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Graduate School of Biomedical Sciences

Recent Publications from the Kaplan Lab

Cheng W, Ding Z, Zheng X, Lu Q, Kong X, Zhou X, Lu G, Kaplan DL. 2020. Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration. Biomater Sci. doi: 10.1039/d0bm00104j. Abstract

Taylor JS, Yavuz B, Zeki J, Wood L, Ikegaki N, Coburn J, Harrington K, Shimada H, Kaplan DL, Chiu B. 2020. Enhancing sustained-release local therapy: Single versus dual chemotherapy for the treatment of neuroblastoma. Surgery pii: S0039-6060(20)30053-2. doi: 10.1016/j.surg.2020.01.012. Abstract

Fish KD, Rubio NR, Stout AJ, Yuen JSK, Kaplan DL. 2020. Prospects and challenges for cell-cultured fat as a novel food ingredient. Trends Food Sci Technol. 98: 53-67. Abstract

Yeo J, Qiu Y, Jung GS, Zhang YW, Buehler MJ, Kaplan DL. 2020. Adverse effects of Alport syndrome-related Gly missense mutations on collagen type IV: Insights from molecular simulations and experiments. Biomaterials 240:119857. doi: 10.1016/j.biomaterials.2020.119857. Abstract

Mu X, Fitzpatrick V, Kaplan DL. 2020. From silk spinning to 3D printing: Polymer manufacturing using directed hierarchical molecular assembly. Adv Haelth Mater. e1901552. doi: 10.1002/adhm.201901552. Abstract

Rouleau N, Cantley WL, Liaudanskaya V, Berk A, Du C, Rusk W, Peirent E, Koester C, Nieland TJF, Kaplan DL. 2020. A long-living bioengineered neural tissue platform to study neurodegeneration. Macromol Biosci. 17:e2000004. doi: 10.1002/mabi.202000004. Abstract

Xu G, Ding Z, Lu Q, Zhang X, Zhou X, Xiao L, Lu G, Kaplan DL. 2020. Electric field-driven building blocks for introducing multiple gradients to hydrogels. Protein Cell doi: 10.1007/s13238-020-00692-z. Abstract

Smokelin I, Mizzoni C, Erndt-Marino J, Kaplan D, Georgakoudi I. 2020. Optical changes in THP-1 macrophage metabolism in response to pro- and anti-inflammatory stimuli reported by label-free two-photon imaging. J Biomed Opt. 25: 1-14. Abstract

Bonzanni M, Rouleau N, Levin M, Kaplan DL. 2020. Optogenetically induced cellular habituation in non-neuronal cells. PLoS One 15(1):e0227230. Abstract

Guo C, Li C, Vu HV, Hanna P, Lechtig A, Qiu Y, Mu X, Ling S, Nazarian A, Lin SJ, Kaplan DL. 2020. Thermoplastic moulding of regenerated silk. Nat Mater. 19: 102-108. Abstract

Raia NR, Jia D, Ghezzi CE, Muthukumar M, Kaplan DL. 2019. Characterization of silk-hyaluronic acid composite hydrogels towards vitreous humor substitutes. Biomaterials. 233: 119729. Abstract

Hasturk O, Jordan KE, Choi J, Kaplan DL. 2019. Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation. Biomaterials 232:119720. doi: 10.1016/j.biomaterials.2019.119720. Abstract

Bonzanni M, Payne SL, Adelfio M, Kaplan DL, Levin M, Oudin MJ. 2019. Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential. Biol Open. pii: bio.048553. doi: 10.1242/bio.048553. Abstract

Sood D, Cairns DM, Dabbi JM, Ramakrishnan C, Deisseroth K, Black LD 3rd, Santaniello S, Kaplan DL. 2019. Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix. Sci Rep. 9(1):17874. doi: 10.1038/s41598-019-54248-1. Abstract

Wang X, Guo C, Chen Y, Tozzi L, Szymkowiak S, Li C, Kaplan DL. 2019. Developing a self-organized tubulogenesis model of human renal proximal tubular epithelial cells in vitro. J Biomed Mater Res A Epub ahead of print. Abstract

Rodriguez M, Kluge JA, Smoot D, Kluge MA, Schmidt DF, Paetsch CR, Kim PS, Kaplan DL. 2019. Fabricating mechanically improved silk-based vascular grafts by solution control of the gel-spinning process. Biomaterials 23:119567. doi: 10.1016/j.biomaterials.2019.119567. Abstract

Parker RN, Wu WA, McKay TB, Xu Q, Kaplan DL. 2019. Design of silk-elastin-like protein nanoparticle systems with mucoadhesive properties. J Funct Biomater. 10(4). pii: E49. doi: 10.3390/jfb10040049. Abstract

Sood D, Tang-Schomer M, Pouli D, Mizzoni C, Raia N, Tai A, Arkun K, Wu J, Black LD 3rd, Scheffler B, Georgakoudi I, Steindler DA, Kaplan DL. 2019. 3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors. Nat Commun. 10(1):4529. doi: 10.1038/s41467-019-12420-1. Abstract

Simsa R, Yuen J, Stout A, Rubio N, Fogelstrand P, Kaplan DL. 2019. Extracellular heme proteins influence bovine myosatellite cell proliferation and the color of cell-based meat. Foods 8(10). pii: E521. doi: 10.3390/foods8100521. Abstract

Zhang Y, Raia N, Peterson A, Kaplan DL PhD, House MD. 2019. Injectable silk-based hydrogel as an alternative to cervical cerclage: a rabbit study. Tissue Eng Part A. Epub ahead of print. Abstract

