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Graduate School of Biomedical Sciences

Joshua Smalley

Postdoctoral Scholar

Joshua Smalley

Joshua Smalley

Postdoctoral Scholar

Education: 
BSc, Biochemistry, University of Surrey, Surrey, United Kingdom
MSc, Toxicology, University of Surrey, Surrey, United Kingdom
PhD, Genetics, University of Leicester, Leicester, United Kingdom
Research synopsis: 

γ-aminobutyric acid receptors (GABAARs) are Cl- -preferring ligand-gated ion channels that mediate fast (phasic) synaptic inhibition and tonic (sustained) inhibition in the adult brain. They are important drug targets for benzodiazepines, intravenous anesthetics, and neurosteroids. My research involves the isolation and characterization of endogenous GABAAR subunit composition, studying how this can influence receptor-interacting proteins, and how this dictates the pharmacology and sub-cellular localization of GABAAR sub-types. This work involves the development of large data-rich 'omic' technologies and bioinformatic analyses with the aim of discovering novel targets for neurological diseases.

Advisor: