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Graduate School of Biomedical Sciences

Recent Publications from the Kaplan Lab

Shu T, Lv Z, Chen CT, Gu GX, Ren J, Cao L, Pei Y, Ling S, Kaplan DL. 2021. Mechanical training-driven structural remodeling: A rational route for outstanding highly hydrated silk materials. Small. Jul 19:e2102660. doi: 10.1002/smll.202102660. Abstract

Zhang S, Wang J, Zheng Z, Yan J, Zhang L, Li Y, Zhang J, Li G, Wang X, Kaplan D. 2021. Porous nerve guidance conduits reinforced with braided composite structures of silk/magnesium filaments for peripheral nerve repair. Acta Biomater. Jul 18:S1742-7061(21)00466-9. doi: 10.1016/j.actbio.2021.07.028. Abstract

Fitzpatrick V, Martín-Moldes Z, Deck A, Torres-Sanchez R, Valat A, Cairns D, Li C, Kaplan DL. 2021. Functionalized 3D-printed silk-hydroxyapatite scaffolds for enhanced bone regeneration with innervation and vascularization. Biomaterials. 276:120995. doi: 10.1016/j.biomaterials.2021.120995. Abstract

Liu L, Ding Z, Yang Y, Zhang Z, Lu Q, Kaplan DL. 2021. Asiaticoside-laden silk nanofiber hydrogels to regulate inflammation and angiogenesis for scarless skin regeneration. Biomater Sci. J9: 5227-5236. Abstract

Lu Q, Zhang F, Cheng W, Gao X, Ding Z, Zhang X, Lu Q, Kaplan DL.. 2021. Nerve guidance conduits with hierarchical anisotropic architecture for peripheral nerve regeneration. Adv Healthc Mater. 26:e2100427. doi: 10.1002/adhm.202100427. Abstract

Yang G, Jiang F, Lu Y, Lin S, Liu C, Li A, Kaplan DL, Zhang S, He Y, Huang C, Zhang W, Jiang X. 2021. Rapid construction and enhanced vascularization of microtissue using a magnetic control method. Biofabrication. 13(3). doi: 10.1088/1758-5090/abe4c2. Abstract

Sahoo JK, Hasturk O, Choi J, Montero MM, Descoteaux ML, Laubach IA, Kaplan DL. 2021. Sugar functionalization of silks with pathway-controlled substitution and properties. Adv Biol. Apr 30:e2100388. doi: 10.1002/adbi.202100388. Abstract

Yang T, Han H, Chen Y, Yang L, Parker R, Li Y, Kaplan DL, Xu Q. 2021. Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model. Bioact Mater. 6: 3671-3677. doi: 10.1016/j.bioactmat.2021.03.027. Abstract

Wu L, Gao S, Zhao T, Tian K, Zheng T, Zhang X, Xiao L, Ding Z, Lu Q, Kaplan DL. 2021. Pressure-driven spreadable deferoxamine-laden hydrogels for vascularized skin flaps. Biomater Sic. 9: 3162-3170. Abstract

Fu Y, Xie X, Wang Y, Liu J, Zheng Z, Kaplan DL, Wang X. 2021. Sustained photosynthesis and oxygen generation of microalgae-embedded silk fibroin hydrogels. ACS Biomater Sci Eng. Apr 9. doi: 10.1021/acsbiomaterials.1c00168. Abstract

Zhang X, Xiao L, Ding Z, Lu Q, Kaplan DL. 2021. Fragile-tough mechanical reversion of silk materials via tuning supramolecular assembly. ACS Biomater Sci Eng. Apr 9. doi: 10.1021/acsbiomaterials.1c00181. Abstract

Hu Z, Yan S, Li X, You R, Zhang Q, Kaplan DL. 2021. Natural silk nanofibril aerogels with distinctive filtration capacity and heat-retention performance. ACS Nano. Apr 13. doi: 10.1021/acsnano.1c00346. Abstract

