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Graduate School of Biomedical Sciences

David J Greenblatt

Louis Lasagna, MD, Professor, Professor of Immunology
David J Greenblatt

David J Greenblatt

Louis Lasagna, MD, Professor, Professor of Immunology

Office phone: 617-636-6997
Lab phone: 617-636-6949
Campus: Boston
Office: M&V 606
M&V 605
BA, Mathematics, Amherst College
MD, Harvard Medical School
Postdoctoral Training, Harvard Medical School
Research synopsis: 

Our research work has a focus on the following areas: molecular and clinical pharmacokinetics/pharmacodynamics; genetic and environmental factors regulating drug metabolism by Cytochromes P450 and glucuronosyl transferases, and energy-dependent transport by P-glycoprotein and other transporters; mechanisms, consequences, and in vitro prediction of metabolic drug-drug interactions attributable to enzyme inhibition and induction; effect of age, gender, body habitus, and dietary composition on drug disposition and response; drug interactions involving nutrients and natural substances; molecular and clinical determinants of ligand binding and pharmacodynamic response to centrally-acting drugs. Principal techniques used in the laboratory include: high-pressure liquid chromatography (HPLC) and HPLC with mass spectroscopy for quantitation of drugs and metabolites; in vitro drug metabolism models based on human liver microsomal preparations and recombinant human enzymes; genetic identification and quantitation of single nucleotide polymorphisms altering drug metabolism phenotype; nonlinear regression procedures for pharmacokinetic/pharmacodynamics simulation and modeling.

Lab members: