My research focuses on chronic kidney disease (CKD). My primary focus has been on the interplay among CKD, vascular disease including stroke and cardiovascular disease, and physical and cognitive function. I have experience as a clinical trialist, evaluating the effects of exercise in people with CKD and evaluating blood pressure targets in people with and without kidney disease. Consistent with my clinical emphasis on dialysis patient care, I work closely with collaborators at Dialysis Clinic, Inc (DCI) to leverage existing clinical data and natural experiments to inform clinical practice. These works have included evaluation of anemia management strategies, focusing on the effects of ‘epoetin stop’ policies, fluid management, vascular access, and nutritional support during dialysis, resulting in several landmark dialysis epidemiology publications. Lastly, in collaboration with investigators at Boston University, I am a member of a team investigating the epidemic of chronic kidney disease in Nicaragua that disproportionately affects young men of working age.