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Graduate School of Biomedical Sciences

Recent Publications from the Georgakoudi Lab

Pouli D, Thieu HT, Genega EM, Baecher-Lind L, House M, Bond B, Roncari DM, Evans ML, Rius-Diaz F, Munger K, Georgakoudi I. 2020. Label-free, high-resolution optical metabolic imaging of human cervical precancers reveals potential for intraepithelial neoplasia diagnosis. Cell Rep Med. pii: 100017. doi: 10.1016/j.xcrm.2020.100017. Abstract

Liaudanskaya V, Chung JY, Mizzoni C, Rouleau N, Berk AN, Wu L, Turner JA, Georgakoudi I, Whalen MJ, Nieland TJF, Kaplan DL. 2020. Modeling controlled cortical impact injury in 3D brain-like tissue cultures. Adv Health Mater. 13:e2000122. doi: 10.1002/adhm.202000122. Abstract

Zhang Y, Baloglu FK, Ziemer LEH, Liu Z, Lyu B, Arendt LM, Georgakoudi I. 2020 Factors associated with obesity alter matrix remodeling in breast cancer tissues. J Biomed Opt. 25: 1-14. Abstract

Smokelin I, Mizzoni C, Erndt-Marino J, Kaplan D, Georgakoudi I. 2020. Optical changes in THP-1 macrophage metabolism in response to pro- and anti-inflammatory stimuli reported by label-free two-photon imaging. J Biomed Opt. 25: 1-14. Abstract

Sood D, Tang-Schomer M, Pouli D, Mizzoni C, Raia N, Tai A, Arkun K, Wu J, Black LD 3rd, Scheffler B, Georgakoudi I, Steindler DA, Kaplan DL. 2019. 3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors. Nat Commun. 10(1):4529. doi: 10.1038/s41467-019-12420-1. Abstract

Huang M, Liu Z, Baugh L, DeFuria J, Maione A, Smith A, Kashpur O, Black III LD, Georgakoudi I, Whitfield ML, Garlick J. 2018. Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues. Lab Invest. Epub ahead of print. Abstract

Siran W, Ghezzi CE, Cairns DM, Pollard RE, Chen Y, Gomes R, McKay TB, Pouli D, Jamali A, Georgakoudi I, Funderburgh JL, Kenyon K, Hamrah P, Kaplan DL. 2018. Human corneal tissue model for nociceptive assessments. Adv Health Mater. Epub ahead of print. Abstract

Liu Z, Speroni L, Quinn KP, Alonzo C, Pouli D, Zhang Y, Stuntz E, Sonnenschein C, Soto AM, Georgakoudi I. 2018. 3D organizational mapping of collagen fibers elucidates matrix remodeling in a hormone-sensitive 3D breast tissue model. Biomaterials. 179: 96-108. Abstract

Hui Mingalone CK, Liu Z, Hollander JM, Garvey KD, Gibson AL, Banks RE, Zhang M, McAlindon TE, Nielsen HC, Georgakoudi I, Zeng L. 2018. Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis. Lab Invest. 98: 656-669. Abstract

Liu Z, Pouli D, Alonzo CA, Varone A, Karaliota S, Quinn KP, Münger K, Karalis KP, Georgakoudi I. 2018. Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast. Sci Adv. 4: eaap9302. Abstract

Freytsis M, Baugh L, Liu Z, Georgakoudi I, Hinds PW, Black LD, Huggins GS. 2018. Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation. PLoS One 13: e0190623. Abstract

Watkins MT, Georgakoudi I, Austen WG Jr, Bei M, Bouma BE, Mihm MC Jr, Yarmush ML. 2018. Skin regeneration with all accessory organs following ablation with irreversible electroporation. J Tissue Eng Regen Med. 12: 98-113. Abstract

Baugh LM, Liu Z, Quinn KP, Osseiran S, Evans CL, Huggins GS, Hinds PW, Black LD, Georgakoudi I. 2017. Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease. Nat Biomed Eng. 1: 914-924. Abstract

Pouli D, Tozzi L, Alonzo CA, Liu Z, Kaplan DL, Balduini A, Georgakoudi I. 2017. Label free monitoring of megakaryocytic development and proplatelet formation in vitro. Biomed Opt Express. 8: 4742-4755. Abstract

Uchimura T, Hollander JM, Nakamura DS, Liu Z, Rosen CJ, Georgakoudi I, Zeng L. 2017. An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth. Development 144: 3533-3546. Abstract

Feeney MJ, Hu X, Srinivasan R, Van N, Hunter M, Georgakoudi I, Thomas SW 3rd. 2017. UV and NIR-responsive layer-by-layer films containing 6-bromo-7-hydroxycoumarin photolabile groups. Langmuir 33: 10877-10885. Abstract

Abbott RD, Borowsky FE, Alonzo CA, Zieba A, Georgakoudi I, Kaplan DL. 2017. Endogenous two-photon excited fluorescence imaging characterizes neuron and astrocyte metabolic responses to manganese toxicity. Sci Rep. 7: 1041. Abstract

Wang X, Li Y, Li Q, Neufeld CI, Pouli D, Sun S, Yang L, Deng P, Wang M, Georgakoudi I, Tang S, Xu Q. 2017. Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles. J Control Release. 263: 39-45. Abstract

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I. 2017. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials 116: 34-47. Abstract

Quinn KP, Sullivan KE, Liu Z, Ballard Z, Siokatas C, Georgakoudi I, Black LD. 2016. Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction. Sci Rep 6: 35823. Abstract

Alonzo CA, Karaliota S, Pouli D, Liu Z, Karalis KP, Georgakoudi I. 2016. Two-photon excited fluorescence of intrinsic fluorophores enables label-free assessment of adipose tissue function.Sci Rep. 6: 31912. Abstract

Lyons J, Polmear M, Mineva ND, Romagnoli M, Sonenshein GE, Georgakoudi I. 2016. Endogenous light scattering as an optical signature of circulating tumor cell clusters. Biomed Opt Express. 7: 1042-1050. Abstract

Yildirim M, Quinn KP, Kobler JB, Zeitels SM, Georgakoudi I, Ben-Yakar A. 2016. Quantitative differentiation of normal and scarred tissues using second-harmonic generation microscopy. Scanning. 38: 684-693. Abstract

Wang M, Zuris JA, Meng F, Rees H, Sun S, Deng P, Han Y, Gao X, Pouli D, Wu Q, Georgakoudi I, Liu DR, Xu Q. 2016. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proc Natl Acad Sci USA 113: 2868-2873. Abstract

Quinn KP, Leal EC, Tellechea A, Kafanas A, Auster ME, Veves A, Georgakoudi I. 2016. Diabetic wounds exhibit distinct microstructural and metabolic heterogeneity through label-free multiphoton microscopy. J Invest Dermatol. 136: 342-344. Abstract

Sood D, Chwalek K, Stuntz E, Pouli D, Du C, Tang-Schomer M, Georgakoudi I, Black LD 3rd, Kaplan DL. 2016. Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue. ACS Biomater Sci Eng.2: 131-140.  Abstract

Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL. 2016. Non-invasive assessments of adipose tissue metabolism in vitro. Ann Biomed Eng. 44: 725-732. Abstract