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Graduate School of Biomedical Sciences

Yonkyu Jang

PhD Student in Biology

yonkyu jang

Yonkyu Jang

PhD Student in Biology

Education: 
BS, Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
Research synopsis: 

Difficult-to-repair DNA lesions, such as DNA persistent double strand breaks or collapsed replication forks, re-localize to the nuclear periphery in yeast cells. In a previous study, the Freudenreich lab showed that expanded CAG repeats also re-localize to the nuclear periphery, specifically the nuclear pore complex, and that this relocation prevents chromosome breakage (Su et al, 2015). Since expanded CAG repeats are known to form secondary DNA structures that cause fork stalling during replication, it was hypothesized that relocation facilitates fork restart. I am currently investigating the fork restart mechanism at expanded CAG repeats and the role of relocation to the nuclear pore complex.