Our research centers on understanding the molecular, cellular, and systemic basis of obesity and its complications. We have focused a significant amount of our research on the proteins that regulate the cellular trafficking, storage and metabolism of fatty acids and lipid metabolism. An important goal of our laboratory is to delineate mechanisms that will provide mechanistic insights into pathways that will ameliorate obesity and/or its metabolic and inflammatory complications. In our studies we use cells, tissues, mouse knockout models, and human tissues and in certain situations clinical studies. Our initial studies focused on white and brown adipocyte metabolism and its systemic consequences, our work has now branched has branched into studies liver, intestine, and skeletal muscle metabolism, the microbiome, and regulation of brain metabolism relevant to our studies on metabolic pathways. As Associate Director of the NIDDK funded Boston Nutrition Obesity Research Center (BNORC), we attend the biweekly BNORC Adipose and Metabolic Study Group Seminars. Additionally, as Co-Director of the Adipocyte Biology and Nutrient Metabolism Core at BNORC, our laboratory has the ability to characterize mouse metabolism and body composition, using a MRI to rapidly and noninvasively measure body fat and lean mass, metabolic chambers to measure energy expenditure, nutrient partitioning, and rates of spontaneous physical, and the hyperinsulinemic, euglycemic clamp technique to measure liver, adipose, and skeletal muscle insulin sensitivity in mouse models.