Iris Jaffe, MD, PhD, Rotation Advisor
Treatment-induced cardiovascular disease remains the second leading cause of morbidity and mortality in the rapidly-growing population of long-term cancer survivors. My rotation project involves implementing a machine learning analysis to characterize how the phosphoproteome and epigenome of cancer and vascular cell lines are reprogrammed in response to a battery of chemotherapies and cardiovascular agents. Additionally, I have been working to recapitulate some of our findings in the phosphoproteomics dataset with western blots to demonstrate that we can interrogate hypotheses generated with in-silico techniques using experimental biology. Understanding how these two groups of cell lines respond to different therapy regimens could point to more effective prophylaxis and treatment options for patients with chemotherapy-induced vascular disease.