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Graduate School of Biomedical Sciences

Recent Publications from the Haydon Lab

Armbruster M, Naskar S, Garcia JP, Sommer M, Kim E, Adam Y, Haydon PG, Boyden ES, Cohen AE, Dulla CG. 2022. Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes. Nat Neurosci. Apr 28. doi: 10.1038/s41593-022-01049-x. Abstract

Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. 2021. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 24: 312-325. Abstract

Nagai J, Yu X, Papouin T, Cheong E, Freeman MR, Monk KR, Hastings MH, Haydon PG, Rowitch D, Shaham S, Khakh BS. 2020. Behaviorally consequential astrocytic regulation of neural circuits. Neuron. 109: 576-596. Abstract

Turovsky EA, Braga A, Yu Y, Esteras N, Korsak A, Theparambil SM, Hadjihambi A, Hosford PS, Teschemacher AG, Marina N, Lythgoe MF, Haydon PG, Gourine AV. 2020. Mechanosensory signalling in astrocytes. J Neurosci. 40: 9364-9371. Abstract

Lombardo S, Chiacchiaretta M, Tarr A, Kim W, Cao T, Sigal G, Rosahl TW, Xia W, Haydon PG, Kennedy ME, Tesco G. 2019. BACE1 partial deletion induces synaptic plasticity deficit in adult mice. Sci Rep. 9(1):19877. doi: 10.1038/s41598-019-56329-7. Abstract

Chetty A, Sharda A, Warburton R, Weinberg EO, Dong J, Fang M, Sahagian GG, Chen T, Xue C, Castellot JJ, Haydon PG, Nielsen HC. 2018. A purinergic P2Y6 receptor agonist prodrug modulates airway inflammation, remodeling, and hyperreactivity in a mouse model of asthma. J Asthma Allergy. 11: 159:171. Abstract

Papouin T, Haydon PG. 2018. D-serine measurements in brain slices or other tissue explants. Bio Protoc. 8 pii: e2698. Abstract

Papouin T, Haydon PG. 2018. Obtaining acute brain slices.Bio Protoc. 8 pii: e2699. Abstract

Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, Haydon PG, Tesco G. 2018. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 13: 6. Abstract

Clasadonte J, Scemes E, Wang Z, Boison D, Haydon PG. 2017. Connexin 43-mediated astroglial metabolic networks contribute to the regulation of the sleep-wake cycle. Neuron 95: 1365-1380. Abstract

Papouin T, Dunphy JM, Tolman M, Dineley KT, Haydon PG. 2017. Septal cholinergic neuromodulation tunes the astrocyte-dependent gating of hippocampal NMDA receptors to wakefulness. Neuron Epub ahead of print. Abstract

Haydon, PG. 2017. Astrocytes and the modulation of sleep. Curr Opin Neurobiol. 44:28-33. Abstract

Foley J, Blutstein T, Lee S, Erneux C, Halassa MM, Haydon P. 2017. Astrocytic IP3/Ca2+ signaling modulates theta rhythm and REM sleep. Front Neural Circuits 11:3.  Abstract

Papouin T, Dunphy J, Tolman M, Foley JC, Haydon PG. 2017. Astrocytic control of synaptic function. Philos Trans R Soc Lond B Biol Sci. 372 (1715). Abstract

Keck T, Toyoizumi T, Chen L, Doiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hübener M, Lee HK, Lisman JE, Rose T, Sengpiel F, Stellwagen D, Stryker MP, Turrigiano GG, van Rossum MC. 2017. Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philos Trans R Soc Lond B Biol Sci. 372 (1715). Abstract

Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G. 2016. Genetic deletion of the clathrin adaptor GGA3 reduces anxiety and alters GABAergic transmission. PLoS One 11: e0155799. Abstract

Clasadonte J, Morel L, Barrios-Camacho CM, Chiang MS, Zhang J, Iyer L, Haydon PG, Yang Y. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiol Dis. Epub ahead of print. Abstract

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. 2015. Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment. PLoS Pathog. 11: e1005126.  Abstract