Mu X, Agostinacchio F, Xiang N, Pei Y, Khan Y, Guo C, Cebe P, Motta A, Kaplan DL. 2021. Recent advances in 3D printing with protein-based inks. Prog Polym Sci.115:101375. Abstract

Rouleau N, Cairns DM, Rusk W, Levin M, Kaplan DL. 2021. Learning and synaptic plasticity in 3D bioengineered neural tissues. Neurosci Lett. 750:135799. doi: 10.1016/j.neulet.2021.135799. Abstract

Szymkowiak S, Sandler N, Kaplan DL. 2021. Aligned silk sponge fabrication and perfusion culture for scalable proximal tubule tissue engineering. ACS Appli Mater Interfaces. Feb 23. doi: 10.1021/acsami.1c00548. Abstract

Rouleau N, Murugan NJ, Kaplan DL. 2021. Toward studying cognition in a dish. Trends Cogn Sci. Feb 2:S1364-6613(21)00007-3. doi: 10.1016/j.tics.2021.01.005. Abstract

Ding Z, Zhang Y, Guo P, Duan T, Cheng W, Guo Y, Zheng X, Lu G, Lu Q, Kaplan DL. 2021. Injectable desferrioxamine-laden silk nanofiber hydrogels for accelerating diabetic wound healing. ACS Biomater Sci Eng. Feb 1. doi: 10.1021/acsbiomaterials.0c01502. Abstract

Dingle YL, Bonzanni M, Liaudanskaya V, Nieland TJF, Kaplan DL. 2021. Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture. STAR Protoc. 2(1):100292. doi: 10.1016/j.xpro.2020.100292. Abstract

Simsa R, Rothenbücher T, Gürbüz H, Ghosheh N, Emneus J, Jenndahl L, Kaplan DL, Bergh N, Serrano AM, Fogelstrand P. 2021. Brain organoid formation on decellularized porcine brain ECM hydrogels. PLoS One 16(1):e0245685. doi: 10.1371/journal.pone.0245685. Abstract

McNamara SL, McCarthy EM, Schmidt DF, Johnston SP, Kaplan DL. 2021. Rheological characterization, compression, and injection molding of hydroxyapatite-silk fibroin composites. Biomaterials. 269:120643. doi: 10.1016/j.biomaterials.2020.120643. Abstract

Xie X, Zheng Z, Wang X, Lee Kaplan D. 2021. Low-density silk nanofibrous aerogels: Fabrication and applications in air filtration and oil/water purification. ACS Nano. doi: 10.1021/acsnano.0c07896. Abstract

Liu J, Huang R, Li G, Kaplan DL, Zheng Z, Wang X. 2021. Generation of nano-pores in silk fibroin films using silk nanoparticles for full-thickness wound healing. Biomacromolecules. doi: 10.1021/acs.biomac.0c01411. Abstract

Pei Y, Jordan KE, Xiang N, Parker RN, Mu X, Zhang L, Feng Z, Chen Y, Li C, Guo C, Tang K, Kaplan DL. 2021. Liquid-exfoliated mesostructured collagen from the bovine Achilles tendon as building blocks of collagen membranes. ACS Appl Mater Interfaces.Jan 5. doi: 10.1021/acsami.0c20330. Abstract

Choi J, Hasturk O, Mu X, Sahoo JK, Kaplan DL. 2021. Silk hydrogels with controllable formation of dityrosine, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylalanine-Fe3+ complexes through chitosan particle-assisted Fenton reactions. Biomacromolecules Jan 6. doi: 10.1021/acs.biomac.0c01539. Abstract

Belda Marín C, Fitzpatrick V, Kaplan DL, Landoulsi J, Guénin E, Egles C. 2020. Silk polymers and nanoparticles: A powerful combination for the design of versatile biomaterials. Front Chem. 8:604398. doi: 10.3389/fchem.2020.604398. Abstract

Yao Y, Allardyce BJ, Rajkhowa R, Guo C, Mu X, Hegh D, Zhang J, Lynch P, Wang X, Kaplan DL, Razal JM. 2020. Spinning regenerated silk fibers with improved toughness by plasticizing with low molecular weight silk. Biomacromolecules. 18. doi: 10.1021/acs.biomac.0c01545. Abstract

Agostinacchio F, Mu X, Dirè S, Motta A, Kaplan DL. 2020. In situ 3D printing: Opportunities with silk inks. Trends Biotechnol. 2:S0167-7799(20)30298-5. doi: 10.1016/j.tibtech.2020.11.003. Abstract

Rubio NR, Xiang N, Kaplan DL. 2020. Plant-based and cell-based approaches to meat production. Nat Commun 11(1):6276. Abstract

Mu X, Sahoo JK, Cebe P, Kaplan DL. 2020. Photo-crosslinked silk fibroin for 3D printing. Polymers 12: E2936. doi: 10.3390/polym12122936. Abstract

Pollard RE, McKay TB, Ford A, Cairns DM, Georgakoudi I, Kaplan DL. 2020. Induction of irritation and inflammation in a 3D innervated tissue model of the human cornea. ACS Biomater Sci Eng. 6: 6886-6895. Abstract

Adelfio M, Szymkowiak S, Kaplan DL. 2020. Matrigel-free laminin-entactin matrix to induce human renal proximal tubule structure formation in vitro. ACS Biomater Sci Eng. 6: 6618-6625. Abstract

Narayan OP, Mu X, Hasturk O, Kaplan DL. 2020. Dynamically tunable light responsive silk-elastin-like proteins. Acta Biomater. 13:S1742-7061(20)30732-7. doi: 10.1016/j.actbio.2020.12.018. Abstract

Wang F, Guo C, Yang Q, Li C, Zhao P, Xia Q, Kaplan DL. 2020. Protein composites from silkworm cocoons as versatile biomaterials. Acta Biomater. 26:S1742-7061(20)30690-5. doi: 10.1016/j.actbio.2020.11.037. Abstract

Lule S, Wu L, Sarro-Schwartz A, Edmiston Iii WJ, Izzy S, Songtachalert T, Ahn SH, Fernandes ND, Jin G, Chung JY, Balachandran S, Lo EH, Kaplan D, Degterev A, Whalen MJ. 2020. Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 19:271678X20973609. doi: 10.1177/0271678X20973609. Abstract

Martín-Moldes Z, Barreiro DL, Buehler MJ, Kaplan DL. 2020. Effect of the silica nanoparticle size on the osteoinduction of biomineralized silk-silica nanocomposites. Acta Biomaterl. 4:S1742-7061(20)30641-3. doi: 10.1016/j.actbio.2020.10.043. Abstract

Chambre L, Martín-Moldes Z, Parker RN, Kaplan DL. 2020. Bioengineered elastin- and silk-biomaterials for drug and gene delivery. Adv Drug Deliv Rev. 17:S0169-409X(20)30145-9. doi: 10.1016/j.addr.2020.10.008. Abstract

Stout AJ, Mirliani AB, Soule-Albridge EL, Cohen JM, Kaplan DL. 2020. Engineering carotenoid production in mammalian cells for nutritionally enhanced cell-cultured foods. Metab Eng. 2:S1096-7176(20)30120-8. doi: 10.1016/j.ymben.2020.07.011. Abstract

Roh TT, Chen Y, Rudolph S, Gee M, Kaplan DL. 2020. In vitro models of intestine innate immunity. Trends Biotechnol. 24:S0167-7799(20)30204-3. doi: 10.1016/j.tibtech.2020.07.009. Abstract

Huang Y, Fitzpatrick V, Zheng N, Cheng R, Huang H, Ghezzi C, Kaplan DL, Yang C. 2020. Self-folding 3D silk biomaterial rolls to facilitate axon and bone regeneration. Adv Healthc Mater. 31:e2000530. doi: 10.1002/adhm.202000530. Abstract

Jaleel Z, Zhou S, Martín-Moldes Z, Baugh LM, Yeh J, Dinjaski N, Brown LT, Garb JE, Kaplan DL. 2020. Expanding canonical spider silk properties through a DNA combinatorial approach. Materials (Basel). 13: E3596. Abstract

