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Graduate School of Biomedical Sciences

Miguel Stadecker

Professor of Immunology
Miguel Stadecker

Miguel Stadecker

Professor of Immunology

Office phone: 617-636-6732
Lab phone: 617-636-2979
Campus: Boston
Office: Jaharis 501J
Laboratory: 
Jaharis 501
Education: 
BA, National School Nr. 8, Buenos Aires
MD, University of Buenos Aires School of Medicine
PhD, Immunology, Tufts University
Postdoctoral Training, Harvard University
Research synopsis: 

I maintain an active research program, but no longer accept PhD thesis students. I participate fully in program activities through teaching and mentoring.

My laboratory studies schistosomiasis, a disease caused by parasitic helminths of the genus Schistosoma, suffered by more than 200 million people throughout the world. The main pathology in schistosomiasis is a host CD4 T lymphocyte-mediated granulomatous inflammation against parasite eggs, which in the case of the species Schistosoma mansoni, takes place in the liver and intestines. Disease severity varies considerably, both in the human patient population, as well as among mouse strains in an experimental murine model. Our goal is to understand the role and interplay of CD4 T cell subpopulations in shaping the immunopathology in schistosomiasis, with emphasis on Th17 cells that mediate a severe form of disease. Current emphasis is placed on understanding the mechanism by which dendritic cell C-type lectin receptors sensing parasite eggs, can stimulate the secretion of proinflammatory cytokines that promote the development of pathogenic Th17 cells.

Lab members: