I maintain an active laboratory but no longer accept students for dissertation research. I am willing to serve as a co-mentor for thesis students and I participate in teaching and other graduate program activities.
My laboratory studies genes important for embryonic development of mice, and the connections between mutations in these genes and congenital and acquired human disease. Our analyses focus on the Notch pathway, an evolutionarily conserved intercellular signaling system, and on genes of the Snail superfamily, which encode transcriptional repressor proteins. We have created and analyzed numerous genetically engineered mouse models to understand the essential functions of individual components of these pathways, and have generated models for inherited human disease syndromes such as Alagille syndrome. We are particularly interested in the role these pathways play during cardiovascular development, physiology and disease.