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Graduate School of Biomedical Sciences

Sergei Mirkin

White Family Professor of Biology
Sergei Mirkin

Sergei Mirkin

White Family Professor of Biology

Office phone: 617-627-4794
Lab phone: 617-627-4828
Campus: Medford
Laboratory: 
200 Boston Ave, Ste 4742
Education: 
MS, Genetics, Moscow State University
PhD, Molecular Biology, Institute of Molecular Genetics, Moscow
Postdoctoral Training, Institute of Molecular Genetics, Moscow
Research synopsis: 

I study the mechanisms responsible for the instability of DNA repeats in various genomes. I am particularly interested in the mechanisms of expansions of triplet DNA repeats that cause numerous hereditary disorders in humans, including Fragile X mental retardation, Huntington's disease, myotonic dystrophy, and Friedreich's ataxia. My lab was the first to show that expansions could be due to the ability of these repeats to trick DNA replication into lengthening them. We are substantiating the replication model for repeat expansions in several experimental systems.

Lab members: