Genetics, Molecular & Cellular Biology Student Publications

Publication in peer-reviewed journals is a very important part of graduate training.

The Genetics, Molecular & Cell Biology program was created in 2023 when the Genetics and Cell, Molecular & Developmental Biology programs merged. Publications by students enrolled in these two programs over the past three years are listed below. The names of student authors are in bold font.

2024

Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M. 2024. UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation. EMBO Rep. Jan 2. doi: 10.1038/s44319-023-00027-z. Abstract

Barrios-Camacho CM, Zunitch MJ, Louie JD, Jang W, Schwob JE. 2024. An in vitro model of acute horizontal basal cell activation reveals gene regulatory networks underlying the nascent activation phase.Stem Cell Reports. Jul 12:S2213-6711(24)00191-7. doi: 10.1016/j.stemcr.2024.06.011. Abstract

Biwer LA, Man JJ, Camarda ND, Carvajal BV, Karumanchi SA, Jaffe IZ. 2024. Prior exposure to experimental preeclampsia increases atherosclerotic plaque inflammation in atherogenic mice. Arterioscler Thromb Vasc Biol. Mar 7. doi: 10.1161/ATVBAHA.123.320474. Abstract

Camarda ND, Lu Q, Tesfu AF, Liu RR, Ibarrola J, Jaffe IZ. 2024. Mineralocorticoid receptor in endothelial cells contributes to VEGF receptor inhibitor-induced vascular and kidney damage. Am J Hypertens. Nov 8:hpae140. doi: 10.1093/ajh/hpae140. Abstract 

Camarda ND, Lu Q, Meola DM, Man JJ, Song Z, Travers RJ, Lopez KE, Powers SN, Papanastasiou M, DeRuff KC, Mullahoo J, Egri SB, Davison D, Sebastiani P, Eblen ST, Buchsbaum R, Huggins GS, London CA, Jaffe JD, Upshaw JN, Yang VK, Jaffe IZ. 2024. Identifying mitigating strategies for endothelial cell dysfunction and hypertension in response to VEGF receptor inhibitors. Clin Sci (Lond). Sep 18;138(18):1131-1150. doi: 10.1042/CS20240537. Abstract.

Camarda ND, Ibarrola J, Biwer LA, Jaffe IZ. 2024. Mineralocorticoid receptors in vascular smooth muscle: Blood pressure and beyond. Hypertension. Mar 1. doi: 10.1161/HYPERTENSIONAHA.123.21358. Abstract

Champroux A, Tang Y, Dickson DA, Meng A, Harrington A, Liaw L, Marzi M, Nicassio F, Schlaeger TM, Feig LA. 2024. Transmission of reduced levels of miR-34/449 from sperm to preimplantation embryos is a key step in the transgenerational epigenetic inheritance of the effects of paternal chronic social instability stress. Epigenetics. Dec;19(1):2346694. doi: 10.1080/15592294.2024.2346694. Abstract

Diemler CA, MacLean M, Heuer SE, Hewes AA, Marola OJ, Libby RT, Howell GR. 2024. Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma. Front Aging Neurosci. Jul 2;16:1396443. doi: 10.3389/fnagi.2024.1396443. Abstract

Gao S, Guan H, Bloomer H, Wich D, Song D, Khirallah J, Ye Z, Zhao Y, Chen M, Xu C, Liu L, Xu Q. 2024. Harnessing non-Watson-Crick's base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells. Proc Natl Acad Sci U S A. Jan 9;121(2):e2308415120. doi: 10.1073/pnas.2308415120.  Abstract

Gautam A, Boyd DF, Nikhar S, Zhang T, Siokas I, Van de Velde LA, Gaevert J, Meliopoulos V, Thapa B, Rodriguez DA, Cai KQ, Yin C, Schnepf D, Beer J, DeAntoneo C, Williams RM, Shubina M, Livingston B, Zhang D, Andrake MD, Lee S, Boda R, Duddupudi AL, Crawford JC, Vogel P, Loch C, Schwemmle M, Fritz LC, Schultz-Cherry S, Green DR, Cuny GD, Thomas PG, Degterev A, Balachandran S. 2024. Necroptosis blockade prevents lung injury in severe influenza. Nature. Apr 10. doi: 10.1038/s41586-024-07265-8. Abstract

Graber JH, Hoskinson D, Liu H, Kaczmarek Michaels K, Benson PS, Maki NJ, Wilson CL, McGrath C, Puleo F, Pearson E, Kuehner JN, Moore C. 2024. Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response. Genetics. 2024 Feb 7;226(2):iyad199. doi: 10.1093/genetics/iyad199.  Abstract

