennich BJ, Powers RM, Moores S, Hodul M, Juo P. 2025. The insulin-like peptide INS-27 mediates a muscle-to-neuron feedback signal coupling muscle activity with AMPA receptor trafficking. PLoS Genet. 2025 Jul 18;21(7):e1011786. doi: 10.1371/journal.pgen.1011786. Abstract

Sanders E, Kaur K, Wagner N, Emig R, Aronovitz M, Bayer AL, Theall B, Tai A, Martino N, Good ME, Adam AP, Blanton R, Alcaide P. 2025. Endothelial cell STING regulates IL6 production and is required for pathological cardiac hypertrophy and contractile dysfunction in experimental heart failure. Am J Pathol. 2025 Jul 8:S0002-9440(25)00236-6. doi: 10.1016/j.ajpath.2025.06.004. Abstract

Stepanian A, Travers RJ, Tesfu A, Wolter NL, Man JJ, Lu Q, Shamsuzzaman S, Deaton RA, Owens GK, Chen CS, Jaffe IZ. 2025. Ponatinib, But Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke. Circulation. 2025 Aug 5. doi: 10.1161/CIRCULATIONAHA.125.073610. Abstract

Travers RJ, Camarda N, Jaffe IZ, Lizcano RA, Upshaw JN. 2025. Permissive Cardiotoxicity and Determination of Anthracycline Risk With Previous Anthracycline Exposure. JACC Case Rep. 2025 Jul 9;30(18):104028. doi: 10.1016/j.jaccas.2025.104028. PMID: 40645690; PMCID: PMC12441384. Abstract

Trepicchio C, Rauner G, Traugh N, Wang R, Parrish M, Fein DEC, Mal Y, Gupta PB, Monti S, Kuperwasser C. 2025. DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation. Stem Cell Reports. 2025 Jun 24:102576. doi: 10.1016/j.stemcr.2025.102576. Abstract

Yesian AR, Chalom MM, Knudsen NH, Hyde AL, Personnaz J, Cho H, Liou YH, Starost KA, Lee CW, Tsai DY, Ho HW, Lin JS, Li J, Hu FB, Banks AS, Lee CH. Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity. J Clin Invest. 2025 Apr 8;135(11):e169152. PMID: 40198135; PMCID: PMC12126228. doi: 10.1172/JCI169152. Abstract

2024

Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M. 2024. UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation. EMBO Rep. Jan 2. doi: 10.1038/s44319-023-00027-z. Abstract

Barrios-Camacho CM, Zunitch MJ, Louie JD, Jang W, Schwob JE. 2024. An in vitro model of acute horizontal basal cell activation reveals gene regulatory networks underlying the nascent activation phase.Stem Cell Reports. Jul 12:S2213-6711(24)00191-7. doi: 10.1016/j.stemcr.2024.06.011. Abstract

Biwer LA, Man JJ, Camarda ND, Carvajal BV, Karumanchi SA, Jaffe IZ. 2024. Prior exposure to experimental preeclampsia increases atherosclerotic plaque inflammation in atherogenic mice. Arterioscler Thromb Vasc Biol. Mar 7. doi: 10.1161/ATVBAHA.123.320474. Abstract

Camarda ND, Ibarrola J, Biwer LA, Jaffe IZ. 2024. Mineralocorticoid receptors in vascular smooth muscle: Blood pressure and beyond. Hypertension. Mar 1. doi: 10.1161/HYPERTENSIONAHA.123.21358. Abstract

Champroux A, Tang Y, Dickson DA, Meng A, Harrington A, Liaw L, Marzi M, Nicassio F, Schlaeger TM, Feig LA. 2024. Transmission of reduced levels of miR-34/449 from sperm to preimplantation embryos is a key step in the transgenerational epigenetic inheritance of the effects of paternal chronic social instability stress. Epigenetics. Dec;19(1):2346694. doi: 10.1080/15592294.2024.2346694. Abstract

Conner SJ, Borges HB, Guarin JR, Gerton TJ, Yui A, Salhany KJ Jr, Mensah DN, Hamilton GA, Le GH, Lew KC, Zhang C, Oudin MJ. 2024. Obesity Induces Temporally Regulated Alterations in the Extracellular Matrix That Drive Breast Tumor Invasion and Metastasis. Cancer Res. 2024 Sep 4;84(17):2761-2775. doi: 10.1158/0008-5472.CAN-23-2526. Abstract

Conner SJ, Guarin JR, Le TT, Fatherree JP, Kelley C, Payne SL, Parker SR, Bloomer H, Zhang C, Salhany K, McGinn RA, Henrich E, Yui A, Srinivasan D, Borges H, Oudin MJ. 2024. Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential. Breast Cancer Res. 2024 Mar 11;26(1):43. doi: 10.1186/s13058-024-01796-8. Abstract

Gao S, Guan H, Bloomer H, Wich D, Song D, Khirallah J, Ye Z, Zhao Y, Chen M, Xu C, Liu L, Xu Q. 2024. Harnessing non-Watson-Crick's base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells. Proc Natl Acad Sci U S A. Jan 9;121(2):e2308415120. doi: 10.1073/pnas.2308415120. Abstract

Gautam A, Boyd DF, Nikhar S, Zhang T, Siokas I, Van de Velde LA, Gaevert J, Meliopoulos V, Thapa B, Rodriguez DA, Cai KQ, Yin C, Schnepf D, Beer J, DeAntoneo C, Williams RM, Shubina M, Livingston B, Zhang D, Andrake MD, Lee S, Boda R, Duddupudi AL, Crawford JC, Vogel P, Loch C, Schwemmle M, Fritz LC, Schultz-Cherry S, Green DR, Cuny GD, Thomas PG, Degterev A, Balachandran S. 2024. Necroptosis blockade prevents lung injury in severe influenza. Nature. Apr 10. doi: 10.1038/s41586-024-07265-8. Abstract

Gelbard MK, Grace M, von Schoeler-Ames A, Gnanou I, Munger K. 2024. The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7. Tumour Virus Res. Dec 4:200300. doi: 10.1016/j.tvr.2024.200300. Abstract

Graber JH, Hoskinson D, Liu H, Kaczmarek Michaels K, Benson PS, Maki NJ, Wilson CL, McGrath C, Puleo F, Pearson E, Kuehner JN, Moore C. 2024. Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response. Genetics. 2024 Feb 7;226(2):iyad199. doi: 10.1093/genetics/iyad199. Abstract

Hanada T, Empitu MA, Mines GI, Ma Q, Omorodion IL, Link A, Schwake CJ, Krueger RM, DaRosa NS, Levin AE, Vannier E, Chishti AH. Identification of Babesia microti immunoreactive antigens by phage display cDNA screen. Infect Immun. 2024 Jul 11;92(7):e0021524. doi: 10.1128/iai.00215-24. Epub 2024 Jun 17. PMID: 38884473; PMCID: PMC11238553. Abstract

Hershkovitz D, Chen EJ, Ensminger AW, Dugan AS, Conway KT, Joyce AC, Segal G, Isberg RR. 2024. Genetic evidence for a regulated cysteine protease catalytic triad in LegA7, a Legionella pneumophila protein that impinges on a stress response pathway. mSphere. Aug 21:e0022224. doi: 10.1128/msphere.00222-24. Abstract

Hill CJ, Datta S, McCurtin NP, Kimball HZ, Kingsley MC, Bayer AL, Martin AC, Peng Q, Weerapana E, Scheck RA. 2024. A Modular Turn-On Strategy to Profile E2-Specific Ubiquitination Events in Living Cells. Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202319579. doi: 10.1002/anie.202319579. Abstract

Hisey JA, Masnovo C, Mirkin SM. 2024. Triplex H-DNA structure: the long and winding road from the discovery to its role in human disease. NAR Mol Med. Dec 5;1(4):ugae024. doi: 10.1093/narmme/ugae024. Abstract

Hisey JA, Radchenko EA, Mandel NH, McGinty RJ, Matos-Rodrigues G, Rastokina A, Masnovo C, Ceschi S, Hernandez A, Nussenzweig A, Mirkin SM. 2024. Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Res. Feb 21:gkae124. doi: 10.1093/nar/gkae124. Abstract

Hollander JM, Goraltchouk A, Liu J, Xu E, Luppino F, McAlindon TE, Zeng L, Seregin A. 2024. Single injection AAV2-FGF18 gene therapy reduces cartilage loss and subchondral bone damage in a mechanically induced model of osteoarthritis. Curr Gene Ther. 2024;24(4):331-345. doi: 10.2174/0115665232275532231213063634. Abstract 

