Supriya Agrawal

I am studying autophagy, the recycling of cell cytoplasmic constituents by way of isolation by autophagosome and fusion with a lysosome. It is a self-repair process that allows the cell to get rid of misfolded proteins, damaged organelles, and lipid droplets without resorting to cell death. In an adult human heart cardiac cells become quiescent and cease replicating, which means that dead cardiac cells cannot be replaced. Therefore, it is vital for myocardial cells to use autophagy to remain healthy and functioning. My study focuses on the role of autophagy in heart disease including hypertrophic cardiomyopathy (HCM) and cardiotoxicity due to chemotherapy.