Hartig EI, Day M, Jarysta A, Tarchini B. 2024. Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life. Proc Natl Acad Sci USA Oct;121(40):e2405455121. doi: 10.1073/pnas.2405455121. Abstract

Hershkovitz D, Chen EJ, Ensminger AW, Dugan AS, Conway KT, Joyce AC, Segal G, Isberg RR. 2024. Genetic evidence for a regulated cysteine protease catalytic triad in LegA7, a Legionella pneumophila protein that impinges on a stress response pathway. mSphere. Aug 21:e0022224. doi: 10.1128/msphere.00222-24. Abstract

Heuer SE, Bloss EB, Howell GR.. 2024. Strategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease. Neuropharmacology. May 3:109987. doi: 10.1016/j.neuropharm.2024.109987. Abstract

Hisey JA, Radchenko EA, Mandel NH, McGinty RJ, Matos-Rodrigues G, Rastokina A, Masnovo C, Ceschi S, Hernandez A, Nussenzweig A, Mirkin SM.. 2024. Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Res. Feb 21:gkae124. doi: 10.1093/nar/gkae124. Abstract

Hollander JM, Goraltchouk A, Liu J, Xu E, Luppino F, McAlindon TE, Zeng L, Seregin A. 2024. Single injection AAV2-FGF18 gene therapy reduces cartilage loss and subchondral bone damage in a mechanically induced model of osteoarthritis. Curr Gene Ther. 2024;24(4):331-345. doi: 10.2174/0115665232275532231213063634. Abstract 

Li Z, Alshagawi MA, Oot RA, Alamoudi MK, Su K, Li W, Collins MP, Wilkens S, Forgac M. 2024. A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice. Oncotarget. Aug 14;15:575-587. doi: 10.18632/oncotarget.28638. Abstract

Malin J, Rosa-Birriel C, Hatini V. 2024. Pten, PI3K, and PtdIns(3,4,5)P3 dynamics control pulsatile actin branching in Drosophila retina morphogenesis. Dev Cell. Apr 17:S1534-5807(24)00203-X. doi: 10.1016/j.devcel.2024.03.035. Abstract

Mostafa SM, Wang L, Tian B, Graber J, Moore C. 2024. Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation. Sci Rep. 2024 Jul 23;14(1):16964. doi: 10.1038/s41598-024-67648-9. Abstract

O'Connor C, Keele GR, Martin W, Stodola T, Gatti D, Hoffman BR, Korstanje R, Churchill GA, Reinholdt LG. 2024. Unraveling the genetics of arsenic toxicity with cellular morphology QTL. PLoS Genet. Apr 25;20(4):e1011248. doi: 10.1371/journal.pgen.1011248. Abstract

Rosa-Birriel C, Malin J, Hatini V. 2024. Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis. J Cell Biol. Feb 5;223(2):e202304041. doi: 10.1083/jcb.202304041. Abstract

Schwake CJ, Krueger RM, Hanada T, Chishti AH. 2024. Plasmodium falciparum glutamic acid-rich protein (PfGARP)-independent polyclonal antibodies inhibit malaria parasite growth in human erythrocytes. J Infect Dis. Jan 31:jiae050. doi: 10.1093/infdis/jiae050. Abstract

Singh P, Jay DG.The Role of eHsp90 in extracellular matrix remodeling, tumor invasiveness, and metastasis. Cancers (Basel). 2024 Nov 19;16(22):3873. doi: 10.3390/cancers16223873. Abstract

Travers RJ, Stepanian A, Jaffe I. 2024. Endothelium as a source of cardiovascular toxicity from antitumor kinase inhibitors. Arterioscler Thromb Vasc Biol. Aug 15. doi: 10.1161/ATVBAHA.124.319864. Abstract

Wells AE, Wilson JJ, Heuer SE, Sears JD, Wei J, Pandey R, Costa MW, Kaczorowski CC, Roopenian DC, Chang CH, Carter GW. 2024. Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice. PLoS One. Mar 7;19(3):e0299595. doi: 10.1371/journal.pone.0299595. Abstract

2023

Arora UP, Sullivan BA, Dumont BL. 2023. Variation in the CENP-A sequence association landscape across diverse inbred mouse strains.Cell Rep. Sep 23;42(10):113178. doi: 10.1016/j.celrep.2023.113178. Abstract

Biwer LA, Lu Q, Ibarrola J, Stepanian A, Man JJ, Carvajal BV, Camarda ND, Zsengeller Z, Skurnik G, Seely EW, Ananth Karumanchi S, Jaffe IZ.2023. Smooth muscle mineralocorticoid receptor promotes hypertension after preeclampsia. Circ Res. Feb 23. doi: 10.1161/CIRCRESAHA.122.321228. Abstract

Chavdoula E, Anastas V, La Ferlita A, Aldana J, Carota G, Spampinato M, Soysal B, Cosentini I, Parashar S, Sircar A, Nigita G, Sehgal L, Freitas MA, Tsichlis PN..2023. Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4. Metabolism. Nov 5:155719. doi: 10.1016/j.metabol.2023.155719. Abstract

Fritz DI, Ding Y, Merrill-Skoloff G, Flaumenhaft R, Hanada T, Chishti AH. 2023. Dematin regulates calcium mobilization, thrombosis, and early Akt activation in platelets. Mol Cell Biol. May 22:1-17. doi: 10.1080/10985549.2023.2210033. Abstract

Gambogi CW, Pandey N, Dawicki-McKenna JM, Arora UP, Liskovykh MA, Ma J, Lamelza P, Larionov V, Lampson MA, Logsdon GA, Dumont BL, Black BE. 2023. Centromere innovations within a mouse species. Sci Adv. Nov 17;9(46):eadi5764. doi: 10.1126/sciadv.adi5764. Abstract

Garretson A, Dumont BL, Handel MA. 2023. Reproductive genomics of the mouse: implications for human fertility and infertility. Development. Feb 15;150(4):dev201313. doi: 10.1242/dev.201313. Abstract

Gelbard MK, Munger K. 2023. Human papillomaviruses: Knowns, mysteries, and unchartered territories. J Med Virol. Oct;95(10):e29191. doi: 10.1002/jmv.29191. Abstract

Graber JH, Hoskinson D, Liu H, Kaczmarek Michaels K, Benson PS, Maki NJ, Wilson CL, McGrath C, Puleo F, Pearson E, Kuehner JN, Moore C. 2023.Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response. Genetics. Nov 15:iyad199. doi: 10.1093/genetics/iyad199. Abstract

Heuer SE, Nickerson EW, Howell GR, Bloss EB. 2023. Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits. Aging Cell. Dec 21:e14033. doi: 10.1111/acel.14033. Abstract

Heuer SE, Keezer KJ, Hewes AA, Onos KD, Graham KC, Howell GR, Bloss EB. 2023. Control of hippocampal synaptic plasticity by microglia-dendrite interactions depends on genetic context in mouse models of Alzheimer's disease. Alzheimers Dement. Sep 27. doi: 10.1002/alz.13440. Abstract

Jain A, Govindan R, Berkman AR, Luban J, Díaz-Salinas MA, Durham ND, Munro JB. 2023. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. PLoS Pathog. Dec 6;19(12):e1011848. doi: 10.1371/journal.ppat.1011848. Abstract

Lomoio S, Pandey RS, Rouleau N, Menicacci B, Kim W, Cantley WL, Haydon PG, Bennett DA, Young-Pearse TL, Carter GW, Kaplan DL, Tesco G. 2023. 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease. Mol Psychiatry. Jun 26. doi: 10.1038/s41380-023-02147-3. Abstract

Louie JD, Bromberg BH, Zunitch MJ, Schwob JE. 2023. Horizontal basal cells self-govern their neurogenic potential during injury-induced regeneration of the olfactory epithelium. Development. Jun 1:dev.201552. doi: 10.1242/dev.201552. Abstract

Matos-Rodrigues G, Hisey JA, Nussenzweig A, Mirkin SM. 2023. Detection of alternative DNA structures and its implications for human disease. Mol Cell. Oct 19;83(20):3622-3641. doi: 10.1016/j.molcel.2023.08.018. Abstract

McRee SK, Bayer AL, Pietruska J, Tsichlis PN, Hinds PW. 2023. AKT2 loss impairs BRAF-mutant melanoma metastasis. Cancers Oct 12;15(20):4958. doi: 10.3390/cancers15204958.  Abstract .

Meng A, Ameroso D, Rios M. 2023. mGluR5 in astrocytes in the ventromedial hypothalamus regulates PACAP neurons and glucose homeostasis. J Neurosci. Jul 28:JN-RM-0193-23. doi: 10.1523/JNEUROSCI.0193-23.2023. Abstract

Moreno de Lara L, Werner A, Borchers A, Carrillo-Salinas FJ, Marmol W, Parthasarathy S, Iyer V, Vogell A, Illanes D, Abadía-Molina AC, Ochsenbauer C, Wira CR, Rodriguez-Garcia M. 2023. Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues. Front Immunol. Nov 15;14:1256182. doi: 10.3389/fimmu.2023.1256182. Abstract

Perera G, Power L, Larson A, Codden CJ, Awata J, Batorsky R, Strathdee D, Chin MT. 2023. Single cell transcriptomic analysis in a mouse model of Barth Syndrome reveals cell-specific alterations in gene expression and intercellular communication. Int J Mol Sci. Jul 18;24(14):11594. doi: 10.3390/ijms241411594. Abstract

Rennich BJ, Luth ES, Moores S, Juo P. 2023. Regulation of AMPA receptor trafficking by secreted protein factors. Front Cell Neurosic. Nov 27;17:1271169. doi: 10.3389/fncel.2023.1271169. Abstract

Ryner RF, Derera ID, Armbruster M, Kansara A, Sommer ME, Pirone A, Noubary F, Jacob M, Dulla CG. 2023. Cortical parvalbumin-positive interneuron development and function are altered in the APC conditional knockout mouse model of infantile and epileptic spasms syndrome. J Neurosci. Jan 30:JN-RM-0572-22. doi: 10.1523/JNEUROSCI.0572-22.2022. Abstract

Schwartz LS, Young KA, Stearns TM, Boyer N, Mujica KD, Trowbridge JJ. 2023. Transcriptional and functional consequences of oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells. Exp Hematol. Nov 22:S0301-472X(23)01768-X. doi: 10.1016/j.exphem.2023.11.005. Abstract

Singh P, Ramanathan V, Zhang Y, Georgakoudi I, Jay DG. 2023. Extracellular Hsp90 binds to and aligns collagen-1 to enhance breast cancer cell invasiveness. Cancers (Basel) Oct 31;15(21):5237. doi: 10.3390/cancers15215237. Abstract

Wang Y, Travers RJ, Farrell A, Lu Q, Bays JL, Stepanian A, Chen C, Jaffe IZ. 2023. Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors. PLoS One. Nov 20;18(11):e0294438. doi: 10.1371/journal.pone.0294438. Abstract

Zunitch MJ, Fisch AS, Lin B, Barrios-Camacho CM, Faquin WC, Tachie-Baffour Y, Louie JD, Jang W, Curry WT, Gray ST, Lin DT, Schwob JE, Holbrook EH. 2023. Molecular evidence for olfactory neuroblastoma as a tumor of malignant globose basal cells. Mod Pathol. Feb 2;36(5):100122.gnant globose basal cells. Mod Pathol. Feb 2;36(5):100122. Abstract

2022

Ahlstedt BA, Ganji R, Raman M. The functional importance of VCP to maintaining cellular protein homeostasis. Biochem Soc Trans. Oct 5:BST20220648. doi: 10.1042/BST20220648. Abstract

Ameroso D, Meng A, Chen S, Felsted J, Dulla CG, Rios M. 2022. Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis. Nat Metab. May 2. doi: 10.1038/s42255-022-00566-0. Abstract

Armbruster M, Naskar S, Garcia JP, Sommer M, Kim E, Adam Y, Haydon PG, Boyden ES, Cohen AE, Dulla CG. 2022. Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes. Nat Neurosci. Apr 28. doi: 10.1038/s41593-022-01049-x. Abstract

Arora UP, Dumont BL. 2022. Meiotic drive in house mice: mechanisms, consequences, and insights for human biology. Chromosome Res. Jul 13. doi: 10.1007/s10577-022-09697-2. Abstract

Bayer AL, Pietruska J, Farrell J, McRee S, Alcaide P, Hinds PW. 2022. AKT1 is required for a complete palbociclib-induced senescence phenotype in BRAF-V600E-driven human melanoma. Cancers. Jan 23;14(3):572. doi: 10.3390/cancers14030572. Abstract

Brown RE, Su XA, Fair S, Wu K, Verra L, Jong R, Andrykovich K, Freudenreich CH. 2022. The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions. PLoS Biol. 27;20(12):e3001940. doi: 10.1371/journal.pbio.3001940. Abstract