Jin S, Tian Y, Hacker J, Chen X, Bertolio M, Reynolds C, Jarvis R, Hu J, Promes V, Halim D, Gao FB, Yang Y. 2024. Inflammatory cytokines disrupt astrocyte exosomal HepaCAM-mediated protection against neuronal excitotoxicity in the SOD1G93A ALS model. Sci Adv. 2024 Nov 29;10(48):eadq3350. doi: 10.1126/sciadv.adq3350. Abstract

Lewis ED, Ortega EF, Dao MC, Barger K, Mason JB, Leong JM, Osburne MS, Magoun L, Nepveux FJ, Chishti AH, Schwake C, Quynh A, Gilhooly CH, Petty G, Guo W, Matuszek G, Pereira D, Reddy M, Wang J, Wu D, Meydani SN, Combs GF Jr. Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial - the safe iron study. Front Nutr. 2024 Feb 27;11:1376599. doi: 10.3389/fnut.2024.1376599.  Erratum for: Front Nutr. 2023 Oct 11;10:1230061. doi: 10.3389/fnut.2023.1230061. PMID: 38476600; PMCID: PMC10927985. Abstract

Li Z, Alshagawi MA, Oot RA, Alamoudi MK, Su K, Li W, Collins MP, Wilkens S, Forgac M. 2024. A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice. Oncotarget. Aug 14;15:575-587. doi: 10.18632/oncotarget.28638. Abstract

Malin J, Rosa-Birriel C, Hatini V. 2024. Pten, PI3K, and PtdIns(3,4,5)P3 dynamics control pulsatile actin branching in Drosophila retina morphogenesis. Dev Cell. Apr 17:S1534-5807(24)00203-X. doi: 10.1016/j.devcel.2024.03.035. Abstract

Mostafa SM, Moore C. Cleavage and polyadenylation factors are potential regulators of adipogenesis. BMC Res Notes. 2024 Sep 2;17(1):242. doi: 10.1186/s13104-024-06908-3. PMID: 39223634; PMCID: PMC11370009. Abstract

Mostafa SM, Wang L, Tian B, Graber J, Moore C. 2024. Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation. Sci Rep. 2024 Jul 23;14(1):16964. doi: 10.1038/s41598-024-67648-9. Abstract

Perreault LR, Daley MC, Watson MC, Rastogi S, Jaiganesh A, Porter EC, Duffy BM, Black LD 3rd. Characterization of cardiac fibroblast-extracellular matrix crosstalk across developmental ages provides insight into age-related changes in cardiac repair. Front Cell Dev Biol. 2024 Feb 16;12:1279932. doi: 10.3389/fcell.2024.1279932. PMID: 38434619; PMCID: PMC10904575. Abstract

Rosa-Birriel C, Malin J, Hatini V. 2024. Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis. J Cell Biol. Feb 5;223(2):e202304041. doi: 10.1083/jcb.202304041. Abstract

Schwake CJ, Krueger RM, Hanada T, Chishti AH. 2024. Plasmodium falciparum glutamic acid-rich protein (PfGARP)-independent polyclonal antibodies inhibit malaria parasite growth in human erythrocytes. J Infect Dis. Jan 31:jiae050. doi: 10.1093/infdis/jiae050. Abstract

Singh P, Jay DG.The Role of eHsp90 in extracellular matrix remodeling, tumor invasiveness, and metastasis. Cancers (Basel). 2024 Nov 19;16(22):3873. doi: 10.3390/cancers16223873. Abstract

Travers RJ, Stepanian A, Jaffe I. 2024. Endothelium as a source of cardiovascular toxicity from antitumor kinase inhibitors. Arterioscler Thromb Vasc Biol. Aug 15. doi: 10.1161/ATVBAHA.124.319864. Abstract

Williams ZH, Imedio AD, Gaucherand L, Lee DC, Mostafa SM, Phelan JP, Coffin JM, Johnson WE. Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element. Elife. 2024 Jul 22;13:e80216. doi: 10.7554/eLife.80216. PMID: 39037763; PMCID: PMC11379458. Abstract

