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Graduate School of Biomedical Sciences

Machlan Sawden

PhD Student in Immunology
machlan sawden

Machlan Sawden

PhD Student in Immunology

Education: 
BS, Biology, Tufts University, Medford, MA
Research synopsis: 

Once thought to be entirely derived from bone-marrow monocytes, embryonically-seeded tissue-resident macrophages are a self-sustaining population of cells with specialized functions in tissue development, response to insult, and maintenance of homeostasis. However, many age-related diseases are associated with a shift in the tissue macrophage pool toward bone marrow-derived macrophages, which cannot fully replicate the specialized role of tissue-resident macrophages and contribute to chronic inflammation. My project seeks to understand the underlying mechanisms of tissue-resident macrophage maintenance and how it is dysregulated with age.

Advisor: