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Graduate School of Biomedical Sciences

Recent Publications from the Maguire Lab

Antonoudiou P, Colmers PLW, Walton NL, Weiss GL, Smith AC, Nguyen DP, Lewis M, Quirk MC, Barros L, Melon LC, Maguire JL. 2021. Allopregnanolone mediates affective switching through modulation of oscillatory states in the basolateral amygdala. Biol Psychiatry. Jul 27:S0006-3223(21)01470-0. doi: 10.1016/j.biopsych.2021.07.017. Abstract

Maguire J. 2021. Mechanisms of psychiatric comorbidities in epilepsy. Curr Top Behav Neurosci. Mar 16. doi: 10.1007/7854_2020_192. Abstract

Basu T, Maguire J, Salpekar JA. 2021. Hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy. Neurosci Lett. 8:135618. doi: 10.1016/j.neulet.2020.135618. Abstract

Sawant-Pokam PA, Vail TJ, Metcalf CS, Maguire JL, McKean TO, McKean NO, Brennan KC. 2020. Preventing neuronal edema increases network excitability after traumatic brain injury.J Clin Invest.130: 6005-6020. Abstract

Antonoudiou P, Maguire JL. 2020. How deep learning solved my seizure detection problems. Epilepsy Curr. 20:306-308.  Abstract

Ozawa M, Davis P, Ni J, Maguire J, Papouin T, Reijmers L. 2020. Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction. Nat Commun.11: 4358. doi: 10.1038/s41467-020-18199-w. Abstract

Christian CA, Reddy DS, Maguire J, Forcelli PA. 2020. Sex differences in the epilepsies and associated comorbidities: Implications for use and development of pharmacotherapies. Pharmacol Rev. 72: 767-800. Abstract

Maguire J, McCormack C, Mitchell A, Monk C. 2020. Neurobiology of maternal mental illness. Handb Clin Neurol. 171: 97-116. Abstract

Markey L, Hooper A, Melon LC, Baglot S, Hill MN, Maguire J, Kumamoto CA. 2020. Colonization with the commensal fungus Candida albicans perturbs the gut-brain axis through dysregulation of endocannabinoid signaling. Psychoneuroendocrinology 121: 104808. Abstract

Fagan MP, Ameroso D, Meng A, Rock A, Maguire J, Rios M. 2020. Essential and sex-specific effects of mGluR5 in ventromedial hypothalamus regulating estrogen signaling and glucose balance. Proc Natl Acad Sci USA 117: 19566-19577. Abstract

Colmers PLW, Maguire J. 2020. Network dysfunction in comorbid psychiatric illnesses and epilepsy. Epilepsy Curr. 20: 205-210. Abstract

Jin SX, Dickson D, Maguire J, Feig LA. 2020. Ras-GRF1 in CRF cells controls the early adolescent female response to repeated stress. J Endocrinol. 245: 397-410. Abstract

Maguire JL. 2020. Get with the (developmental) program. Epilepsy Curr. 20: 102-104. Abstract

Salpekar JA, Basu T, Thangaraj S, Maguire J. 2020. The intersections of stress, anxiety and epilepsy. Int Rev Neurobiol. 152: 195-219. Abstract

Maguire J. 2020. Mind the gate to improve comorbid cognitive impairments in epilepsy. Epilepsy Curr. 20: 61-63. Abstract

Mosher LJ, Cadeddu R, Yen S, Staudinger JL, Traccis F, Fowler SC, Maguire JL, Bortolato M. 2019. Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation. Psychoneuroendocrinology 108: 53-61. Abstract

Maguire J. 2019. What do we want? INHIBITION. When do we want it? NOW. Epilepsy Curr. 19: 402-404. Abstract

Maguire J. 2019. Fast-spiking interneurons exposed in tumor-associated epilepsy. Epilepsy Curr. 19: 119-121. Abstract

Walton N, Maguire J. 2019.  Allopregnanolone-based treatments for postpartum depression: Why/how do they work? Neurobiol Stress. 11: 100198. Abstract

Darnieder LM, Melón LC, Do T, Walton NL, Miczek KA, Maguire JL. 2019. Female-specific decreases in alcohol binge-like drinking resulting from GABAA receptor delta-subunit knockdown in the VTA. Sci Rep. 9: 8102. Abstract

Rincón-Cortés M, Herman JP, Lupien S, Maguire J, Shansky RM. 2019. Stress: Influence of sex, reproductive status and gender. Neurobiol Stress. 10: 100155. Abstract

Maguire J. 2019. Neuroactive steroids and GABAergic involvement in the neuroendocrine dysfunction associated with major depressive disorder and postpartum depression. Front Cell Neurosci. 13: 83. Abstract

Melón LC, Nasman JT, John AS, Mbonu K, Maguire JL. 2019. Interneuronal δ-GABAA receptors regulate binge drinking and are necessary for the behavioral effects of early withdrawal. Neuropsychopharmacology 44: 425-434. Abstract

Payne JL, Maguire J. 2019. Pathophysiological mechanisms implicated in postpartum depression. Front Neuroendocrinol. 52: 165-180. Abstract

Melón L, Hammond R, Lewis M, Maguire J. 2018. A Novel, synthetic, neuroactive steroid is effective at decreasing depression-like behaviors and improving maternal care in preclinical models of postpartum depression. Front Endocrinol. 9: 703. Abstract

Maguire J. 2018. Interneurons and the ictal orchestra. Epilepsy Curr. 18: 184-186. Abstract

Molaie AM, Maguire J. 2018. Neuroendocrine abnormalities following traumatic brain injury: An important contributor to neuropsychiatric sequelae. Front Endocrinol. 9: 176. Abstract

Maguire J. 2018. Focal epilepsy: When the brakes on the network go kaput. Epilepsy Curr. 18: 123-124. Abstract

Maguire J. 2018. The relationship between GABA and stress… "it's complicated". J Physiol. 596: 1781-1782. Abstract

Hooper A, Fuller PM, Maguire J. 2018. Hippocampal corticotropin-releasing hormone neurons support recognition memory and modulate hippocampal excitability. PLoS One 13: e0191363. Abstract

Melón LC, Hooper A, Yang X, Moss SJ, Maguire J. 2017. Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology 90: 182-193. Abstract

Hooper A, Paracha R, Maguire J. 2017. Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors. Epilepsy Behav. 78: 124-133. Abstract

Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ. 2017. Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proc Natl Acad Sci USA 114: 11763-11768. Abstract

Davis P, Zaki Y, Maguire J, Reijmers LG. 2017. Cellular and oscillatory substrates of fear extinction learning. Nat Neurosci. 20: 1624-1633. Abstract

Maguire J. 2017. Spare the neuron, spoil the network. Epilepsy Curr. 169-170. Abstract

Maguire J. 2017. Calming down during coming of age. Epilepsy Curr. 17: 57-59. Abstract

Fuchs T, Jefferson SJ, Hooper A, Yee PP, Maguire J, Luscher B. 2017. Disinhibition of somatostatin-positive interneurons by deletion of postsynaptic GABAA receptors. Mol Psychiatry 22: 787. Abstract

Maguire J. 2016. Synaptic plasticity and context-dependent behavioral responses expand the repertoire of stress reactivity. Bioessays 38: 1066-1067.  Abstract

MacKenzie G, O'Toole KK, Maguire J. 2016. Compromised GABAergic inhibition contributes to tumor-associated epilepsy. Epilespy Res 126:185-196. Abstract

Maguire J. 2016. Neurosteroid deficiency associated with epilepsy. Epilepsy Curr. 16: 108-109. Abstract

Maguire J. 2016. Epileptogenesis: More than just the latent period. Epilepsy Curr. 16: 31-33. Abstract

Lee V, MacKenzie G, Hooper A, Maguire J. 2016. Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus 26: 1276-1290 . Abstract

Maguire J, Mody I. 2016. Behavioral deficits in juveniles mediated by maternal stress hormones in mice. Neural Plast. 2016:2762518.  Abstract

Camille Melón L, Maguire J. 2015. GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function. J Steroid Biochem Mol Biol. 160: 196-203. Abstract

Sivakumaran S, Maguire J. 2015. Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. Epilepsia 57: 222-232. Abstract

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. 2015. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci USA 112: 14805-14810. Abstract

Hooper A, Maguire J 2015. Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus 26: 41-53.   Abstract

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. 2015. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices in vitro and in vivo. J Neurosci. 35: 8291-8286. Abstract

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci USA 111: 3523-3528. Abstract

MacKenzie G, Maguire J. 2015. Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility. Epilepsy Res. 109C:13-27. Abstract

Andresen L, Hampton D, Taylor A, Morel L, Yang Y, Maguire J, Dulla CG. 2014. Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Neurobiol Dis. 71: 305-316. Abstract

Maguire J. 2014. Stress-induced plasticity of GABAergic inhibition. Front Cell Neurosci. 8: 157. Abstract

Abramian AM, Comenencia-Ortiz E, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ. 2014. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc Natl Acad Sci. USA 111: 7132-7137. Abstract

Maguire J. 2014. Plasticity in the GABAergic regulation of the HPA axis. Bioessays 36: 546. Abstract

Lee V, Maguire J. 2014. The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type. Front Neural Circuits 8: 3. Abstract

Lee V, Sarkar J, Maguire J. 2014. Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology 41: 75-88. Abstract

Mackenzie G, Maguire J. 2014. The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders. Psychopharmacol (Berl) 231: 3333-3342. Abstract

O'Toole KK, Hooper A, Wakefield S, Maguire J. 2014. Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res. 108: 29-43. Abstract