Rouleau N, Bonzanni M, Erndt-Marino JD, Sievert K, Ramirez CG, Rusk W, Levin M, Kaplan DL. 2020. A 3D tissue model of traumatic brain injury with excitotoxicity that is inhibited by chronic exposure to gabapentinoids. Biomolecules. 10: E1196. Abstract

Daley MC, Bonzanni M, MacKenzie AM, Kaplan DL, Black LD 3rd. 2020. The effects of membrane potential and extracellular matrix composition on vascular differentiation of cardiac progenitor cells. Biochem Biophys Res Commun. 530: 240-245. Abstract

Yavuz B, Chambre L, Harrington K, Kluge J, Valenti L, Kaplan DL. 2020. Silk fibroin microneedle patches for the sustained release of levonorgestrel. ACS Appl Bio Mater. 3: 5375-5382. Abstract

Bonzanni M, Bockley KM, Kaplan DL. 2020. On the effect of neuronal spatial subsampling in small-world networks. Eur J Neurosci. doi: 10.1111/ejn.14937. Abstract

Dingle YL, Liaudanskaya V, Finnegan LT, Berlind KC, Mizzoni C, Georgakoudi I, Nieland TJF, Kaplan DL. 2020. Functional characterization of three-dimensional cortical cultures for in vitro modeling of brain networks. iScience 23: 101434. Abstract

Zhao X, Glass Z, Chen J, Yang L, Kaplan DL, Xu Q. 2020. mRNA delivery using bioreducible lipidoid nanoparticles facilitates neural differentiation of human mesenchymal stem cells. Adv Healthc Mater. 19:e2000938. Abstract

Rouleau N, Murugan NJ, Rusk W, Koester C, Kaplan DL. 2020. Matrix deformation with ectopic cells induced by rotational motion in bioengineered neural tissues. Ann Biomed Eng. doi: 10.1007/s10439-020-02561-6. Abstract

Sahoo JK, Choi J, Hasturk O, Laubach I, Descoteaux ML, Mosurkal S, Wang B, Zhang N, Kaplan DL. 2020. Silk degumming time controls horseradish peroxidase-catalyzed hydrogel properties. Biomater Sci. doi: 10.1039/d0bm00512f. Abstract

Wang Y, Huang W, Wang Y, Mu X, Ling S, Yu H, Chen W, Guo C, Watson MC, Yu Y, Black LD 3rd, Li M, Omenetto FG, Li C, Kaplan DL. 2020. Stimuli-responsive composite biopolymer actuators with selective spatial deformation behavior. Proc Natl Acad Sci USA. pii: 202002996. doi: 10.1073/pnas.2002996117. Abstract

Cairns DM, Rouleau N, Parker RN, Walsh KG, Gehrke L, Kaplan DL. 2020. A 3D human brain-like tissue model of herpes-induced Alzheimer's disease. Sci Adv. 6;6(19):eaay8828. doi: 10.1126/sciadv.aay8828. Abstract

Liaudanskaya V, Chung JY, Mizzoni C, Rouleau N, Berk AN, Wu L, Turner JA, Georgakoudi I, Whalen MJ, Nieland TJF, Kaplan DL. 2020. Modeling controlled cortical impact injury in 3D brain-like tissue cultures. Adv Health Mater. 13:e2000122. doi: 10.1002/adhm.202000122. Abstract

Parker RN, Cairns DM, Wu WA, Jordan K, Guo C, Huang W, Martin-Moldes Z, Kaplan DL. 2020. Smart material hydrogel transfer devices fabricated with stimuli-responsive silk-elastin-like proteins. Adv Healthc Mater.13: e2000266. doi: 10.1002/adhm.202000266. Abstract

Zheng X, Ding Z, Cheng W, Lu Q, Kong X, Zhou X, Lu G, Kaplan DL. 2020. Microskin-inspired injectable MSC-laden hydrogels for scarless wound healing with hair follicles. Adv Healthc Mater. e2000041. doi: 10.1002/adhm.202000041. Abstract