Scofield MD, Boger HA, Smith RJ, Li H, Haydon PG, Kalivas PW. 2015. Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking. Biol Psychiatry 78: 441-451. Abstract

Haydon PG, Nedergaard M. 2014. How do astrocytes participate in neural plasticity? Cold Spring Harb Perspect Biol. 7: a020438. Abstract

Clasadonte J, Haydon PG. 2014. Connexin 30 controls the extension of astrocytic processes into the synaptic cleft through an unconventional non-channel function. Neurosci Bull. 30: 1045-1048. Abstract

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. New molecular insights into cognitive and autistic-like disabilities. Mol Psychiatry 19: 1053. Abstract

Terunuma M, Haydon PG, Pangalos MN, Moss SJ. 2014. Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Neuropharmacology 88: 74-81. Abstract

Hines DJ, Haydon PG. 2014. Astrocytic adenosine: from synapses to psychiatric disorders. Philos Trans R Soc Lond B Biol Sci. 369. Abstract

Huyghe D, Nakamura Y, Terunuma M, Faideau M, Haydon P, Pangalos NM, Moss SJ. 2014. Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by G-aminobutyric type B receptors. J Biol Chem. 289: 28808-28815. Abstract

Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH. 2014. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. Mol Psychiatry 19: 133-142. Abstract

Araque A, Carmignoto G, Haydon PG, Oliet SH, Robitaille R, Volterra A. 2014. Gliotransmitters travel in time and space. Neuron 81: 728-739. Abstract

Kawamata H, Ng SK, Diaz N, Burstein S, Morel L, Osgood A, Sider B, Higashimori H, Haydon PG, Manfredi G, Yang Y. 2014. Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J Neurosci. 34: 2331-2348. Abstract

Clasadonte J, McIver SR, Schmitt LI, Halassa MM, Haydon PG. 2014. Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci. 34: 1879-1891. Abstract

Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN, Moss SJ. 2014. Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. J Neurosci. 34: 804-816. Abstract

Lalo U, Palygin O, Rasooli-Nejad S, Andrew J, Haydon PG, Pankratov Y. 2014. Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. PLoS Biol. 12: e1001747. Abstract

Clasadonte J, Dong J, Hines DJ, Haydon PG 2013. Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy. Proc Natl Acad Sci USA 110: 17540-17545. Abstract

Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ. 2013. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABAA-receptor γ2 subunit. J Neurosci. 39: 15567-15577. Abstract

Hines RM, Hines DJ, Houston CM, Mukherjee J, Haydon PG, Tretter V, Smart TG, Moss SJ. 2013. Disrupting the clustering of GABAA receptor α2 subunits in the frontal cortex leads to reduced γ-power and cognitive deficits. Proc Natl Acad Sci USA 100: 16628-16633. Abstract

Hines DJ, Haydon PG. 2013. Inhibition of a SNARE-sensitive pathway in astrocytes attenuates damage following stroke. J Neurosci. 33:4234-4240. Abstract

Nadjar A, Blutstein T, Aubert A, Laye S, Haydon PG. 2013. Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response. Glia 61: 724-731. Abstract

Hines DJ, Schmitt LI, Hines RM, Moss SJ, Haydon PG. 2013. Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl Psychiatry 15: e212. Abstract

Choo AM, Miller WJ, Chen YC, Nibley P, Patel TP, Goletiani C, Morrison B 3rd, Kutzing MK, Firestein BL, Sul JY, Haydon PG, Meaney DF. 2013. Antagonism of purinergic signalling improves recovery from traumatic brain injury. Brain 136(Pt1): 65-80. Abstract

Blutstein T, Haydon PG. 2013. The Importance of astrocyte-derived purines in the modulation of sleep. Glia 61: 129-139. Abstract

Turner JR, Ecke LE, Briand LA, Haydon PG, Blendy JA. 2013. Cocaine-related behaviors in mice with deficient gliotransmission. Psychopharmacology (Berlin) 226: 167-176. Abstract