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Graduate School of Biomedical Sciences

Recent Publications from the L Hu Lab

Cornacchione LP, Hu LT. 2020. Hydrogen peroxide-producing pyruvate oxidase from Lactobacillus delbrueckii is catalytically activated by phosphotidylethanolamine. BMC Microbiol. 20(1):128. doi: 10.1186/s12866-020-01788-6. Abstract

Cornacchione LP, Klein BA, Duncan MJ, Hu LT. 2019. Interspecies inhibition of Porphyromonas gingivalis by yogurt-derived Lactobacillus delbrueckii require active pyruvate oxidase. Appl Environ Microbiol. Epub ahead of print. Abstract

Phelan JP, Kern A, Ramsey ME, Lundt ME, Sharma B, Lin T, Gao L, Norris SJ, Hyde JA, Skare JT, Hu LT. 2019. Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector. PLoS Pathog. 15: e1007644. Abstract

Wang Y, Esquivel R, Flingai S, Schiller ZA, Kern A, Agarwal S, Chu J, Patel A, Sullivan K, Wise MC, Broderick KE, Hu L, Weiner DB, Klempner MS. 2018. Anti-OspA DNA-encoded monoclonal antibody prevents transmission of spirochetes in tick challenge providing sterilizing immunity in mice. J Infect Dis. 219: 1146-1150. Abstract

Wu X, Sharma B, Niles S, O'Connor K, Schilling R, Matluck N, D'Onofrio A, Hu LT, Lewis K. 2018. Identifying vancomycin as an effective antibiotic for killing Borrelia burgdorferi. Antimicrob Agents Chemother. 62(11). pii: e01201-18. Abstract

Petnicki-Ocwieja T, Hu LT. 2018. Magnetic isolation of phagosomes containing Toll-like receptor ligands. Methods Mol Biol. 1690: 329-336. Abstract

Killpack TL, Ballesteros M, Bunnell SC, Bedugnis A, Kobzik L, Hu LT, Petnicki-Ocwieja T. 2017. Phagocytic receptors activate Syk and Src signaling during Borrelia burgdorferi phagocytosis. Infect Immun. 85(10). pii: e00004-17. Abstract

Klein BA, Cornacchione LP, Collins M, Malamy MH, Duncan MJ, Hu LT. 2017. Using Tn-seq to identify pigmentation related genes of Porphyromonas gingivalis: Characterization of the role of a putative glycosyltransferase. J Bacteriol. 199: e00832-16.  Abstract

Ramsey ME, Hyde JA, Medina-Perez DN, Lin T, Gao L, Lundt ME, Li X, Norris SJ, Skare JT, Hu LT. 2017. A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species. PLoS Pathog. 13: e1006225.  Abstract

Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS. 2016. Lyme borreliosis. Nat Rev Dis Primers 2:16090. Abstract

Hu, L. 2016. Lyme disease. Ann Intern Med. 165: 677.  Abstract

Kern A, Zhou CW, Jia F, Xu Q, Hu LT. 2016. Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release. Vaccine 34: 45078-4513. Abstract

Wang Y, Kern A, Boatright NK, Schiller ZA, Sadowski A, Ejemel M, Souders CA, Reimann KA, Hu L, Thomas WD Jr, Klempner MS. 2016. Pre-exposure prophylaxis with OspA-specific human monoclonal antibodies protects mice against tick transmission of Lyme Disease spirochetes. J Infect Dis. 214: 205-211.  Abstract

Troy EB, Lin T, Gao L, Lazinski DW, Lundt M, Camilli A, Norris SJ, Hu LT. 2016. Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi. Mol Microbiol. 101: 1003-1023.  Abstract

Sanchez E, Vannier E, Wormser GP, Hu LT. 2016. Diagnosis, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: A review. JAMA. 315: 1767-1777.  Abstract

Klein BA, Chen T, Scott JC, Koenigsberg AL, Duncan MJ, Hu LT. 2015. Identification and characterization of a minisatellite contained within a novel miniature inverted-repeat transposable element (MITE) of Porphyromonas gingivalis Mob DNA 6:18.  Abstract

Petnicki-Ocwieja T, Kern A, Killpack TL, Bunnell SC, Hu LT. 2015. Adaptor protein-3-mediated trafficking of TLR2 ligands controls specificity of inflammatory responses but not adaptor complex assembly. J Immunol. 195: 4331-4340. Abstract

Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. 2015. Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells. Antimicrob Agents Chemother. 59: 4616-4624. Abstract

Klein BA, Duncan MJ, Hu LT. 2015. Defining essential genes and identifying virulence factors of Porphyromonas gingivalis by massively parallel sequencing of transposon libraries (Tn-seq). Methods Mol Biol. 1279:25-43. Abstract

Telford SR 3rd, Hu LT, Marques A. 2014. Is there a place for xenodiagnosis in the clinic? Expert Rev Anti Infect Ther. 12: 1307-1310. Abstract

Scott JC, Klein BA, Duran-Pinedo A, Hu L, Duncan MJ. 2013. A two-component system regulates hemin acquisition in Porphyromonas gingivalis. PLoS One 8: e73351. Abstract

Troy EB, Lin T, Gao L, Lazinski DW, Camilli A, Norris SJ, Hu L. 2013. Understanding barriers to Borrelia burgdorferi dissemination during infection using massively parallel sequencing. Infect Immun. 81: 2347-2357. Abstract

Petnicki-Ocwieja T, Chung E, Acosta DI, Ramos LT, Shin OS, Ghosh S, Kobzik L, Li X, Hu LT. 2013. TRIF mediates TLR2 dependent inflammatory responses to Borrelia burgdorferi. Infect Immun. 81: 402-410. Abstract

Klein BA, Tenorio EL, Lazinski DW, Camilli A, Duncan MJ, Hu LT. 2012. Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis. BMC Genomics 13: 578. Abstract

Hu LT. 2012. In the clinic. Lyme disease. Ann Intern Med. 157: ITC2-2 - ITC2-16. Abstract

Bensaci M, Bhattacharya D, Clark R, Hu LT. 2012. Oral vaccination with vaccinia virus expressing the tick antigen subolesin inhibits tick feeding and transmission of Borrelia burgdorferi. Vaccine 30: 6040-6046. Abstract