McGill M, Grant JM, Kaplan DL. 2020. Enzyme-mediated conjugation of peptides to silk fibroin for facile hydrogel functionalization. Ann Biomed Eng. doi: 10.1007/s10439-020-02503-2. Abstract

Sundelacruz S, Moody AT, Levin M, Kaplan DL. 2020. Membrane potential depolarization alters calcium flux and phosphate signaling during osteogenic differentiation of human mesenchymal stem cells. Bioelectricity 1: 56-66. Abstract

Kamaldinov T, Erndt-Marino J, Levin M, Kaplan DL, Hahn MS. 2020. Assessment of enrichment of human mesenchymal stem cells based on plasma and mitochondrial membrane potentials. Bioelectricity 2: 21-32. Abstract

Erndt-Marino J, Yeisley DJ, Chen H, Levin M, Kaplan DL, Hahn MS. 2020. Interferon-gamma stimulated murine macrophages in vitro: Impact of ionic composition and osmolarity and therapeutic implications. Bioelectricity 2: 48-58. Abstract

Cheng W, Ding Z, Zheng X, Lu Q, Kong X, Zhou X, Lu G, Kaplan DL. 2020. Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration. Biomater Sci. doi: 10.1039/d0bm00104j. Abstract

Taylor JS, Yavuz B, Zeki J, Wood L, Ikegaki N, Coburn J, Harrington K, Shimada H, Kaplan DL, Chiu B. 2020. Enhancing sustained-release local therapy: Single versus dual chemotherapy for the treatment of neuroblastoma. Surgery pii: S0039-6060(20)30053-2. doi: 10.1016/j.surg.2020.01.012. Abstract

Fish KD, Rubio NR, Stout AJ, Yuen JSK, Kaplan DL. 2020. Prospects and challenges for cell-cultured fat as a novel food ingredient. Trends Food Sci Technol. 98: 53-67. Abstract

Yeo J, Qiu Y, Jung GS, Zhang YW, Buehler MJ, Kaplan DL. 2020. Adverse effects of Alport syndrome-related Gly missense mutations on collagen type IV: Insights from molecular simulations and experiments. Biomaterials 240:119857. doi: 10.1016/j.biomaterials.2020.119857. Abstract

Mu X, Fitzpatrick V, Kaplan DL. 2020. From silk spinning to 3D printing: Polymer manufacturing using directed hierarchical molecular assembly. Adv Haelth Mater. e1901552. doi: 10.1002/adhm.201901552. Abstract

Rouleau N, Cantley WL, Liaudanskaya V, Berk A, Du C, Rusk W, Peirent E, Koester C, Nieland TJF, Kaplan DL. 2020. A long-living bioengineered neural tissue platform to study neurodegeneration. Macromol Biosci. 17:e2000004. doi: 10.1002/mabi.202000004. Abstract

Xu G, Ding Z, Lu Q, Zhang X, Zhou X, Xiao L, Lu G, Kaplan DL. 2020. Electric field-driven building blocks for introducing multiple gradients to hydrogels. Protein Cell doi: 10.1007/s13238-020-00692-z. Abstract

Smokelin I, Mizzoni C, Erndt-Marino J, Kaplan D, Georgakoudi I. 2020. Optical changes in THP-1 macrophage metabolism in response to pro- and anti-inflammatory stimuli reported by label-free two-photon imaging. J Biomed Opt. 25: 1-14. Abstract

Bonzanni M, Rouleau N, Levin M, Kaplan DL. 2020. Optogenetically induced cellular habituation in non-neuronal cells. PLoS One 15(1):e0227230. Abstract

Guo C, Li C, Vu HV, Hanna P, Lechtig A, Qiu Y, Mu X, Ling S, Nazarian A, Lin SJ, Kaplan DL. 2020. Thermoplastic moulding of regenerated silk. Nat Mater. 19: 102-108. Abstract