2023

Biwer LA, Lu Q, Ibarrola J, Stepanian A, Man JJ, Carvajal BV, Camarda ND, Zsengeller Z, Skurnik G, Seely EW, Ananth Karumanchi S, Jaffe IZ.2023. Smooth muscle mineralocorticoid receptor promotes hypertension after preeclampsia. Circ Res. Feb 23. doi: 10.1161/CIRCRESAHA.122.321228. Abstract

Chavdoula E, Anastas V, La Ferlita A, Aldana J, Carota G, Spampinato M, Soysal B, Cosentini I, Parashar S, Sircar A, Nigita G, Sehgal L, Freitas MA, Tsichlis PN..2023. Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4. Metabolism. Nov 5:155719. doi: 10.1016/j.metabol.2023.155719. Abstract

Fritz DI, Ding Y, Merrill-Skoloff G, Flaumenhaft R, Hanada T, Chishti AH. 2023. Dematin regulates calcium mobilization, thrombosis, and early Akt activation in platelets. Mol Cell Biol. May 22:1-17. doi: 10.1080/10985549.2023.2210033. Abstract

Gelbard MK, Munger K. 2023. Human papillomaviruses: Knowns, mysteries, and unchartered territories. J Med Virol. Oct;95(10):e29191. doi: 10.1002/jmv.29191. Abstract

Graber JH, Hoskinson D, Liu H, Kaczmarek Michaels K, Benson PS, Maki NJ, Wilson CL, McGrath C, Puleo F, Pearson E, Kuehner JN, Moore C. 2023.Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response. Genetics. Nov 15:iyad199. doi: 10.1093/genetics/iyad199. Abstract

Jain A, Govindan R, Berkman AR, Luban J, Díaz-Salinas MA, Durham ND, Munro JB. 2023. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. PLoS Pathog. Dec 6;19(12):e1011848. doi: 10.1371/journal.ppat.1011848. Abstract

Lomoio S, Pandey RS, Rouleau N, Menicacci B, Kim W, Cantley WL, Haydon PG, Bennett DA, Young-Pearse TL, Carter GW, Kaplan DL, Tesco G. 2023. 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease. Mol Psychiatry. Jun 26. doi: 10.1038/s41380-023-02147-3. Abstract

Louie JD, Bromberg BH, Zunitch MJ, Schwob JE. 2023. Horizontal basal cells self-govern their neurogenic potential during injury-induced regeneration of the olfactory epithelium. Development. Jun 1:dev.201552. doi: 10.1242/dev.201552. Abstract

Matos-Rodrigues G, Hisey JA, Nussenzweig A, Mirkin SM. 2023. Detection of alternative DNA structures and its implications for human disease. Mol Cell. Oct 19;83(20):3622-3641. doi: 10.1016/j.molcel.2023.08.018. Abstract

McRee SK, Bayer AL, Pietruska J, Tsichlis PN, Hinds PW. 2023. AKT2 loss impairs BRAF-mutant melanoma metastasis. Cancers Oct 12;15(20):4958. doi: 10.3390/cancers15204958. Abstract .

Meng A, Ameroso D, Rios M. 2023. mGluR5 in astrocytes in the ventromedial hypothalamus regulates PACAP neurons and glucose homeostasis. J Neurosci. Jul 28:JN-RM-0193-23. doi: 10.1523/JNEUROSCI.0193-23.2023. Abstract

Moreno de Lara L, Werner A, Borchers A, Carrillo-Salinas FJ, Marmol W, Parthasarathy S, Iyer V, Vogell A, Illanes D, Abadía-Molina AC, Ochsenbauer C, Wira CR, Rodriguez-Garcia M. 2023. Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues. Front Immunol. Nov 15;14:1256182. doi: 10.3389/fimmu.2023.1256182. Abstract

Perera G, Power L, Larson A, Codden CJ, Awata J, Batorsky R, Strathdee D, Chin MT. 2023. Single cell transcriptomic analysis in a mouse model of Barth Syndrome reveals cell-specific alterations in gene expression and intercellular communication. Int J Mol Sci. Jul 18;24(14):11594. doi: 10.3390/ijms241411594. Abstract

Rennich BJ, Luth ES, Moores S, Juo P. 2023. Regulation of AMPA receptor trafficking by secreted protein factors. Front Cell Neurosic. Nov 27;17:1271169. doi: 10.3389/fncel.2023.1271169. Abstract

Ryner RF, Derera ID, Armbruster M, Kansara A, Sommer ME, Pirone A, Noubary F, Jacob M, Dulla CG. 2023. Cortical parvalbumin-positive interneuron development and function are altered in the APC conditional knockout mouse model of infantile and epileptic spasms syndrome. J Neurosci. Jan 30:JN-RM-0572-22. doi: 10.1523/JNEUROSCI.0572-22.2022. Abstract

Singh P, Ramanathan V, Zhang Y, Georgakoudi I, Jay DG. 2023. Extracellular Hsp90 binds to and aligns collagen-1 to enhance breast cancer cell invasiveness. Cancers (Basel) Oct 31;15(21):5237. doi: 10.3390/cancers15215237. Abstract

Wang Y, Travers RJ, Farrell A, Lu Q, Bays JL, Stepanian A, Chen C, Jaffe IZ. 2023. Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors. PLoS One. Nov 20;18(11):e0294438. doi: 10.1371/journal.pone.0294438. Abstract

Zunitch MJ, Fisch AS, Lin B, Barrios-Camacho CM, Faquin WC, Tachie-Baffour Y, Louie JD, Jang W, Curry WT, Gray ST, Lin DT, Schwob JE, Holbrook EH. 2023. Molecular evidence for olfactory neuroblastoma as a tumor of malignant globose basal cells. Mod Pathol. Feb 2;36(5):100122.gnant globose basal cells. Mod Pathol. Feb 2;36(5):100122. Abstract

2022

Ahlstedt BA, Ganji R, Raman M. The functional importance of VCP to maintaining cellular protein homeostasis. Biochem Soc Trans. Oct 5:BST20220648. doi: 10.1042/BST20220648. Abstract

Ameroso D, Meng A, Chen S, Felsted J, Dulla CG, Rios M. 2022. Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis. Nat Metab. May 2. doi: 10.1038/s42255-022-00566-0. Abstract

Armbruster M, Naskar S, Garcia JP, Sommer M, Kim E, Adam Y, Haydon PG, Boyden ES, Cohen AE, Dulla CG. 2022. Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes. Nat Neurosci. Apr 28. doi: 10.1038/s41593-022-01049-x. Abstract

Bayer AL, Pietruska J, Farrell J, McRee S, Alcaide P, Hinds PW. 2022. AKT1 is required for a complete palbociclib-induced senescence phenotype in BRAF-V600E-driven human melanoma. Cancers. Jan 23;14(3):572. doi: 10.3390/cancers14030572. Abstract

Brown RE, Su XA, Fair S, Wu K, Verra L, Jong R, Andrykovich K, Freudenreich CH. 2022. The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions. PLoS Biol. 27;20(12):e3001940. doi: 10.1371/journal.pbio.3001940. Abstract

Burn A, Roy F, Freeman M, Coffin JM. 2022. Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues. PLoS Biol. Oct 18;20(10):e3001826. doi: 10.1371/journal.pbio.3001826. Abstract

Camarda N, Travers R, Yang VK, London C, Jaffe IZ. 2022. VEGF receptor inhibitor-induced hypertension: emerging mechanisms and clinical implications. Curr Oncol Rep. Feb 18. doi: 10.1007/s11912-022-01224-0. Abstract

Davis-Knowlton J, Turner JE, Harrington A, Liaw L. 2022. Smooth muscle cell Notch2 is not required for atherosclerotic plaque formation in ApoE null mice. J Vasc Res. Jul 7:1-14. doi: 10.1159/000525258. Abstract

Fatherree JP, Guarin JR, McGinn RA, Naber SP, Oudin MJ. 2022. Chemotherapy-induced collagen IV drives cancer cell motility through activation of Src and focal adhesion kinase. Cancer Res. Mar 8:canres.1823.2021. doi: 10.1158/0008-5472.CAN-21-1823. Abstract

Gaun V, Martens JR, Schwob JE. 2022. Lifespan of mature olfactory sensory neurons varies with location in the mouse olfactory epithelium and age of the animal. J Comp Neurol. Apr 17. doi: 10.1002/cne.25330. Abstract

Guarin JR, Fatherree JP, Oudin MJ. 2022. Chemotherapy treatment induces pro-invasive changes in liver ECM composition. Matrix Biol. 44: 1161-1171. doi: 10.1016/j.matbio.2022.08.002. Abstract

Heller-Trulli D, Liu H, Mukherjee S, Moore CL.2022. UBE3D regulates mRNA 3'-end processing and maintains adipogenic potential in 3T3-L1 ells. Mol Cell Biol. Dec 15;42(12):e0017422. doi: 10.1128/mcb.00174-22. Abstract.

