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Graduate School of Biomedical Sciences

Recent Publications from the Taylor Lab

Rowan S, Jiang S, Chang ML, Volkin J, Cassalman C, Smith KM, Streeter MD, Spiegel DA, Moreira-Neto C, Rabbani N, Thornalley PJ, Smith DE, Waheed NK, Taylor A. 2020. A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration. Free Radic Biol Med. pii: S0891-5849(19)32165-3. doi: 10.1016/j.freeradbiomed.2020.02.010. Abstract

Taylor A. 2019. On Isomerization as the secret Achilles' heel of long-lived proteins. J Biol Chem 29: 9689. Abstract

Bejarano E, Taylor A. 2019. Too sweet: Problems of protein glycation in the eye. Exp Eye Res. 178: 255-262. Abstract

Whitcomb EA, Tsai YC, Basappa J, Liu K, Le Feuvre AK, Weissman AM, Taylor A. 2019. Stabilization of p27Kip1/CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell-cycle control. FASEB J. 33: 1235-1247 Abstract

Rowan S, Bejarano E, Taylor A. 2018. Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochim Biophys Acta Mol Basis Dis. 1864: 3631-3643. Abstract

Chiu CJ, Rabbani N, Rowan S, Chang ML, Sawyer S, Hu FB, Willett W, Thornalley PJ, Anwar A, Bar L, Kang JH, Taylor A. 2018. Studies of advanced glycation end products and oxidation biomarkers for type 2 diabetes. Biofactors 44: 281-288. Abstract

Rowan S, Taylor A. 2018. The role of microbiota in retinal disease. Adv Exp Med Biol. 1074: 429-435. Abstract

Rowan S, Taylor A. 2018. Gut microbiota modify risk for dietary glycemia-induced age-related macular degeneration. Gut Microbes 9: 452-457. Abstract

Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A. 2017. Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration. Proc Natl Acad Sci USA 114: E4472-E4481. Abstract

Chiu CJ, Chang ML, Li T, Gensler G, Taylor A. 2017. Visualization of dietary patterns and their associations with age-related macular degeneration. Invest Ophthalmol Vis Sci. 58: 1404-1410. Abstract

Chiu CJ, Chang ML, Taylor A. 2016. Associations between periodontal microbiota and death rates. Sci Rep. 6:35428. Abstract

Rowan S, Chang ML, Reznikov N, Taylor A. 2016. Disassembly of the lens fiber cell nucleus to create a clear lens: the p27 descent. Exp Eye Res. pii: S0014-4835(16)30028-8. Abstract

Lyu L, Whitcomb EA, Jiang S, Chang ML, Gu Y, Duncan MK, Cvekl A, Wang WL, Limi S, Reneker LW, Shang F, Du L, Taylor A. 2015. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation leading to cataract. FASEB J 30: 1087-1095. Abstract

Rowan S, Taylor A. 2015. Gene-diet interactions in age-related macular degeneration. Adv Exp Biol. 854: 95-101. Abstract

Whitcomb EA, Chiu CJ, Taylor A 2015. Dietary glycemia as a determinant of health and longevity. Mol Aspects Med. 46: 14-20.  Abstract

Liu K, Lyu L, Chin D, Gao J, Sun X, Shang F, Caceres A, Chang ML, Rowan S, Peng J, Mathias R, Kasahara H, Jian S, Taylor A. 2015. Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract. Proc Natl Acad. Sci USA 112: 1071-1076.  Abstract

Chaffee BR, Shang F, Chang ML, Clement TM, Eddy EM, Wagner BD, Nakahara M, Nagata S, Robinson ML, Taylor A. 2014. Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development 141: 3388-3398. Abstract

Chiu CJ, Chang ML, Zhang FF, Li T, Gensler G, Schleicher M, Taylor A. 2014. The relationship of major American dietary patterns to age-related macular degeneration. Am J Ophthalmol. 158: 118-127. Abstract

Liu Z, Qin T, Zhou J, Taylor A, Sparrow JR, Shang F. 2014. Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genes. Adv Exp Med Biol. 801: 237-250. Abstract

Chang ML, Chiu CJ, Shang F, Taylor A. 2014. High glucose activates ChREBP-mediated HIF-1α and VEGF expression in human RPE cells under normoxia. Adv Exp Med Biol. 801: 609-621. Abstract

Rowan S, Weikel KA, Chang ML, Nagel BA, Thinschmidt J, Carey AN, Grant MB, Fliesler SJ, Smith D, Taylor A. 2014. Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice. Invest Ophthalmol Vis Sci. 55: 492-501. Abstract

Whitcomb EA, Shang F, Taylor A. 2013. Common cell biologic and biochemical changes in aging and age-related diseases of the eye: toward new therapeutic approaches to age-related ocular diseases. Invest Ophthalmol Vis Sci. 54: ORSF31-36. Abstract

Weikel KA, Garber C, Baburins A, Taylor A. 2013. Nutritional modulation of cataract. Nutr Rev. 72: 30-47. Abstract

Schleicher M, Weikel K, Garber C, Taylor A. 2013. Diminishing risk for age-related macular degeneration with nutrition: a current view. Nutrients 5:2405-2456.  Abstract