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Graduate School of Biomedical Sciences

Alexander Poltorak

Professor of Immunology
Alexander Poltorak

Alexander Poltorak

Professor of Immunology

Office phone: 617-636-3596
Lab phone: 617-636-3945
Campus: Boston
Office: Jaharis 529A
Jaharis 527
BS, Chemistry, St Petersburg University
PhD, Chemistry, Technological Institute
Postdoctoral Training, University of Texas Southwestern Medical Center
Research synopsis: 

We are interested in cell death and inflammatory responses as two critical components of the host immune defense against pathogens. We use forward genetic analysis in the wild-derived strains of mice to investigate regulatory mechanisms of cell death and inflammation. Our recent work has uncovered importance of constitutive (tonic) type I Interferon (IFN-I) in initiation of programed cell death such as pyroptosis and necroptosis. This constitutive IFN signature is induced by STING-mediated DNA-sensing pathway and maintains the expression of unknown effectors of necroptosis. We are currently focusing on identifying these effectors by means of forward genetic analysis.

First year student rotation projects are available in the following areas: role of endocytosis in the immune response; TRIFosome - a new hub of the early immune response; mouse model of cytokine storm and septic shock; and cell death and inflammatory response as two branches of the host immune response.

Lab members: