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Graduate School of Biomedical Sciences

Recent Publications from the Soto & Sonnenschein Lab

Montévil M, Acevedo N, Schaeberle CM, Bharadwaj M, Fenton SE, Soto AM. 2020. A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study. Environ Health Perspect. 128(5):57001. doi: 10.1289/EHP6301. Abstract

Sonnenschein C, Soto AM. 2020. Over a century of cancer research: Inconvenient truths and promising leads. PLoS Biol. 18: e3000670. Abstract

Bich L, Mossio M, Soto AM. 2020. Glycemia regulation: From feedback loops to organizational closure. Front Physiol. 11:69. doi: 10.3389/fphys.2020.00069. eCollection 2020. Abstract

Hasan N, Sonnenschein C, Soto AM. 2019. Vitamin D3 constrains estrogen's effects and influences mammary epithelial organization in 3D cultures. Sci Rep. 9: 7423. Abstract

Rubin BS, Schaeberle CM, Soto AM. 2019. The case for BPA as an obesogen: Contributors to the controversy. Front Endocrinol. 10:30. Abstract

Liu Z, Speroni L, Quinn KP, Alonzo C, Pouli D, Zhang Y, Stuntz E, Sonnenschein C, Soto AM, Georgakoudi I. 2018. 3D organizational mapping of collagen fibers elucidates matrix remodeling in a hormone-sensitive 3D breast tissue model. Biomaterials 179: 96-108. Abstract

Acevedo N, Rubin BS, Schaeberle CM, Soto AM. 2018. Perinatal BPA exposure and reproductive axis function in CD-1 mice. Reprod Toxicol. 79: 39-46. Abstract

Soto AM, Sonnenschein C. 2018. Endocrine disruptors - putting the mechanistic cart before the phenomenological horse. Nat Rev Endocrinol. Epub ahead of print. Abstract

Sweeney MF, Sonnenschein C, Soto AM. 2018. Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D. Cancer Cell Int. 18: 43. Abstract

Sonnenschein C, Soto AM. 2017. An Integrative approach toward biology, organisms, and cancer. Methods Mol Biol 1702: 15-26. Abstract

Soto AM, Schaeberle C, Maier MS, Sonnenschein C, Maffini MV. 2017. Evidence of absence: Estrogenicity assessment of a new food-contact coating and the bisphenol used in its synthesis. Environ Sci Technol. 51: 1718-1726.  Abstract

Speroni L, Voutilainen M, Mikkola ML, Klager SA, Schaeberle CM, Sonnenschein C, Soto AM. 2017. New insights into fetal mammary gland morphogenesis: differential effects of natural and environmental estrogens. Sci Rep. 7: 40806. Abstract

Soto AM, Longo G, Noble D. 2016. Preface to "From the century of the genome to the century of the organism: New theoretical approaches". Prog Biophys Mol Biol. 122: 1-3.  Abstract

Montévil M, Speroni L, Sonnenschein C, Soto AM. 2016. Modeling mammary organogenesis from biological first principles: Cells and their physical constraints. Prog Biophys Mol Biol. 122: 58-69. Abstract

Sonnenschein C, Soto A. 2016. Carcinogenesis explained within the context of a theory of organisms. Prog Biophys Mol Biol. 122:70-76. Abstract

Soto AM, Longo G, Miquel PA, Montevil M, Mossio M, Perret N, Pocheville A, Sonnenschein C. 2016. Toward a theory of organisms: Three founding principles in search of a useful integration. Prog Biophys Mol Biol. Epub ahead of print. Abstract

Schug TT, Johnson AF, Birnbaum LS, Colborn T, Guillette LJ Jr, Crews DP, Collins T, Soto AM, Vom Saal FS, McLachlan JA, Sonnenschein C, Heindel JJ. 2016. Minireview: Endocrine disruptors: Past lessons and future directions. Mol Endocrinol. 30: 833-847. Abstract

Soto AM, Longo G, Montévil M, Sonnenschein C. 2016. The biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms. Prog Biophys Mol Biol. Epub ahead of print. Abstract

Longo G, Soto AM. 2016. Why do we need theories? Prog Biophys Mol Biol. Epub ahead of print. Abstract

Zalko D, Soto AM, Canlet C, Tremblay-Franco M, Jourdan F, Cabaton NJ. 2016. Bisphenol A exposure disrupts neurotransmitters through modulation of transaminase activity in the brain of rodents. Endocrinology 157: 1736-1739. Abstract

Paulose T, Montévil M, Speroni L, Cerruti F, Sonnenschein C, Soto AM. 2016. SAMA: A method for 3D morphological analysis. PLoS One 11: e0153022. Abstract

Speroni L, Sweeney MF, Sonnenschein C, Soto AM. 2016. A hormone-responsive 3D culture model of the human mammary gland epithelium. J Vis Exp. Feb 7 (108). Abstract

Sweeney MF, Hasan N, Soto AM, Sonnenschein C. 2016. Environmental endocrine disruptors: Effects on the human male reproductive system. Rev Endocr Metab Disord. 16: 341-357. Abstract

Sonnenschein C, Soto AM. 2015. Cancer metastases: So close and so far. J Natl Cancer Inst. 107.   Abstract

Soto AM, Sonnenschein C. 2015. Endocrine disruptors: DDT, endocrine disruption and breast cancer. Nat Rev Endocrinol. 11: 507-508.   Abstract

Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto AM, Georgakoudi I. 2015. Rapid three-dimensional quantification of voxel-wise collagen fiber orientation. Biomed Opt Express 6: 2294-2310.  Abstract

Sonnenschein C, Davis B, Soto AM. 2014. A novel pathogenic classification of cancers. Cell Cancer Int. 14: 113. Abstract

Paulose T, Speroni L, Sonnenschein C, Soto AM. 2014. Estrogens in the wrong place at the wrong time: Fetal BPA exposure and mammary cancer. Reprod Toxicol. 54: 58-65. Abstract

Dhimolea E, Wadia PR, Murray TJ, Settles ML, Treitman JD, Sonnenschein C, Shioda T, Soto AM. 2014. Prenatal dxposure to BPA alters the epigenome of the rat mammary gland and increases the propensity to neoplastic development. PLoS One 9: e99800. Abstract

Sonnenschein C, Soto AM. 2014. Cancer and the elusive cancer genes. Med Sci (Paris) 30: 688-692. Abstract

Barnes C, Speroni L, Quinn KP, Montevil M, Saetzler K, Bode-Animashaun G, McKerr G, Georgakoudi I, Downes CS, Sonnenschein C, Howard CV, Soto AM. 2014. From single cells to tissues: Interactions between the matrix and human breast cells in real time. PLoS One 9: e93325. Abstract

Sonnenschein C, Soto AM. Rangarajan A, Kulkarni P. 2014. Competing views on cancer. J Biosci. 39: 1-22.   Abstract

Soto AM, Sonnenschein C 2014. One hundred years of somatic mutation theory of carcinogenesis: Is it time to switch? Bioessays 36:118-120. Abstract

Speroni L, Whitt GS, Xylas J, Quinn KP, Jondeau-Cabaton A, Barnes C, Georgakoudi I, Sonnenschein C, Soto AM. 2014. Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model. Tissue Eng Part C Methods 20: 42-51. Abstract