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Graduate School of Biomedical Sciences

Najma Bhat

Research Associate
Najma Bhat

Najma Bhat

Research Associate

Education: 
BSc, Chemistry, Aligarh Muslim University, Aligarh, India
MSc, Biochemistry, Aligarh Muslim University, Aligarh, India
PhD, Biochemistry, Aligarh Muslim University, Aligarh, India
Research synopsis: 

Cryptosporidium sporozoite attachment to epithelial cells and subsequent invasion are crucial events in the establishment of an infection. My work focuses on the way carbohydrate-mediated interaction of sporozoites with host cells is mediated and on the enzymes involved in mucin-type O-glycosylation of the pathogen-encoded glycoproteins. I have cloned, expressed and characterized a Gal/GalNAc-specific lectin, Cp30 that binds to glycoconjugates on host cells as well as on the parasite and shown that Gal/GalNAc-containing molecules, especially mucins and mucin-like proteins on the host cell and sporozoite surface are involved in mediating attachment. In addition, I have cloned and partially characterized polypeptide N-acetyl galactosaminyl transferases and am determining their role in mucin-type O-glycosylation of Cryptosporium glycoproteins.

Advisor: