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Graduate School of Biomedical Sciences

Alexander Poltorak

Professor and Interim Chair of Immunology
Alexander Poltorak

Alexander Poltorak

Professor and Interim Chair of Immunology

Office phone: 617-636-3596
Lab phone: 617-636-3945
Campus: Boston
Office: Jaharis 529A
Laboratory: 
Jaharis 527
Education: 
BS, Chemistry, St Petersburg University
PhD, Chemistry, Technological Institute
Postdoctoral Training, University of Texas Southwestern Medical Center
Research synopsis: 

We are interested in cell death and inflammatory responses as two critical components of the host immune defense against pathogens. We use forward genetic analysis in the wild-derived strains of mice to investigate regulatory mechanisms of cell death and inflammation. Our recent work has uncovered importance of constitutive (tonic) type I Interferon (IFN-I) in initiation of programed cell death such as pyroptosis and necroptosis. This constitutive IFN signature is induced by STING-mediated DNA-sensing pathway and maintains the expression of unknown effectors of necroptosis. We are currently focusing on identifying these effectors by means of forward genetic analysis.

Lab members: