One of the most fundamental questions in microbiology is to understand how bacteria sense, respond, and adapt to different environments. In addition to adjusting to the changes in the physical environments, bacterial pathogens also interact with other biological entities, including the host, other bacterial cells, and the viruses that attack them. My group employs a multidisciplinary approach to study Vibrio cholerae, the bacterium that causes million cases of diarrheal disease cholera worldwide, as a model to under the molecular mechanisms governing these interactions. We hope to harness our findings to develop novel therapeutics to combat infectious diseases.