My group conducts a wide variety of original research with particular experience in large retrospective analyses of existing databases. We also perform extensive collaborative research both with basic science and clinical researchers as well as perform methodological research in big data methods. We have significant experience in collaborative and methodological work in biostatistics and bioinformatics, including investigating the translational and clinical significance of genes and pathways using retrospective data analysis, and in developing predictive genomic signatures for disease. In terms of methodology development, we have particular experience in genomic network discovery, in pathway analysis, in approaches for the development of high dimensional genomic prediction models, and in the development of network methods for the analysis and visualization of comorbidity networks derived from EMR (Electronic Medical Record) or medical claims data.