Burn A, Roy F, Freeman M, Coffin JM. 2022. Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues. PLoS Biol. Oct 18;20(10):e3001826. doi: 10.1371/journal.pbio.3001826. Abstract

Byers C, Spruce C, Fortin HJ, Hartig EI, Czechanski A, Munger SC, Reinholdt LG, Skelly DA, Baker CL. 2022. Genetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cells. EMBO J. Dec 21:e109445. doi: 10.15252/embj.2021109445. Abstract

Foley KE, Hewes AA, Garceau DT, Kotredes KP, Carter GW, Sasner M, Howell GR. 2022. The APOEε3/ε4 genotype drives distinct gene signatures in the cortex of young mice. Front Aging Neurosci. Mar 16;14:838436. doi: 10.3389/fnagi.2022.838436. Abstract

Camarda N, Travers R, Yang VK, London C, Jaffe IZ. 2022. VEGF receptor inhibitor-induced hypertension: emerging mechanisms and clinical implications. Curr Oncol Rep. Feb 18. doi: 10.1007/s11912-022-01224-0. Abstract

Davis-Knowlton J, Turner JE, Harrington A, Liaw L. 2022. Smooth muscle cell Notch2 is not required for atherosclerotic plaque formation in ApoE null mice. J Vasc Res. Jul 7:1-14. doi: 10.1159/000525258. Abstract

Fatherree JP, Guarin JR, McGinn RA, Naber SP, Oudin MJ. 2022. Chemotherapy-induced collagen IV drives cancer cell motility through activation of Src and focal adhesion kinase. Cancer Res. Mar 8:canres.1823.2021. doi: 10.1158/0008-5472.CAN-21-1823. Abstract

Foley KE, Diemler CA, Hewes AA, Garceau DT, Sasner M, Howell GR. 2022. APOE ε4 and exercise interact in a sex-specific manner to modulate dementia risk factors. Alzheimers Dement. Jun 29;8(1):e12308. doi: 10.1002/trc2.12308. Abstract

Gaun V, Martens JR, Schwob JE. 2022. Lifespan of mature olfactory sensory neurons varies with location in the mouse olfactory epithelium and age of the animal. J Comp Neurol. Apr 17. doi: 10.1002/cne.25330. Abstract

Guarin JR, Fatherree JP, Oudin MJ. 2022. Chemotherapy treatment induces pro-invasive changes in liver ECM composition. Matrix Biol. 44: 1161-1171.  doi: 10.1016/j.matbio.2022.08.002. Abstract

Heller-Trulli D, Liu H, Mukherjee S, Moore CL.2022. UBE3D regulates mRNA 3'-end processing and maintains adipogenic potential in 3T3-L1 ells. Mol Cell Biol. Dec 15;42(12):e0017422. doi: 10.1128/mcb.00174-22. Abstract.

Hollander JM, Li L, Rawal M, Wang SK, Shu Y, Zhang M, Nielsen HC, Rosen CJ, Zeng L. 2022. A critical bioenergetic switch is regulated by IGF2 during murine cartilage development. Commun Biol. 5(1):1230. doi: 10.1038/s42003-022-04156-4. Abstract

Hui Mingalone CK, Nehme CR, Chen Y, Liu J, Longo BN, Garvey KD, Covello SM, Nielsen HC, James T, Messner WC, Zeng L. 2022. A novel whole "Joint-in-Motion" device reveals a permissive effect of high glucose levels and mechanical stress on joint destruction. Osteoarthritis Cartilage. S1063-4584(22)00914-1. doi: 10.1016/j.joca.2022.10.018. Abstract

Junier A, Weeks A, Alcaraz Y, Kumamoto CA. 2022. Bypass of Dfi1 regulation of Candida albicans invasive filamentation by iron limitation. mSphere. Feb 2:e0077921. doi: 10.1128/msphere.00779-21. Abstract

Liou YH, Personnaz J, Jacobi D, Knudsen NH, Chalom MM, Starost KA, Nnah IC, Lee CH. 2022. Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis. JCI Insight. Feb 22;7(4):e150041.doi: 10.1172/jci.insight.150041. Abstract

Lipo E, Asrat S, Huo W, Sol A, Fraser CS, Isberg RR. 2022. 5' untranslated mRNA regions allow bypass of host cell translation inhibition by Legionella pneumophila. Infect Immun. Nov 2:e0017922. doi: 10.1128/iai.00179-22. Abstract

Liu H, Heller-Trulli D, Moore CL. 2022. Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal. iScience. 2022 Jul 20;25(8):104804. doi: 10.1016/j.isci.2022.104804. Abstract