Roh TT, Chen Y, Paul HT, Guo C, Kaplan DL. 2019. 3D bioengineered tissue model of the large intestine to study inflammatory bowel disease. Biomaterials 225: 119517. Abstract

McKay TB, Parker RN, Hawker MJ, McGill M, Kaplan DL. 2019. Silk-based therapeutics targeting Pseudomonas aeruginosa. J Funct Biomater. 10(3). pii: E41. doi: 10.3390/jfb10030041. Abstract

McKay TB, Ford A, Wang S, Cairns DM, Parker RN, Deardorff PM, Ghezzi CE, Kaplan DL. 2019. Assembly and application of a three-dimensional human corneal tissue model. Curr Protoc Toxicol. 81: e84. Abstract

Wang C, Xia K, Zhang Y, Kaplan DL. 2019. Silk-based advanced material for soft electronics. Acc Chem Res. Epub ahead of print. Abstract

Mooring M, Fowl BH, Lum SZC, Liu Y, Yao K, Softic S, Kirchner R, Bernstein A, Singhi AD, Jay DG, Kahn CR, Camargo FD, Yimlamai D. 2019. Hepatocyte stress increases expression of YAP and TAZ in hepatocytes to promote parenchymal inflammation and fibrosis. Hepatology doi: 10.1002/hep.30928. Abstract

Franco AR, Fernandes EM, Rodrigues MT, Rodrigues FJ, Gomes ME, Leonor IB, Kaplan DL, Reis RL. 2019. Acta Biomater. pii: S1742-7061(19)30616-6. doi: 10.1016/j.actbio.2019.09.004. Abstract

Mu X, Wang Y, Guo C, Li Y, Ling S, Huang W, Cebe P, Hsu HH, De Ferrari F, Jiang X, Xu Q, Balduini A, Omenetto FG, Kaplan DL. 2019. 3D printing of silk protein structures by aqueous solvent-directed molecular assembly. Macromol Biosci.21:e1900191. doi: 10.1002/mabi.201900191. Abstract

Izzy S, Liu Q, Fang Z, Lule S, Wu L, Chung JY, Sarro-Schwartz A, Brown-Whalen A, Perner C, Hickman SE, Kaplan DL, Patsopoulos NA, El Khoury J, Whalen MJ. 2019. Time-dependent changes in microglia transcriptional networks following traumatic brain injury. Front Cell Neurosci. 13: 307. Abstract

Vidal Yucha SE, Tamamoto KA, Kaplan DL. 2019. The importance of the neuro-immuno-cutaneous system on human skin equivalent design. Cell Prolif. e12677. doi: 10.1111/cpr.12677. Abstract

Choi J, McGill M, Raia NR, Hasturk O, Kaplan DL. 2019. Silk hydrogels crosslinked by the fenton reaction. Adv Healthc Mater. Epub ahead of print. Abstract

Manousiouthakis E, Chen Y, Cairns D, Pollard R, Gerlovin K, Dente M, Razavi Y, Kaplan DL. 2019. Bioengineered in vitro enteric nervous system. J Tissue Eng Regen Med. Epub ahead of print. Abstract

Belton DJ, Plowright R, Kaplan DL, Perry CC. 2019. A robust spectroscopic method for the determination of protein conformational composition - Application to the annealing of silk. Acta Biomater. 73: 355-364. Abstract

Yavuz B, Chambre L, Kaplan DL. 2019. Extended release formulations using silk proteins for controlled delivery of therapeutics.Expert Opin Drug Deliv. Epub ahead of print. Abstract

Gong H, Wang J, Zhang J, Wu J, Zheng Z, Xie X, Kaplan DL, Li G, Wang X. 2019. Control of octreotide release from silk fibroin microspheres. Mater Sci Eng C Mater Biol Appl. 102: 820-828. Abstract

Raia NR, Bakaysa SL, Ghezzi CE, House MD, Kaplan DL. 2019. Ex vivo pregnant-like tissue model to assess injectable hydrogel for preterm birth prevention. J Biomed Mater Res B Appl Biomater. Epub ahead of print. Abstract

Yavuz B, Zeki J, Taylor J, Harrington K, Coburn JM, Ikegaki N, Kaplan DL, Chiu B. 2019. Silk reservoirs for local delivery of cisplatin for neuroblastoma treatment: In vitro and in vivo evaluations. J Pharm Sci. Epub ahead of print. Abstract

Yavuz B, Morgan JL, Herrera C, Harrington K, Perez-Ramirez B, LiWang PJ, Kaplan DL. 2019. Sustained release silk fibroin discs: Antibody and protein delivery for HIV prevention. J Control Release. 301: 1-12. Abstract

Gupta AK, Coburn JM, Davis-Knowlton J, Kimmerling E, Kaplan DL, Oxburgh L. 2019. Scaffolding kidney organoids on silk. J Tissue Eng Regen Med. Epub ahead of print. Abstract

Setayeshmehr M, Esfandiari E, Rafienia M, Hashemibeni B, Taheri-Kafrani A, Samadikuchaksaraei A, Kaplan DL PhD, Moroni L, Joghataei M. 2019. Hybrid and composite scaffolds based on extracellular matrices for cartilage tissue engineering. Tissue Eng Part B Rev. Epub ahead of print. Abstract

Bradner SA, Galaiya D, Raol N, Kaplan DL, Hartnick CJ. 2019. Silk protein bioresorbable, drug-eluting ear tubes: Proof-of-concept. Adv Health Mater. Epub ahead of print. Abstract