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Graduate School of Biomedical Sciences

Luke Parsley

PhD Student in Mammalian Genetics at JAX
luke parsley

Luke Parsley

PhD Student in Mammalian Genetics at JAX

Education: 
BA, Biochemistry & Molecular Biology, Rollins College, Orlando, FL
Research synopsis: 

My thesis focuses on the utilization of Massively Parallel Reporter Assays (MPRA) to profile cis-regulatory elements as they pertain to varied disease states. Many disease-associated variants in the human genome map to intergenic regions enriched for cis-regulatory elements. Complex diseases can be modified by these variants, which may cumulatively enable predisposition. I hope to understand how these variants can affect gene expression and to model spectra of variants in mice to clarify the role of cis-regulatory elements in modification of disease.

Advisor: