My lab focuses on the innate immune response to nucleic acids from microbial sources as well as from ourselves. Specifically, we are evaluating the role of pathways that sense nucleic acids to shape host metabolism, tissue remodeling, fibrosis and wound healing responses. A particular focus of the lab is to understand the contribution of intracellular DNA sensing to immune-homeostasis. Using a combination of hypothesis driven and unbiased next gen approaches we hope to clarify the signaling nodes engaged during homeostasis. The physiological impact of the pathways we discover will be tested in models of inflammation including infections, autoimmunity, aging and neurodegenerative diseases. These studies will directly impact our understanding of resolution of inflammation in all settings.
A post-doc position is available in the Sharma lab to study the impact of innate immune sensing of nucleic acids on maintaining the epigenetic states of inflammation. We are interested in understanding the mechanisms controlling gene expression and specific gene expression patterns following sensing of DNA and RNA. Models of disease that we specifically focus on are multi-system chronic inflammatory models. If you are interested in investigating novel gene expression programs during innate immune responses and have some training in Bioinformatics please email your CV to me.