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Graduate School of Biomedical Sciences

Recent Publications from the Jacob Lab

Alexander JM, Pirone A, Jacob MH. 2020. Excessive β-catenin in excitatory neurons results in reduced social and increased repetitive behaviors and altered expression of multiple genes linked to human autism. Front Synaptic Neurosci. 12:14. doi: 10.3389/fnsyn.2020.00014.  Abstract

Wickham RJ, Alexander JM, Eden LW, Valencia-Yang M, Llamas J, Aubrey JR, Jacob MH. 2019. Learning impairments and molecular changes in the brain caused by β-catenin loss. Hum Mol Genet. 28: 2965-2975.  Abstract

Pirone A, Alexander JM, Koenig JB, Cook-Snyder DR, Palnati M, Wickham RJ, Eden L, Shrestha N, Reijmers L, Biederer T, Miczek KA, Dulla CG, Jacob MH. 2018. Social stimulus causes aberrant activation of the medial prefrontal cortex in a mouse model with autism-like behaviors. Fron Synaptic Neurosci. 10: 35.  Abstract

Pirone A, Alexander J, Lau LA, Hampton D, Zayachkivsky A, Yee A, Yee A, Jacob MH, Dulla CG. 2017. APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures. Neurobiol Dis. 98: 149-157.  Abstract

Hickman TT, Liberman MC, Jacob MH. 2015. Adenomatous polyposis coli protein deletion in efferent olivocochlear neurons perturbs afferent synaptic maturation and reduces the dynamic range of hearing. J Neurosci. 35: 9236-9245. Abstract

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. New molecular insights into cognitive and autistic-like disabilities. Mol Psychiatry 19: 1053. Abstract

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. Mol Psychiatry 19: 133-142. Abstract

Scholl ES, Pirone A, Cox DH, Duncan RK, Jacob MH. 2014. Alternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levels. Channels (Austin). 8: 62-75. Abstract

Rosenberg MM, Yang F, Mohn JL, Storer EK, Jacob MH. 2010. The postsynaptic APC multi-protein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo. J Neurosci. 30: 11073-11085. Abstract

Hone AJ, Whiteaker P, Mohn JL, Jacob MH, Michael McIntosh J. 2010. Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling α7 nicotinic acetylcholine receptors. J Neurosci. 114: 994-1006 Abstract