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Graduate School of Biomedical Sciences

Irina Smirnova

Research Associate
Irina Smirnova

Irina Smirnova

Research Associate

Education: 
BS, Chemistry, St Petersburg University, St Petersburg, Russia
PhD, Chemistry, Technological Institute, St Petersburg, Russia
Research synopsis: 

Toll-like receptor 4 (TLR4) is part of the mammalian endotoxin (LPS – lipopolysacharide) sensing complex and is an important gene because it detects the early stages of a bacterial infection.  In order to identify new genes that may be involved in innate immune response, we compared several inbred and wild-derived strains of mice in their response to various agonists of toll-like receptors (Tlr) family members. Genetic analysis of the backcross progeny showed that some of the phenotypes do not appear to be linked to any of Tlr loci in mouse genome, thus revealing new genes that might be involved in innate response.