Malin J, Rosa Birriel C, Astigarraga S, Treisman JE, Hatini V. 2022. Sidekick dynamically rebalances contractile and protrusive forces to control tissue morphogenesis. J Cell Biol. 221(5):e202107035. doi: 10.1083/jcb.202107035. Abstract

Mithila F, Schwake C, Fang C, Merrill-Skoloff G, Covic L, Fritz DI, Hanada T, Flaumenhaft R, Chishti AH. 2022. Calpain-1 inhibition attenuates in vivo thrombosis in a humanized model of sickle cell disease. Thromb Res. Feb 4;211:123-126. doi: 10.1016/j.thromres.2022.01.029. Abstract

Nishijima H, Zunitch MJ, Yoshida M, Kondo K, Yamasoba T, Schwob JE, Holbrook EH. 2022. Rapid fluorescent vital imaging of olfactory epithelium. iScience. Apr 8;25(5):104222. doi: 10.1016/j.isci.2022.104222. Abstract

Porter EC, Stoppel WL, Kudej RK, Black LD 3rd. 2022. Right ventricular outflow tract surgical resection in young, large animal model for the study of alternative cardiovascular patches. Methods Mol Bio. 2485:299-309. doi: 10.1007/978-1-0716-2261-2_20. Abstract

Reagan AM, Onos KD, Heuer SE, Sasner M, Howell GR. 2022. Improving mouse models for the study of Alzheimer's disease. Curr Top Dev Biol. 2022;148:79-113. doi: 10.1016/bs.ctdb.2021.12.005. Abstract

SanMiguel JM, Eudy E, Loberg MA, Young KA, Mistry JJ, Mujica KD, Schwartz LS, Stearns TM, Challen GA, Trowbridge JJ.. 2022. Distinct tumor necrosis factor alpha receptors dictate stem cell fitness versus lineage output in Dnmt3a-mutant clonal hematopoiesis. Cancer Discov. Dec 2;12(12):2763-2773. doi: 10.1158/2159-8290.CD-22-0086. Abstract

Schwake C, McKay L, Griffiths A, Scartelli C, Flaumenhaft R, Chishti AH. 2022. BDA-410 inhibits SARS-CoV-2 main protease activity and viral replication in mammalian cells. J Cell Mol Med. Sep 9. doi: 10.1111/jcmm.17442. Abstract

Schwake C, Hyon M, Chishti AH. 2022. Signal peptide peptidase: A potential therapeutic target for parasitic and viral infections. Exp Opin Ther Targets. Mar 2. doi: 10.1080/14728222.2022.2047932. Abstract

Shuey MM, Xiang RR, Moss ME, Carvajal BV, Wang Y, Camarda N, Fabbri D, Rahman P, Ramsey J, Stepanian A, Sebastiani P, Wells QS, Beckman JA, Jaffe IZ. 2022. Systems approach to integrating preclinical apolipoprotein E-knockout investigations reveals novel etiologic pathways and master atherosclerosis network in humans. Arterioscler Thromb Vasc Biol. 42: 35-48. Abstract

Su K, Collins MP, McGuire CM, Alshagawi MA, Alamoudi MK, Li Z, Forgac M. 2022. Isoform a4 of the vacuolar ATPase a subunit promotes 4T1-12B breast cancer cell-dependent tumor growth and metastasis in vivo. J Biol Chem. Aug 18:102395. doi: 10.1016/j.jbc.2022.102395. Abstract

Sunkavalli A, McClure R, Genco C. 2022. Molecular regulatory mechanisms drive emergent pathogenetic properties of Neisseria gonorrhoeae. Microorganisms. Apr 28;10(5):922. doi: 10.3390/microorganisms10050922. Abstract

Thorsen MK, Draganova EB, Heldwein EE. 2022. The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. PLoS Pathog. Jul 8;18(7):e1010623. doi: 10.1371/journal.ppat.1010623. Abstract

Wolter NL, Jaffe IZ. 2022. Emerging vascular cell-specific roles for mineralocorticoid receptor: implications for understanding sex differences in cardiovascular disease. Am J Physiol Cell Physiol. Nov 28. doi: 10.1152/ajpcell.00372.2022. Abstract

Yang H, Yuan L, Ibaragi S, Li S, Shapiro R, Vanli N, Goncalves KA, Yu W, Kishikawa H, Jiang Y, Hu AJ, Jay D, Cochran B, Holland EC, Hu GF. 2022. Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival. Brit J Cancer. Aug;127(3):422-435. doi: 10.1038/s41416-022-01814-6. Abstract

Yeo AT, Rawal S, Delcuze B, Christofides A, Atayde A, Strauss L, Balaj L, Rogers VA, Uhlmann EJ, Varma H, Carter BS, Boussiotis VA, Charest A. 2022. Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression. Nat Immunol. May 27. doi: 10.1038/s41590-022-01215-0.  Abstract

2021

Arora UP, Charlebois C, Lawal RA, Dumont BL. 2021. Population and subspecies diversity at mouse centromere satellites. BMC Genomics. 22(1):279. doi: 10.1186/s12864-021-07591-5. Abstract

Biwer LA, Carvajal BV, Lu Q, Man JJ, Jaffe IZ. 2021. Mineralocorticoid and estrogen receptors in endothelial cells coordinately regulate microvascular function in obese female mice. Hypertension. 77: 2117-2126. Abstract

Byers C, Spruce C, Fortin HJ, Hartig EI, Czechanski A, Munger SC, Reinholdt LG, Skelly DA, Baker CL. 2021. Genetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cells. EMBO J. Dec 21:e109445. doi: 10.15252/embj.2021109445. Abstract

Draganova EB, Thorsen MK, Heldwein EE. 2021. Nuclear egress. Curr Issues Mol Biol. 41: 125-170. Abstract

Eidell KP, Lovy A, Sylvain NR, Scangarello FA, Muendlein HI, Ophir MJ, Nguyen K, Seminario MC, Bunnell SC. 2021. LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors. J Cell Sci. 19:jcs.258602. doi: 10.1242/jcs.258602. Abstract

Forte E, McLellan MA, Skelly DA, Rosenthal NA. 2021. Ex uno, plures - From one tissue to many cells: A review of single-cell transcriptomics in cardiovascular biology. Int J Mol Sci. 22: 2071. Abstract

Garcia JP, Dulla CG. 2021. Oops!...Glutamate did it again. Epilepsy Curr. Oct 30;22(1):61-63. doi: 10.1177/15357597211055287. Abstract

Goodwill AG, Baker HE, Dick GM, McCallinhart PE, Bailey CA, Brown SM, Man JJ, Tharp DL, Clark HE, Blaettner BS, Jaffe IZ, Bowles DK, Trask AJ, Tune JD, Bender SB. 2021. Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in Kv channels. Basic Res Cardiol. 116(1):35. doi: 10.1007/s00395-021-00879-3. Abstract

Hasan N, Zhang Y, Georgakoudi I, Sonnenschein C, Soto AM. 2021. Matrix composition modulates vitamin D3's effects on 3D collagen fiber organization by MCF10A cells. Tissue Eng Part A. 27: 1399-1410. Abstract

Hilterbrand AT, Daly RE, Heldwein EE. 2021. Contributions of the four essential entry glycoproteins to HSV-1 tropism and the selection of entry routes. mBio. 12(2):e00143-21. doi: 10.1128/mBio.00143-21. Abstract

Hyde M, Bagley J, Hinds PW, Tsichlis P, Iacomini J. 2021. Hyperlipidemia induced metabolic changes in regulatory T cells result in altered function. Eur J Immunol. 51: 2577-2589. Abstract

Kim SK, Biwer LA, Moss ME, Man JJ, Aronovitz MJ, Martin GL, Carrillo-Salinas FJ, Salvador AM, Alcaide P, Jaffe IZ. 2021. Mineralocorticoid receptor in smooth muscle contributes to pressure overload-induced heart failure. Circ Heart Fail. 14(2):e007279. doi: 10.1161/CIRCHEARTFAILURE.120.007279. Abstract

Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR. Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H. Front Aging Neurosci. Oct 11;13:735524. doi: 10.3389/fnagi.2021.735524. Abstract

Lawal RA, Arora UP, Dumont BL. 2021. Selection shapes the landscape of functional variation in wild house mice. BMC Biol. Nov 19;19(1):239. doi: 10.1186/s12915-021-01165-3. Abstract

Man JJ, Lu Q, Elizabeth Moss M, Carvajal B, Baur W, Garza AE, Freeman R, Anastasiou M, Ngwenyama N, Adler GK, Alcaide P, Jaffe IZ. 2021. Myeloid mineralocorticoid receptor transcriptionally regulates P-Selectin glycoprotein ligand-1 and promotes monocyte trafficking and atherosclerosis. Arterioscler Thromb Vasc Biol. 41: 2740-2755. Abstract

