Laura Moreno de Lara
HIV prevalence is increasing worldwide, with women from certain areas disproportionately affected by HIV infection. Although sexual intercourse is the main route of HIV acquisition in women, the transmission rate is low. This fact suggests a role for the local innate immune system in protection against HIV infection. Our laboratory previously reported that neutrophils can inactivate HIV in the genital mucosa by releasing neutrophil extracellular traps (NETs), consisting of extracellular DNA fibers coated with proteins.
My research is focused on identifying the mechanisms that mediate HIV recognition by genital neutrophils, the subsequent release of NETs, and the NET-associated protein composition that inactivates HIV.