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Graduate School of Biomedical Sciences

Recent Publications from the Xu Lab

Li Y, Jarvis R, Zhu K, Glass Z, Ogurlu R, Gao P, Li P, Chen J, Yu Y, Yang Y, Xu Q. 2020. Protein and mRNA delivery enabled by cholesteryl-based biodegradable lipidoid nanoparticles. Angew Chem Int Ed Engl. doi: 10.1002/anie.202004994. Abstract

Yang L, Ma F, Liu F, Chen J, Zhao X, Xu Q. 2020. Efficient delivery of antisense oligonucleotides using bioreducible lipid nanoparticles in vitro and in vivo. Mol Ther Nucleic Acids 19:1357-1367. Abstract

Li Y, Glass Z, Huang M, Chen ZY, Xu Q. 2020. Ex vivo cell-based CRISPR/Cas9 genome editing for therapeutic applications. Biomaterials 234:119711. doi: 10.1016/j.biomaterials.2019.119711. Abstract

Parker RN, Wu WA, McKay TB, Xu Q, Kaplan DL. 2019. Design of silk-elastin-like protein nanoparticle systems with mucoadhesive properties. J Funct Biomater. 10(4). pii: E49. doi: 10.3390/jfb10040049. Abstract

Li Y, Glass Z, Xu Q. 2018. Rescued from the fate of neurological disorder. Nat Biomed Eng. 2: 469-470.  Abstract

Chang J, Chen X, Glass Z, Gao F, Mao L, Wang M, Xu Q. 2018. Integrating combinatorial lipid nanoparticle and chemically modified protein for intracellular delivery and genome editing. Acc Chem Res. Epub ahead of print. Abstract

Li Y, Li AC, Xu Q. 2018. Intracellular delivery of His-tagged genome-editing proteins enabled by nitrilotriacetic acid-containing lipidoid nanoparticles. Adv Healthc Mater. Epub ahead of print. Abstract

Li Y, Bolinger J, Yu Y, Glass Z, Shi N, Yang L, Wang M, Xu Q. 2018. Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles. Biomater Sci. Epub ahead of print. Abstract

Glass Z, Lee M, Li Y, Xu Q. 2018. Engineering the Delivery System for CRISPR-based genome editing. Trends Biotechnol. Epub ahead of print. Abstract

Glass Z, Li Y, Xu Q. 2017. Nanoparticles for CRISPR-Cas9 delivery. Nat Biomed Eng. 1: 854-855. Abstract

Wang X, Li Y, Li Q, Neufeld CI, Pouli D, Sun S, Yang L, Deng P, Wang M, Georgakoudi I, Tang S, Xu Q. 2017. Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles. J Control Release Epub ahead of print.  Abstract

Wang M, Glass ZA, Xu Q. 2016. Non-viral delivery of genome-editing nucleases for gene therapy. Gene Ther. Epub ahead of print. Abstract

Altınoğlu SA, Wang M, Li KQ, Li Y, Xu Q. 2016. Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. Biomater Sci. Epub ahead of print.  Abstract

Wang M, Zuris JA, Meng F, Rees H, Sun S, Deng P, Han Y, Gao X, Pouli D, Wu Q, Georgakoudi I, Liu DR, Xu Q. 2016. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proc Natl Acad Sci USA Epub ahead of print.  Abstract

Alberti KA, Xu Q. 2016. Biocompatibility and degradation of tendon-derived scaffolds. Regen Biomater. 3: 1-11.  Abstract

Wang M, Altinoglu S, Takeda YS, Xu Q. 2015. Integrating protein engineering and bioorthogonal click conjugation for extracellular vesicle modulation and intracellular delivery. PLoS One 10: e0141860.  Abstract

Takeda YS, Xu Q. 2015. Neuronal differentiation of human mesenchymal stem cells using exosomes derived from differentiating neuronal cells. PLoS One 10: e0135111.  Abstract

Takeda YS, Xu Q. 2015. Synthetic and nature-derived lipid nanoparticles for neural regeneration. Neural Regen Res. 10: 689-690. Abstract

Alberti KA, Sun JY, Illeperuma WR, Suo Z, Xu Q. 2015. Laminar tendon composites with enhanced mechanical properties. J Mater Sci. 50: 2616-2625. Abstract

Wang M, Sun S, Neufeld CI, Perez-Ramirez B, Xu Q. 2014. Reactive oxygen species-responsive protein modification and its intracellular delivery for targeted cancer therapy. Angew Chem Int Ed Engl 53: 13444-13448. Abstract

Wang M, Alberti K, Varone A, Pouli D, Georgakoudi I, Xu Q. 2014. Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles. Adv Healthc Mater. 3: 1398-1403. Abstract

Wang M, Alberti K, Sun S, Arellano CL, Xu Q 2014. Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy. Angew Chem Int Ed Engl. 53: 2893-2898. Abstract

Alberti KA, Hopkins AM, Tang-Schomer MD, Kaplan DL, Xu Q. 2014. The behavior of neuronal cells on tendon-derived collagen sheets as potential substrates for nerve regeneration. Biomaterials 35: 3551-3557. Abstract

Alberti KA, Xu Q. 2012. Slicing, Stacking and Rolling: Fabrication of nanostructured collagen constructs from tendon sections. Adv Healthcare Mater. 2: 817-821. Abstract

Wang M, Sun S, Alberti KA, Xu Q. 2012. A combinatorial library of unsaturated lipidoids for efficient intracellular gene delivery. ACS Synth Biol.  1: 403–407. 

Sun S, Wang M, Knupp SA, Soto-Feliciano Y, Hu X, Kaplan DL, Anderson DG, Langer R,  Xu Q 2012. Combinatorial library of lipidoids for in vitro DNA delivery. Bioconjug Chem. 23: 135–140. Abstract

Dai X, Knupp S, Xu Q. 2012. Patterning nanoparticles in 3D matrix using electric-field assisted gel transferring technique (EFAGT). Langmuir 28: 2960-2964. Abstract

Sant S, Tao S, Fisher O, Xu Q, Peppas NA, Khademhosseini A. 2012. Microfabrication technologies for oral drug delivery. Adv Drug Del Rev. 64: 496–507. Abstract

Dai X, Schalek R, Xu Q. 2012 Staining-and-etching: a simple method to fabricate inorganic nanostructures from tissue slices. Adv Mater. 24: 370-374. Abstract