Amy Yee
Professor of Developmental, Molecular & Chemical Biology

Education:
BS, Biochemistry, University of California, Berkeley
PhD, Biochemistry, University of California, Davis
Postdoctoral Training, The Rockefeller University
Links:
Research synopsis:
We are investigating new molecular mechanisms of tumor suppression to design new diagnostic and therapeutic strategies in breast cancer. We combine investigations in signaling pathways and in transcriptional regulation with directed clinical studies. We focus on the Wnt pathway, which has emerged as a major pathway in breast and other cancers, and HBP1, as a transcriptional repressor that is also a suppressor of Wnt signaling. HBP1 mutations are clinically associated with invasive breast cancer. Thus, HBP1 is a new tumor suppressor gene with clinical and molecular impact on invasive breast cancer.
Lab members:
Mariam Alamoudi, PhD Student in Pharmacology & Experimental Therapeutics
Sumaiah Alrubiaan, PhD Student in Pharmacology & Experimental Therapeutics
Ahlam Bogis, PhD Student in Pharmacology & Experimental Therapeutics
K Eric Paulson, Research Assistant Professor
Urvi Vani, MS Student in Pharmacology & Drug Development