Salwa Mohd Mostafa
One of the post-transcriptional modifications of pre-mRNA is the cleavage and polyadenylation of the 3' end. Polyadenylation is important for the stability, localization and translation efficiency of the mRNA. Eukaryotic genes have multiple pA sites (alternative polyadenylation), which in turn can regulate the expression of these genes. Currently, I am studying the molecular mechanisms that lead to alternative polyadenylation.