Hollander JM, Li L, Rawal M, Wang SK, Shu Y, Zhang M, Nielsen HC, Rosen CJ, Zeng L. 2022. A critical bioenergetic switch is regulated by IGF2 during murine cartilage development. Commun Biol. 5(1):1230. doi: 10.1038/s42003-022-04156-4. Abstract

Hui Mingalone CK, Nehme CR, Chen Y, Liu J, Longo BN, Garvey KD, Covello SM, Nielsen HC, James T, Messner WC, Zeng L. 2022. A novel whole "Joint-in-Motion" device reveals a permissive effect of high glucose levels and mechanical stress on joint destruction. Osteoarthritis Cartilage. S1063-4584(22)00914-1. doi: 10.1016/j.joca.2022.10.018. Abstract

Junier A, Weeks A, Alcaraz Y, Kumamoto CA. 2022. Bypass of Dfi1 regulation of Candida albicans invasive filamentation by iron limitation. mSphere. Feb 2:e0077921. doi: 10.1128/msphere.00779-21. Abstract

Liou YH, Personnaz J, Jacobi D, Knudsen NH, Chalom MM, Starost KA, Nnah IC, Lee CH. 2022. Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis. JCI Insight. Feb 22;7(4):e150041.doi: 10.1172/jci.insight.150041. Abstract

Lipo E, Asrat S, Huo W, Sol A, Fraser CS, Isberg RR. 2022. 5' untranslated mRNA regions allow bypass of host cell translation inhibition by Legionella pneumophila. Infect Immun. Nov 2:e0017922. doi: 10.1128/iai.00179-22. Abstract

Liu H, Heller-Trulli D, Moore CL. 2022. Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal. iScience. 2022 Jul 20;25(8):104804. doi: 10.1016/j.isci.2022.104804. Abstract

Malin J, Rosa Birriel C, Astigarraga S, Treisman JE, Hatini V. 2022. Sidekick dynamically rebalances contractile and protrusive forces to control tissue morphogenesis. J Cell Biol. 221(5):e202107035. doi: 10.1083/jcb.202107035. Abstract

Mithila F, Schwake C, Fang C, Merrill-Skoloff G, Covic L, Fritz DI, Hanada T, Flaumenhaft R, Chishti AH. 2022. Calpain-1 inhibition attenuates in vivo thrombosis in a humanized model of sickle cell disease. Thromb Res. Feb 4;211:123-126. doi: 10.1016/j.thromres.2022.01.029. Abstract

Nishijima H, Zunitch MJ, Yoshida M, Kondo K, Yamasoba T, Schwob JE, Holbrook EH. 2022. Rapid fluorescent vital imaging of olfactory epithelium. iScience. Apr 8;25(5):104222. doi: 10.1016/j.isci.2022.104222. Abstract

Porter EC, Stoppel WL, Kudej RK, Black LD 3rd. 2022. Right ventricular outflow tract surgical resection in young, large animal model for the study of alternative cardiovascular patches. Methods Mol Bio. 2485:299-309. doi: 10.1007/978-1-0716-2261-2_20. Abstract

Schwake C, Hyon M, Chishti AH. 2022. Signal peptide peptidase: A potential therapeutic target for parasitic and viral infections. Exp Opin Ther Targets. Mar 2. doi: 10.1080/14728222.2022.2047932. Abstract

Schwake C, McKay L, Griffiths A, Scartelli C, Flaumenhaft R, Chishti AH. 2022. BDA-410 inhibits SARS-CoV-2 main protease activity and viral replication in mammalian cells. J Cell Mol Med. Sep 9. doi: 10.1111/jcmm.17442. Abstract

Shuey MM, Xiang RR, Moss ME, Carvajal BV, Wang Y, Camarda N, Fabbri D, Rahman P, Ramsey J, Stepanian A, Sebastiani P, Wells QS, Beckman JA, Jaffe IZ. 2022. Systems approach to integrating preclinical apolipoprotein E-knockout investigations reveals novel etiologic pathways and master atherosclerosis network in humans. Arterioscler Thromb Vasc Biol. 42: 35-48. Abstract

Su K, Collins MP, McGuire CM, Alshagawi MA, Alamoudi MK, Li Z, Forgac M. 2022. Isoform a4 of the vacuolar ATPase a subunit promotes 4T1-12B breast cancer cell-dependent tumor growth and metastasis in vivo. J Biol Chem. Aug 18:102395. doi: 10.1016/j.jbc.2022.102395. Abstract

Sunkavalli A, McClure R, Genco C. 2022. Molecular regulatory mechanisms drive emergent pathogenetic properties of Neisseria gonorrhoeae. Microorganisms. Apr 28;10(5):922. doi: 10.3390/microorganisms10050922. Abstract

Thorsen MK, Draganova EB, Heldwein EE. 2022. The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. PLoS Pathog. Jul 8;18(7):e1010623. doi: 10.1371/journal.ppat.1010623. Abstract

Wolter NL, Jaffe IZ. 2022. Emerging vascular cell-specific roles for mineralocorticoid receptor: implications for understanding sex differences in cardiovascular disease. Am J Physiol Cell Physiol. Nov 28. doi: 10.1152/ajpcell.00372.2022. Abstract

Yang H, Yuan L, Ibaragi S, Li S, Shapiro R, Vanli N, Goncalves KA, Yu W, Kishikawa H, Jiang Y, Hu AJ, Jay D, Cochran B, Holland EC, Hu GF. 2022. Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival. Brit J Cancer. Aug;127(3):422-435. doi: 10.1038/s41416-022-01814-6. Abstract

Yeo AT, Rawal S, Delcuze B, Christofides A, Atayde A, Strauss L, Balaj L, Rogers VA, Uhlmann EJ, Varma H, Carter BS, Boussiotis VA, Charest A. 2022. Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression. Nat Immunol. May 27. doi: 10.1038/s41590-022-01215-0. Abstract

2021

Biwer LA, Carvajal BV, Lu Q, Man JJ, Jaffe IZ. 2021. Mineralocorticoid and estrogen receptors in endothelial cells coordinately regulate microvascular function in obese female mice. Hypertension. 77: 2117-2126. Abstract

Draganova EB, Thorsen MK, Heldwein EE. 2021. Nuclear egress. Curr Issues Mol Biol. 41: 125-170. Abstract

Eidell KP, Lovy A, Sylvain NR, Scangarello FA, Muendlein HI, Ophir MJ, Nguyen K, Seminario MC, Bunnell SC. 2021. LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors. J Cell Sci. 19:jcs.258602. doi: 10.1242/jcs.258602. Abstract

Garcia JP, Dulla CG. 2021. Oops!...Glutamate did it again. Epilepsy Curr. Oct 30;22(1):61-63. doi: 10.1177/15357597211055287. Abstract

Goodwill AG, Baker HE, Dick GM, McCallinhart PE, Bailey CA, Brown SM, Man JJ, Tharp DL, Clark HE, Blaettner BS, Jaffe IZ, Bowles DK, Trask AJ, Tune JD, Bender SB. 2021. Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in Kv channels. Basic Res Cardiol. 116(1):35. doi: 10.1007/s00395-021-00879-3. Abstract

Hasan N, Zhang Y, Georgakoudi I, Sonnenschein C, Soto AM. 2021. Matrix composition modulates vitamin D3's effects on 3D collagen fiber organization by MCF10A cells. Tissue Eng Part A. 27: 1399-1410. Abstract

Hilterbrand AT, Daly RE, Heldwein EE. 2021. Contributions of the four essential entry glycoproteins to HSV-1 tropism and the selection of entry routes. mBio. 12(2):e00143-21. doi: 10.1128/mBio.00143-21. Abstract

Hyde M, Bagley J, Hinds PW, Tsichlis P, Iacomini J. 2021. Hyperlipidemia induced metabolic changes in regulatory T cells result in altered function. Eur J Immunol. 51: 2577-2589. Abstract

Kim SK, Biwer LA, Moss ME, Man JJ, Aronovitz MJ, Martin GL, Carrillo-Salinas FJ, Salvador AM, Alcaide P, Jaffe IZ. 2021. Mineralocorticoid receptor in smooth muscle contributes to pressure overload-induced heart failure. Circ Heart Fail. 14(2):e007279. doi: 10.1161/CIRCHEARTFAILURE.120.007279. Abstract

