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Graduate School of Biomedical Sciences

Recent Publications from the Leong Lab

Lin YP, Tan X, Caine JA, Castellanos M, Chaconas G, Coburn J, Leong JM. 2020. Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C. PLoS Pathog. 16: e1008516. Abstract

Siwapornchai N, Lee JN, Tchalla EYI, Bhalla M, Yeoh JH, Roggensack SE, Leong JM, Bou Ghanem EN. 2020. Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL-10 production. J Leukoc Biol. doi: 10.1002/JLB.4MA0120-115RR. Abstract

Adams W, Bhowmick R, Bou Ghanem EN, Wade K, Shchepetov M, Weiser JN, McCormick BA, Tweten RK, Leong JM. 2019. Pneumolysin induces 12-lipoxygenase-dependent neutrophil migration during Streptococcus pneumoniae infection. J Immunol. pii: ji1800748. doi: 10.4049/jimmunol.1800748. Abstract

Balasubramanian S, Osburne MS, BrinJones H, Tai AK, Leong JM. 2019. Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection. PLoS Pathog. 15: e1007494. Abstract

Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA. 2018. Transporters MRP1 and MRP2 regulate opposing inflammatory signals to control transepithelial neutrophil migration during Streptococcus pneumoniae lung infection. mSphere 3(4). Abstract

Bou Ghanem EN, Maung NHT, Siwapornchai N, Goodwin AE, Clark S, Muñoz-Elías EJ, Camilli A, Gerstein RM, Leong JM. 2018. Nasopharyngeal exposure to Streptococcus pneumoniae induces extended age-dependent protection against pulmonary infection mediated by antibodies and CD138+ Cells. J Immunol. 201:3471. Abstract

Bernard Q, Smith AA, Yang X, Koci J, Foor SD, Cramer SD, Zhuang X, Dwyer JE, Lin YP, Mongodin EF, Marques A, Leong JM, Anguita J, Pal U. 2018. Plasticity in early immune evasion strategies of a bacterial pathogen. Proc Natl Acad Sci USA Epub ahead of print. Abstract

Knoll LJ, Hogan DA, Leong JM, Heitman J, Condit RC. 2018. Pearls collections: What we can learn about infectious disease and cancer. PLoS Pathog 14: 31006915. Abstract

Lin YP, Leong JM. 2017. Characterization of Borrelia burgdorferi binding to mammalian cells and extracellular matrix. Methods Mol Biol 1690: 57-67. Abstract

Caine JA, Lin YP, Kessler JR, Sato H, Leong JM, Coburn J. 2017. Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival. Cell Microbiol. Epub ahead of print.  Abstract

Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA 2017. Cytosolic phospholipase A2α promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection. Infect Immun. 85: e00280-17. Abstract

Bou Ghanem EN, Lee JN, Joma BH, Meydani SN, Leong JM, Panda A. 2017. The Alpha-tocopherol form of Vitamin E boosts elastase activity of human PMNs and their ability to kill Streptococcus pneumoniae. Front Cell Infect Microbiol. 7:161.  Abstract

Flowers LJ, Bou Ghanem EN, Leong JM. 2016. Synchronous disease kinetics in a murine model for enterohemorrhagic E. coli infection using food-borne inoculation. Front Cell Infect Microbiol. 6:138. Synchronous Disease Kinetics in a Murine Model for Enterohemorrhagic E. coli Infection Using Food-Borne Inoculation. Abstract

Jandhyala DM, Wong J, Mantis NJ, Magun BE, Leong JM, Thorpe CM. 2016. A novel Zak knockout mouse with a defective ribotoxic stress response. Toxins (Basel) 8: 9. Abstract

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. 2015. Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment. PLoS Pathog. 11: e1005126.  Abstract

Yang X, Lin YP, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U. 2015. Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection. Cell Microbiol. 18: 97-110.  Abstract

Lin YP, Bhowmick R, Coburn J, Leong JM. 2015. Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. Cell Microbiol. 17: 1464-1476. Abstract

Bou Ghanem EN, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN. 2014. The α-yocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J. Immunol. 194: 1090-1099. Abstract

Lin YP, Chen Q, Ritchie JA, Dufour NP, Fischer JR, Coburn J, Leong JM. 2014. Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization. Cell Microbiol. 17: 860-875. Abstract

DesRochers TM, Kimmerling EP, Jandhyala DM, El-Jouni W, Zhou J, Thorpe C, Leong JM, Kaplan DL. 2014. The effects of shiga toxin type 2 on a bioengineered 3D model of human renal tissue. Infect Immun. 83: 28-38. Abstract>

Lin YP, Benoit V, Yang X, Martínez-Herranz R, Pal U, Leong JM. 2014. Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the Lyme disease spirochete. PLoS Pathog. 10: PLoS Pathog. 10: e1004238. Abstract

Battle SE, Brady MJ, Vanaja SK, Leong JM, Hecht GA. 2014. Infect Immun. Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation. 82: 3713-3722. Abstract

Fortune DE, Lin YP, Deka RK, Groshong AM, Moore BP, Hagman KE, Leong JM, Tomchick DR, Blevins JS. 2014. Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection. Infect Immun. 82: 3186-3198. Abstract

Kailasan Vanaja S, Rathinam VA, Atianand MK, Kalantari P, Skehan B, Fitzgerald KA, Leong JM. 2014. Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome. Proc Natl Acad Sci USA 111: 7765-7770. Abstract