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Graduate School of Biomedical Sciences

Recent Publications from the Kritzer Lab

Cerulli RA, Shehaj L, Tosic I, Jiang K, Wang J, Frank DA, Kritzer JA. 2020. Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors. Bioorg Med Chem. 28: 115542. Abstract

Cerulli RA, Shehaj L, Brown HF, Pace JR, Mei Y, Kritzer JA. 2020. Stapled peptide inhibitors of autophagy adapter LC3B. Chembiochem. doi: 10.1002/cbic.202000212. Abstract

Cerulli RA, Kritzer JA. 2019. Phosphotyrosine isosteres: past, present and future. Org Biomol Chem. 28. doi: 10.1039/c9ob01998g. Abstract

Cerulli RA, Kritzer JA. 2019. Stringing together a universal influenza antibody. Biochemistry Epub ahead of print. Abstract

Cummings AE, Miao J, Slough DP, McHugh SM, Kritzer JA, Lin YS. 2019.  β-branched amino acids stabilize specific conformations of cyclic hexapeptides. Biophys J. Epub ahead of print. Abstract

Peraro L, Kritzer J. 2018. Getting in: Emerging methods and design principles for cell-penetrant peptides. Angew Chem Int Ed Engl. Epub ahead of print. Abstract

Slough DP, McHugh SM, Cummings AE, Dai P, Pentelute BL, Kritzer JA, Lin YS. 2018. Designing well-structured cyclic pentapeptides based on sequence-structure relationships. J Phys Chem B 122: 3908-3919. Abstract

Kritzer JA, Freyzon Y, Lindquist S. 2018. Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway. FEMS Yeast Res. Epub ahead of print. Abstract

Kamens AJ, Mientkiewicz KM, Eisert RJ, Walz JA, Mace CR, Kritzer JA. 2018. Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorg Med Chem. 26: 1206-1211. Abstract

Siegert TR, Bird M, Kritzer JA. 2017. Identifying loop-mediated protein-protein interactions using LoopFinder. Methods Mol Biol. 1561: 255-277. Abstract

Kritzer JA. 2016. Stapled peptides: How to be quick on the uptake. Nat Chem Biol. 12: 764-765. Abstract

Peraro L, Siegert TR, Kritzer JA. 2016. Conformational restriction of peptides using dithiol bis-alkylation. Methods Enzymol. 580:303-332. Abstract

Charkoudian LK, Sampson NS, Kumar K, Kritzer JA 2016. Designing convergent chemistry curricula. Nat Chem Biol. 6: 382-386.  Abstract

Quartararo JS, Eshelman MR, Peraro L, Yu H, Baleja JD, Lin YS, Kritzer JA. 2014. A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake. Bioorg Med Chem. 22: 6387-6391.  Abstract

Eshelman MR, Aldous AR, Neupane KP, Kritzer JA. 2014. Solution structure of a designed cyclic peptide ligand for nickel and copper ions. Tetrahedron 70: 7651-7654.  Abstract

Gavenonis J, Sheneman BA, Siegert TR, Eshelman MR, Kritzer JA. 2014. Comprehensive analysis of loops at protein-protein interfaces for macrocycle design. Nat Chem Biol. 10: 716-722.  Abstract

Kamens AJ, Eisert RJ, Corlin T, Baleja JD, Kritzer JA. 2014. Structured cyclic peptides that bind the EH domain of EHD1. Biochemistry 53: 4758-4760.  Abstract

Gavenonis J, Jonas NE, Kritzer JA. 2014. Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix. Bioorgan Med Chem. 22: 3989-3993.  Abstract

Neupane KP, Aldous AR, Kritzer JA. 2014. Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs. J Inorgan Biochem. 139: 65076.  Abstract

Choudary SK, Qiu J, Plaut AG, Kritzer JA. 2013. Versatile substrates and probes for IgA1 protease activity. Chembiochem. 14: 2007-2012.  Abstract

Neupane KP, Aldous AR, Kritzer JA. 2013. Macrocyclization of the ATCUN motif controls metal binding and catalysis. Inorgan Biochem. 52: 2729-2735.  Abstract

Bock JE, Gavenonis J, Kritzer JA. 2013. Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints. ACS Biochem 8: 488-499.  Abstract

Kritzer JA. 2012. The secret of MIM: a novel, MCL-1-specific small molecule. Chem Biol. 19: 1082-1083.  Abstract

Quartararo JS, Wu P, Kritzer JA. 2012. Peptide bicycles that inhibit the Grb2 SH2 domain. Chembiochem 13: 1490-1496.  Abstract