Man JJ, Lu Q, Elizabeth Moss M, Carvajal B, Baur W, Garza AE, Freeman R, Anastasiou M, Ngwenyama N, Adler GK, Alcaide P, Jaffe IZ. 2021. Myeloid mineralocorticoid receptor transcriptionally regulates P-Selectin glycoprotein ligand-1 and promotes monocyte trafficking and atherosclerosis. Arterioscler Thromb Vasc Biol. 41: 2740-2755. Abstract

Menon DP, Qi G, Kim SK, Moss ME, Penumatsa KC, Warburton RR, Toksoz D, Wilson J, Hill NS, Jaffe IZ, Preston IR. 2021. Vascular cell-specific roles of mineralocorticoid receptors in pulmonary hypertension. Pulm Circ. Jun 18;11(3):20458940211025240. doi: 10.1177/20458940211025240. Abstract

Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. 2021. ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nat Commun. 12(1):86. doi: 10.1038/s41467-020-20357-z. Abstract

Murray LP, Govindan R, Mora AC, Munro JB, Mace CR. 2021. Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance. Anal Bioanal Chem. 413: 3695-3706. Abstract

Neil AJ, Hisey JA, Quasem I, McGinty RJ, Hitczenko M, Khristich AN, Mirkin SM. 2021. Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging. Proc Natl Acad Sci USA 118(5):e2013080118. doi: 10.1073/pnas.2013080118. Abstract

Nevola KT, Kiel DP, Zullo AR, Weiss S, Homuth G, Foessl I, Obermayer-Pietsch B, Motyl KJ, Lary CW. 2021. miRNA Mechanisms Underlying the association of beta blocker use and bone mineral density. J Bone Miner Res. 36: 110-112. Abstract

Pace JR, Lampkin BJ, Abakah C, Moyer A, Miao J, Deprey K, Cerulli RA, Lin YS, Baleja JD, Baker D, Kritzer JA. 2021. Stapled β-hairpins featuring 4-mercaptoproline. J Am Chem Soc. 143: 15039-15044. Abstract

Papadopoulos G, Berland R, Sunkavalli A, Coats SR, Darveau RP, Genco CA. 2021. Microbial lipid A remodeling controls cross-presentation efficiency and CD8 T cell priming by modulating dendritic cell function. Infect Immun. 89: e00335-20. doi: 10.1128/IAI.00335-20. Abstract

Park L, Luth ES, Jones K, Hofer J, Nguyen I, Watters KE, Juo P. 2021. The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans. PLoS One 16(2):e0245587. doi: 10.1371/journal.pone.0245587. Abstract

Polinski JM, Zimin AV, Clark KF, Kohn AB, Sadowski N, Timp W, Ptitsyn A, Khanna P, Romanova DY, Williams P, Greenwood SJ, Moroz LL, Walt DR, Bodnar AG. 2021. The American lobster genome reveals insights on longevity, neural, and immune adaptations. Sci Adv. 7(26):eabe8290. doi: 10.1126/sciadv.abe8290. Abstract

Siokas I, Zhang D, Poltorak A, Muendlein H, Degterev A. 2021. Immunoprecipitation strategies to isolate RIPK1/RIPK3 complexes in mouse macrophages. Curr Protoc. Jun;1(6):e156. doi: 10.1002/cpz1.156. Abstract

Smith A, Watkins T, Theocharidis G, Lang I, Leschinsky M, Maione A, Kashpur O, Raimondo T, Rahmani S, Baskin J, Mooney DJ, Veves A, Garlick J. 2021. A novel 3D skin disease model to assess macrophage function in diabetes.Tissue Eng Part C Methods. 27: 49058 Abstract

Thorsen MK, Lai A, Lee MW, Hoogerheide DP, Wong GCL, Freed JH, Heldwein EE. 2021. Highly basic clusters in the herpes simplex virus 1 nuclear egress complex drive membrane budding by inducing lipid ordering. mBio. 12:e0154821. doi: 10.1128/mBio.01548-21. Abstract

Yeo AT, Jun HJ, Appleman VA, Zhang P, Varma H, Sarkaria JN, Charest A. 2021. EGFRvIII tumorigenicity requires PDGFRA co-signaling and reveals therapeutic vulnerabilities in glioblastoma. Oncogene. 40: 2682-2696.