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Graduate School of Biomedical Sciences

Recent Publications from the Sharma Lab

Anastasiou M, Newton GA, Kaur K, Carrillo-Salinas FJ, Smolgovsky SA, Bayer AL, Ilyukha V, Sharma S, Poltorak A, Luscinskas FW, Alcaide P. 2021. Endothelial STING controls T cell transmigration in an IFN-I dependent manner. JCI Insight. 22:149346. doi: 10.1172/jci.insight.149346. Abstract

Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. 2018. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. Epub ahead of print. Abstract

Orlowski GM, Sharma S, Colbert JD, Bogyo M, Robertson SA, Kataoka H, Chan FK, Rock KL. 2017. Frontline Science: Multiple cathepsins promote inflammasome independent, particle-induced cell death during NLRP3 dependent IL-1b activation. J Leukoc Biol. 102: 7-17. Abstract

Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. 2017. Taking the STING out of TLR-driven autoimmune diseases - Good, bad, or indifferent? J Leukoc Biol. 101: 121-126. Abstract

Baum R, Sharma S, Organ JM, Burr DB, Hornung V, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM. 2017. STING contributes to abnormal bone formation induced by deficiency of DNase II in mice. Arthritis Rheumatol. 69: 460-471. Abstract

Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. 2016.Synergy between hematopoietic and radioresistant stromal cells is required for autoimmune manifestations of DNase II-/-IFNaR-/- mice. J Immunol 196: 1348-1354. Abstract

Surpris G, Chan J, Thompson M, Ilyukha V, Liu BC, Atianand M, Sharma S, Volkova T, Smirnova I, Fitzgerald KA, Poltorak A. 2016. Cutting Edge: Novel Tmem173 allele reveals importance of STING N terminus in trafficking and type I IFN production. J Immunol. 196: 547-552. Abstract

Orlowski GM, Colbert JD, Sharma S, Bogyo M, Robertson SA, Rock KL. 2015. Multiple cathepsins promote pro-IL-1β synthesis and NLRP3-mediated IL-1β activation. J Immunol. 195: 1685-1697. Abstract

Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. 2015. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 33: S70-S73. Abstract

Sharma S, Fitzgerald KA, Cancro MP, Marshak-Rothstein A. 2015. Nucleic acid-sensing receptors: Rheostats of autoimmunity and autoinflammation. J Immunol. 195: 3507-3512. Abstract

Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. 2015. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci USA 112: E710-E717. Abstract

Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM. 2015. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol. 194: 873-877. Abstract

Thompson MR, Sharma S, Atianand M, Jensen SB, Carpenter S, Knipe DM, Fitzgerald KA, Kurt-Jones EA. 2014. Interferon γ-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses. J Biol Chem. 289: 23568-235681. Abstract

Gupta R, Ghosh S, Monks B, DeOliveira RB, Tzeng TC, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock DT. 2014. RNA and β-hemolysin of group B Streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem. 389: 13701-13705. Abstract