Eri Anastas

My work focuses on epigenetic mechanisms involved in the control of gene expression and on the molecular processes involved in their regulation. The entry point for these studies is KDM2B, a histone H3K36me2/me1, H3K4me3 and perhaps H3K79me3/me2 demethylase. KDM2B regulates gene expression at multiple levels and its function is relevant to human cancer. In my work, I address molecular mechanisms involved in the regulation of KDM2B and in the functional role of KDM2B in the regulation of gene expression.