Menon DP, Qi G, Kim SK, Moss ME, Penumatsa KC, Warburton RR, Toksoz D, Wilson J, Hill NS, Jaffe IZ, Preston IR. 2021. Vascular cell-specific roles of mineralocorticoid receptors in pulmonary hypertension. Pulm Circ. Jun 18;11(3):20458940211025240. doi: 10.1177/20458940211025240. Abstract

Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. 2021. ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nat Commun. 12(1):86. doi: 10.1038/s41467-020-20357-z. Abstract

Murray LP, Govindan R, Mora AC, Munro JB, Mace CR. 2021. Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance. Anal Bioanal Chem. 413: 3695-3706. Abstract

Neil AJ, Hisey JA, Quasem I, McGinty RJ, Hitczenko M, Khristich AN, Mirkin SM. 2021. Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging. Proc Natl Acad Sci USA 118(5):e2013080118. doi: 10.1073/pnas.2013080118. Abstract

Nevola KT, Kiel DP, Zullo AR, Weiss S, Homuth G, Foessl I, Obermayer-Pietsch B, Motyl KJ, Lary CW. 2021. miRNA Mechanisms Underlying the association of beta blocker use and bone mineral density. J Bone Miner Res. 36: 110-112. Abstract

Pace JR, Lampkin BJ, Abakah C, Moyer A, Miao J, Deprey K, Cerulli RA, Lin YS, Baleja JD, Baker D, Kritzer JA. 2021. Stapled β-hairpins featuring 4-mercaptoproline. J Am Chem Soc. 143: 15039-15044. Abstract

Papadopoulos G, Berland R, Sunkavalli A, Coats SR, Darveau RP, Genco CA. 2021. Microbial lipid A remodeling controls cross-presentation efficiency and CD8 T cell priming by modulating dendritic cell function. Infect Immun. 89: e00335-20. doi: 10.1128/IAI.00335-20. Abstract

Park L, Luth ES, Jones K, Hofer J, Nguyen I, Watters KE, Juo P. 2021. The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans. PLoS One 16(2):e0245587. doi: 10.1371/journal.pone.0245587. Abstract

Polinski JM, Zimin AV, Clark KF, Kohn AB, Sadowski N, Timp W, Ptitsyn A, Khanna P, Romanova DY, Williams P, Greenwood SJ, Moroz LL, Walt DR, Bodnar AG. 2021. The American lobster genome reveals insights on longevity, neural, and immune adaptations. Sci Adv. 7(26):eabe8290. doi: 10.1126/sciadv.abe8290. Abstract

Siokas I, Zhang D, Poltorak A, Muendlein H, Degterev A. 2021. Immunoprecipitation strategies to isolate RIPK1/RIPK3 complexes in mouse macrophages. Curr Protoc. Jun;1(6):e156. doi: 10.1002/cpz1.156. Abstract

Smith A, Watkins T, Theocharidis G, Lang I, Leschinsky M, Maione A, Kashpur O, Raimondo T, Rahmani S, Baskin J, Mooney DJ, Veves A, Garlick J. 2021. A novel 3D skin disease model to assess macrophage function in diabetes.Tissue Eng Part C Methods. 27: 49058 Abstract

Swanzey E, O'Connor C, Reinholdt LG. 2021. Mouse genetic reference populations: Cellular platforms for integrative systems genetics. Trends Genet. 2021 Mar;37(3):251-265. Abstract

Thorsen MK, Lai A, Lee MW, Hoogerheide DP, Wong GCL, Freed JH, Heldwein EE. 2021. Highly basic clusters in the herpes simplex virus 1 nuclear egress complex drive membrane budding by inducing lipid ordering. mBio. 12:e0154821. doi: 10.1128/mBio.01548-21. Abstract

Tolman NG, Balasubramanian R, Macalinao DG, Kearney AL, MacNicoll KH, Montgomery CL, de Vries WN, Jackson IJ, Cross SH, Kizhatil K, Nair KS, John SWM. 2021. Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice. Dis Model Mech. 2021 Feb 19;14(2):dmm046953. Abstract

Yeo AT, Jun HJ, Appleman VA, Zhang P, Varma H, Sarkaria JN, Charest A. 2021. EGFRvIII tumorigenicity requires PDGFRA co-signaling and reveals therapeutic vulnerabilities in glioblastoma. Oncogene. 40: 2682-2696.