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Graduate School of Biomedical Sciences

Sabrina Yen

PhD Student in Neuroscience
sabrina yen

Sabrina Yen

PhD Student in Neuroscience

Education: 
MD Student, National Yang-Ming University, Taipei, Taiwan
Research synopsis: 

Neuroactive steroids are endogenous agents in the brain that induce anaesthetic, anticonvulsant, anxiolytic, anti-depressive, and sedative effects by acting as positive allosteric mediators of, and by directly exerting metabotropic actions on, GABAA receptors (GABAARs). Imbalances in neuroactive steroid production result in neurological and psychiatric disorders, such as epilepsy, depression, schizophrenia, and anxiety. Membrane progesterone receptors (mPRs) have been shown to be a target of neuroactive steroids in mediating GABAARs, but their function in neuronal activity regulation have yet to be elucidated. With electrophysiology and behavioural assays, I am investigating the role that mPRs play in the distinct neuropharmacological mechanisms incited by neuroactive steroids.

Advisor: